Results 21 to 30 of about 121,463 (292)

An Updated Model of the Divisome: Regulation of the Septal Peptidoglycan Synthesis Machinery by the Divisome

open access: yesInternational Journal of Molecular Sciences, 2022
The synthesis of a peptidoglycan septum is a fundamental part of bacterial fission and is driven by a multiprotein dynamic complex called the divisome.
Mohamed Attaibi, T. den Blaauwen
semanticscholar   +1 more source

Staphylococcus aureus sacculus mediates activities of M23 hydrolases

open access: yesNature Communications, 2023
Peptidoglycan, a gigadalton polymer, functions as the scaffold for bacterial cell walls and provides cell integrity. Peptidoglycan is remodelled by a large and diverse group of peptidoglycan hydrolases, which control bacterial cell growth and division ...
Alicja Razew   +6 more
doaj   +1 more source

Amidation of glutamate residues in mycobacterial peptidoglycan is essential for cell wall cross-linking

open access: yesFrontiers in Cellular and Infection Microbiology, 2023
IntroductionMycobacteria assemble a complex cell wall with cross-linked peptidoglycan (PG) which plays an essential role in maintenance of cell wall integrity and tolerance to osmotic pressure.
Moagi T. Shaku   +6 more
doaj   +1 more source

A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum

open access: yesmBio, 2019
Chlamydiales species are obligate intracellular bacteria lacking a classical peptidoglycan sacculus but relying on peptidoglycan synthesis for cytokinesis.
Nicolas Jacquier   +5 more
doaj   +1 more source

Peptidoglycan derived from MLGA up-regulates the expression of chicken -defensin 9 without triggering an inflammatory response

open access: yesInnate Immunity, 2020
Defensins are critical components of the innate immune system and play an important role in the integration of innate and adaptive immune responses.
Juan Huang   +6 more
doaj   +1 more source

Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection*

open access: yesJournal of Biological Chemistry, 2003
Nod2 activates the NF-κB pathway following intracellular stimulation by bacterial products. Recently, mutations inNod2 have been shown to be associated with Crohn's disease, suggesting a role for bacteria-host interactions in the etiology of this ...
S. Girardin   +7 more
semanticscholar   +1 more source

Atomic Force Microscopy of Side Wall and Septa Peptidoglycan From Bacillus subtilis Reveals an Architectural Remodeling During Growth

open access: yesFrontiers in Microbiology, 2018
Peptidoglycan is the fundamental structural constituent of the bacterial cell wall. Despite many years of research, the architecture of peptidoglycan is still largely elusive.
Kang Li   +12 more
doaj   +1 more source

A peptidoglycan storm caused by β-lactam antibiotic’s action on host microbiota drives Candida albicans infection

open access: yesNature Communications, 2021
The commensal fungus Candida albicans often causes life-threatening infections in patients who are immunocompromised with high mortality. A prominent but poorly understood risk factor for the C.
Chew Teng Tan   +3 more
semanticscholar   +1 more source

Digestion of Peptidoglycan and Analysis of Soluble Fragments

open access: yesBio-Protocol, 2017
Peptidoglycan (murein) is a vital component of the cell wall of nearly all bacteria, composed of sugars linked by short peptides. This protocol describes the purification of macromolecular peptidoglycan from cultured bacteria and the analysis of enzyme ...
Ryan Schaub, Joseph Dillard
doaj   +1 more source

Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex

open access: yesNature Microbiology, 2020
The shape, elongation, division and sporulation (SEDS) proteins are a highly conserved family of transmembrane glycosyltransferases that work in concert with class B penicillin-binding proteins (bPBPs) to build the bacterial peptidoglycan cell wall 1 – 6
M. Sjodt   +13 more
semanticscholar   +1 more source

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