Results 31 to 40 of about 121,463 (292)

Resistance to mucosal lysozyme compensates for the fitness deficit of peptidoglycan modifications by Streptococcus pneumoniae. [PDF]

PLoS Pathogens, 2008
The abundance of lysozyme on mucosal surfaces suggests that successful colonizers must be able to evade its antimicrobial effects. Lysozyme has a muramidase activity that hydrolyzes bacterial peptidoglycan and a non-muramidase activity attributable to ...
Kimberly M Davis, Henry T Akinbi, Alistair J Standish, Jeffrey N Weiser   +3 more
doaj   +1 more source

DpaA Detaches Braun’s Lipoprotein from Peptidoglycan

bioRxiv, 2021
Gram-negative bacteria have a complex cell envelope with two membranes and a periplasm containing the peptidoglycan layer. The outer membrane is firmly connected to the peptidoglycan by highly abundant proteins.
Matthias Winkle, Víctor M. Hernández-Rocamora, Karthik Pullela, E. C. Goodall, A. Martorana, J. Gray, I. Henderson, A. Polissi, W. Vollmer   +8 more
semanticscholar   +1 more source

Characterization of Pseudomonas aeruginosa l,d-Transpeptidases and Evaluation of Their Role in Peptidoglycan Adaptation to Biofilm Growth

Microbiology Spectrum, 2023
Peptidoglycan is an essential component of the bacterial cell envelope that sustains the turgor pressure of the cytoplasm, determines cell shape, and acts as a scaffold for the anchoring of envelope polymers such as lipoproteins.
Inès Hugonneau-Beaufet, Jean-Philippe Barnier, Stanislas Thiriet-Rupert, Sylvie Létoffé, Jean-Luc Mainardi, Jean-Marc Ghigo, Christophe Beloin, Michel Arthur   +7 more
doaj   +1 more source

Removal of peptidoglycan and inhibition of active cellular processes leads to daptomycin tolerance in Enterococcus faecalis.

PLoS ONE, 2021
Daptomycin is a cyclic lipopeptide antibiotic used in the clinic for treatment of severe enterococcal infections. Recent reports indicate that daptomycin targets active cellular processes, specifically, peptidoglycan biosynthesis. Within, we examined the
Rachel D Johnston, Brittni M Woodall, Johnathan Harrison, Shawn R Campagna, Elizabeth M Fozo   +4 more
doaj   +1 more source

Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2*

Journal of Biological Chemistry, 1999
The life-threatening complications of sepsis in humans are elicited by infection with Gram-negative as well as Gram-positive bacteria. Recently, lipopolysaccharide (LPS), a major biologically active agent of Gram-negative bacteria, was shown to mediate ...
R. Schwandner, R. Dziarski, H. Wesche, M. Rothe, C. Kirschning   +4 more
semanticscholar   +1 more source

Bacterial Cell Enlargement Requires Control of Cell Wall Stiffness Mediated by Peptidoglycan Hydrolases

mBio, 2015
Most bacterial cells are enclosed in a single macromolecule of the cell wall polymer, peptidoglycan, which is required for shape determination and maintenance of viability, while peptidoglycan biosynthesis is an important antibiotic target.
Richard Wheeler, Robert D. Turner, Richard G. Bailey, Bartłomiej Salamaga, Stéphane Mesnage, Sharifah A. S. Mohamad, Emma J. Hayhurst, Malcolm Horsburgh, Jamie K. Hobbs, Simon J. Foster   +9 more
doaj   +1 more source

FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein

Nature Microbiology, 2018
The peptidoglycan cell wall is essential for the survival and morphogenesis of bacteria1. For decades, it was thought that only class A penicillin-binding proteins (PBPs) and related enzymes effected peptidoglycan synthesis.
A. Taguchi, Michael A. Welsh, L. S. Marmont, Wonsik Lee, M. Sjodt, A. Kruse, D. Kahne, T. Bernhardt, S. Walker   +8 more
semanticscholar   +1 more source

Membrane-partitioned cell wall synthesis in mycobacteria

eLife, 2021
Many antibiotics target the assembly of cell wall peptidoglycan, an essential, heteropolymeric mesh that encases most bacteria. In rod-shaped bacteria, cell wall elongation is spatially precise yet relies on limited pools of lipid-linked precursors that ...
Alam García-Heredia, Takehiro Kado, Caralyn E Sein, Julia Puffal, Sarah H Osman, Julius Judd, Todd A Gray, Yasu S Morita, M Sloan Siegrist   +8 more
doaj   +1 more source

Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi‐enzyme complexes in Escherichia coli

EMBO Journal, 2020
The peptidoglycan (PG) sacculus provides bacteria with the mechanical strength to maintain cell shape and resist osmotic stress. Enlargement of the mesh‐like sacculus requires the combined activity of peptidoglycan synthases and hydrolases.
M. Banzhaf, Hamish C L Yau, Jolanda Verheul, Adam Lodge, G. Kritikos, A. Mateus, Baptiste Cordier, A. Hov, F. Stein, Morgane Wartel, M. Pazos, A. Solovyova, E. Breukink, S. van Teeffelen, M. Savitski, T. den Blaauwen, Athanasios Typas, W. Vollmer   +17 more
semanticscholar   +1 more source

Peptidoglycan Muropeptides: Release, Perception, and Functions as Signaling Molecules

Frontiers in Microbiology, 2019
Peptidoglycan (PG) is an essential molecule for the survival of bacteria, and thus, its biosynthesis and remodeling have always been in the spotlight when it comes to the development of antibiotics.
Oihane Irazoki, Sara B. Hernández, Felipe Cava   +2 more
semanticscholar   +1 more source