Peptidoglycan and Nod Receptor [PDF]
Bacterial cells are encompassed by a macromolecular network of peptidoglycan, the major component of bacterial cell walls that provides the cell wall strength and determines bacterial morphology. Eukaryotic organisms sense the presence of bacteria by detecting peptidoglycan fragments shed by the bacterium or released through hydrolytic attack by host ...
Catherine Werts+7 more
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A peptidoglycan hydrolase motif within the mycobacteriophage TM4 tape measure protein promotes efficient infection of stationary phase cells [PDF]
The predominant morphotype of mycobacteriophage virions has a DNA-containing capsid attached to a long flexible non-contractile tail, features characteristic of the Siphoviridae.
Hatfull, GF, Piuri, M
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Covalent attachment of proteins to peptidoglycan [PDF]
Bacterial surface proteins are key players in host-symbiont or host-pathogen interactions. How these proteins are targeted and displayed at the cell surface are challenging issues of both fundamental and clinical relevance. While surface proteins of Gram-negative bacteria are assembled in the outer membrane, Gram-positive bacteria predominantly utilize
Michel Arthur+9 more
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The Effect of NAG–thiazoline on Morphology and Surface Hydrophobicity of Escherichia Coli [PDF]
The β-hexosaminidase inhibitor and structural analog of the putative oxazolium reaction intermediate of lytic transglycosylases, N-acetylglucosamine thiazoline (NAG–thiazoline), was synthesized in 46% overall yield and tested as an inhibitor of ...
Blackburn, Neil T.+2 more
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Peptidoglycan Composition in Neisseria [PDF]
The composition of Neisseria peptidoglycan has been of scientific interest for over four decades. Initial investigations focused on discovering the mechanisms causing rising rates of antibiotic resistance in N. gonorrhoeae by determining differences in peptidoglycan composition in penicillin susceptible and resistant strains.
Ryan E. Schaub, Joseph P. Dillard
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Dual strategies for peptidoglycan discrimination by peptidoglycan recognition proteins (PGRPs) [PDF]
The innate immune system constitutes the first line of defense against microorganisms in both vertebrates and invertebrates. Although much progress has been made toward identifying key receptors and understanding their role in host defense, far less is known about how these receptors recognize microbial ligands. Such studies have been severely hampered
Swaminathan, Chittoor P.+8 more
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Imbalance of peptidoglycan biosynthesis alters the cell surface charge of Listeria monocytogenes
The bacterial cell wall is composed of a thick layer of peptidoglycan and cell wall polymers, which are either embedded in the membrane or linked to the peptidoglycan backbone and referred to as lipoteichoic acid (LTA) and wall teichoic acid (WTA ...
Lisa Maria Schulz+4 more
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The molecular architecture of engulfment during Bacillus subtilis sporulation. [PDF]
The study of bacterial cell biology is limited by difficulties in visualizing cellular structures at high spatial resolution within their native milieu.
Khanna, Kanika+7 more
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The Integrity of the Cell Wall and Its Remodeling during Heterocyst Differentiation Are Regulated by Phylogenetically Conserved Small RNA Yfr1 in Nostoc sp. Strain PCC 7120 [PDF]
Yfr1 is a strictly conserved small RNA in cyanobacteria. A bioinformatic prediction to identify possible interactions of Yfr1 with mRNAs was carried out by using the sequences of Yfr1 from several heterocyst-forming strains, including Nostoc sp.
Brenes Álvarez, Manuel+2 more
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Daptomycin is a cyclic lipopeptide antibiotic used in the clinic for treatment of severe enterococcal infections. Recent reports indicate that daptomycin targets active cellular processes, specifically, peptidoglycan biosynthesis. Within, we examined the
Rachel D Johnston+4 more
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