Results 51 to 60 of about 147,833 (381)
Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome [PDF]
, 2008 Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with `cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent ...
Alessandro Plebani +19 more
core +1 more source
Microbiology Spectrum, 2023 Peptidoglycan is an essential component of the bacterial cell envelope that sustains the turgor pressure of the cytoplasm, determines cell shape, and acts as a scaffold for the anchoring of envelope polymers such as lipoproteins.
Inès Hugonneau-Beaufet +7 more
doaj +1 more source
Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers. [PDF]
, 2017 Occult bacterial infections represent a worldwide health problem. Differentiating active bacterial infection from sterile inflammation can be difficult using current imaging tools. Present clinically viable methodologies either detect morphologic changes
Blecha, Joseph E +10 more
core +1 more source
Nature Microbiology, 2018 The peptidoglycan cell wall is essential for the survival and morphogenesis of bacteria1. For decades, it was thought that only class A penicillin-binding proteins (PBPs) and related enzymes effected peptidoglycan synthesis.
A. Taguchi +8 more
semanticscholar +1 more source
Genetics of Peptidoglycan Biosynthesis
Microbiology Spectrum, 2014 ABSTRACT The complex cell envelope is a hallmark of mycobacteria and is anchored by the peptidoglycan layer, which is similar to that of Escherichia coli and a number of other bacteria but with modifications to the monomeric units and other structural complexities that are likely related to a role for the ...
Sebabrata Mahapatra +2 more
openaire +3 more sources
Activities and regulation of peptidoglycan synthases [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2015 Peptidoglycan (PG) is an essential component in the cell wall of nearly all bacteria, forming a continuous, mesh-like structure, called the sacculus, around the cytoplasmic membrane to protect the cell from bursting by its turgor. Although PG synthases, the penicillin-binding proteins (PBPs), have been studied for 70 years, useful
Egan AJF +4 more
openaire +5 more sources
In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA). [PDF]
PLoS Pathogens, 2017 The O-acetylation of the essential cell wall polymer peptidoglycan occurs in most Gram-positive bacterial pathogens, including species of Staphylococcus, Streptococcus and Enterococcus. This modification to peptidoglycan protects these pathogens from the
David Sychantha +9 more
doaj +1 more source
How innate immunity proteins kill bacteria and why they are not prone to resistance [PDF]
, 2017 Recent advances on antibacterial activity of peptidoglycan recognition proteins (PGRPs) offer some insight into how innate immunity has retained its antimicrobial effectiveness for millions of years with no frequent emergence of resistant strains. First,
Dziarski, Roman, Gupta, Dipika
core +1 more source
Peptidoglycan Muropeptides: Release, Perception, and Functions as Signaling Molecules
Frontiers in Microbiology, 2019 Peptidoglycan (PG) is an essential molecule for the survival of bacteria, and thus, its biosynthesis and remodeling have always been in the spotlight when it comes to the development of antibiotics.
Oihane Irazoki +2 more
semanticscholar +1 more source
EMBO Journal, 2020 The peptidoglycan (PG) sacculus provides bacteria with the mechanical strength to maintain cell shape and resist osmotic stress. Enlargement of the mesh‐like sacculus requires the combined activity of peptidoglycan synthases and hydrolases.
M. Banzhaf +17 more
semanticscholar +1 more source