Results 1 to 10 of about 87,487 (247)

Prediction of peptidoglycan hydrolases- a new class of antibacterial proteins. [PDF]

BMC Genomics, 2016
The efficacy of antibiotics against bacterial infections is decreasing due to the development of resistance in bacteria, and thus, there is a need to search for potential alternatives to antibiotics. In this scenario, peptidoglycan hydrolases can be used
Sharma AK, Kumar S, K H, Dhakan DB, Sharma VK.   +4 more
europepmc   +18 more sources

Two New M23 Peptidoglycan Hydrolases With Distinct Net Charge [PDF]

Frontiers in Microbiology, 2021
Bacterial peptidoglycan hydrolases play an essential role in cell wall metabolism during bacterial growth, division, and elongation (autolysins) or in the elimination of closely related species from the same ecological niche (bacteriocins).
Alicja Wysocka, Elżbieta Jagielska, Łukasz Łężniak, Izabela Sabała   +3 more
doaj   +6 more sources

One fold, many functions—M23 family of peptidoglycan hydrolases [PDF]

Frontiers in Microbiology, 2022
Bacterial cell walls are the guards of cell integrity. They are composed of peptidoglycan that provides rigidity to sustain internal turgor and ensures isolation from the external environment.
Alicja Razew, Jan-Niklas Schwarz, Paweł Mitkowski, Izabela Sabala, Magdalena Kaus-Drobek   +4 more
doaj   +5 more sources

Bacterial Cell Enlargement Requires Control of Cell Wall Stiffness Mediated by Peptidoglycan Hydrolases [PDF]

mBio, 2015
Most bacterial cells are enclosed in a single macromolecule of the cell wall polymer, peptidoglycan, which is required for shape determination and maintenance of viability, while peptidoglycan biosynthesis is an important antibiotic target.
Richard Wheeler, Robert D. Turner, Richard G. Bailey, Bartłomiej Salamaga, Stéphane Mesnage, Sharifah A. S. Mohamad, Emma J. Hayhurst, Malcolm Horsburgh, Jamie K. Hobbs, Simon J. Foster   +9 more
doaj   +8 more sources

Author Correction: Coordinated peptidoglycan synthases and hydrolases stabilize the bacterial cell wall [PDF]

Nature Communications, 2023
Peptidoglycan (PG) defines cell shape and protects bacteria against osmotic stress. The growth and integrity of PG require coordinated actions between synthases that insert new PG strands and hydrolases that generate openings to allow the insertion ...
Huan Zhang, Srutha Venkatesan, Emily Ng, Beiyan Nan   +3 more
doaj   +4 more sources

Reassessing the substrate specificities of the major Staphylococcus aureus peptidoglycan hydrolases lysostaphin and LytM [PDF]

eLife
Orchestrated action of peptidoglycan (PG) synthetases and hydrolases is vital for bacterial growth and viability. Although the function of several PG synthetases and hydrolases is well understood, the function, regulation, and mechanism of action of PG ...
Lina Antenucci, Salla Virtanen, Chandan Thapa, Minne Jartti, Ilona Pitkänen, Helena Tossavainen, Perttu Permi   +6 more
doaj   +3 more sources

Engineering of Long-Circulating Peptidoglycan Hydrolases Enables Efficient Treatment of Systemic Staphylococcus aureus Infection. [PDF]

mBio, 2020
Life-threatening infections with Staphylococcus aureus are often difficult to treat due to the increasing prevalence of antibiotic-resistant bacteria and their ability to persist in protected niches in the body.
Sobieraj AM, Huemer M, Zinsli LV, Meile S, Keller AP, Röhrig C, Eichenseher F, Shen Y, Zinkernagel AS, Loessner MJ, Schmelcher M.   +10 more
europepmc   +4 more sources

Electrostatic Interaction with the Bacterial Cell Envelope Tunes the Lytic Activity of Two Novel Peptidoglycan Hydrolases [PDF]

Microbiology Spectrum, 2022
Peptidoglycan (PG) hydrolases, due to their crucial role in the metabolism of the bacterial cell wall (CW), are increasingly being considered suitable targets for therapies, and a potent alternative to conventional antibiotics.
Alicja Wysocka, Łukasz Łężniak, Elżbieta Jagielska, Izabela Sabała   +3 more
doaj   +3 more sources

A periplasmic protein modulates the proteolysis of peptidoglycan hydrolases to maintain cell wall homeostasis in <i>Escherichia coli</i>. [PDF]

Proc Natl Acad Sci U S A
Significance The bacterial cell wall needs to be expanded for growth, and this process requires the cleavage of cell wall crosslinks. While cell wall hydrolase activity is essential for this expansion, excessive activity can compromise the cell wall and ...
Park S, Jeon WJ, Lee Y, Lim CL, Lee E, Oh HB, Lee GS, Kwon OH, Ryu B, Cho YJ, Kim CS, Yoon SI, Chung JM, Cho H.   +13 more
europepmc   +3 more sources

Cell Wall Hydrolases in Bacteria: Insight on the Diversity of Cell Wall Amidases, Glycosidases and Peptidases Toward Peptidoglycan [PDF]

Frontiers in Microbiology, 2019
The cell wall (CW) of bacteria is an intricate arrangement of macromolecules, at least constituted of peptidoglycan (PG) but also of (lipo)teichoic acids, various polysaccharides, polyglutamate and/or proteins. During bacterial growth and division, there
Régine Talon, Magdalena Popowska, Mickaël Desvaux   +2 more
exaly   +3 more sources