Results 101 to 110 of about 87,420 (248)

Molecular aspects and comparative genomics of bacteriophage endolysins [PDF]

, 2013
Phages are recognized as the most abundant and diverse entities on the planet. Their diversity is predominantly determined by their dynamic adaptation capacities, when confronted with different selective pressures in an endless cycle of co-evolution with
Azeredo, Joana, Cerca, Nuno, Ferreira, E. C., Kluskens, Leon, Melo, Luís D. R., Nóbrega, Franklin Luzia, Oliveira, Hugo Alexandre Mendes, Santos, Sílvio Roberto Branco   +7 more
core   +1 more source

Novel Phage Lysin Abp013 against Acinetobacter baumannii

Antibiotics, 2022
As antimicrobial resistance (AMR) continues to pose an ever-growing global health threat, propelling us into a post-antibiotic era, novel alternative therapeutic agents are urgently required. Lysins are bacteriophage-encoded peptidoglycan hydrolases that
Joash Jun Keat Chu, Wee Han Poh, Nabilah Taqiah Binte Hasnuddin, En Yi Hew, Linh Chi Dam, Abbas El Sahili, Scott A. Rice, Boon Chong Goh   +7 more
doaj   +1 more source

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, EarlyView.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

PhiA, a Peptidoglycan Hydrolase Inhibitor of Brucella Involved in the Virulence Process [PDF]

Infection and Immunity, 2019
The peptidoglycan in Gram-negative bacteria is a dynamic structure in constant remodeling. This dynamism, achieved through synthesis and degradation, is essential because the peptidoglycan is necessary to maintain the structure of the cell but has to have enough plasticity to allow the transport and assembly of macromolecular complexes in the periplasm
del Giudice, Mariela Giselda, Romani, Alexis Mariano, Ugalde, Juan Esteban, Czibener, Cecilia   +3 more
openaire   +4 more sources

Differential gene expression in Chorthippus parallelus (Zetterstedt, 1821) (Orthoptera: Acrididae: Gomphocerinae) induced by Wolbachia infection

Insect Science, EarlyView.
Distinct lineages of the grasshopper Chorthippus parallelus (Orthoptera: Acrididae) form a well‐known hybrid zone (HZ) in the Pyrenees mountain range; the Iberian endemism C. p. erythropus (Cpe) and the subspecies C. p. parallelus, (Cpp) widely distributed throughout the rest of Europe. Both subspecies differ in diverse traits, including the strains of
Patricia Jiménez‐Florido, Mónica Aquilino, David Buckley, José L. Bella, Rosario Planelló   +4 more
wiley   +1 more source

An HWE‐Family Histidine Kinase Modulates Brucella Cell Envelope Properties and Host Innate Immune Response

Molecular Microbiology, EarlyView.
The HWE‐family histidine kinase PhyK regulates the cell envelope structure of the intracellular pathogen Brucella ovis and affects how the host immune system responds to this bacterium. Deletion of phyK alters bacterial survival in the face of detergent stress and reduces immune activation in infected macrophages.
Xingru Chen, Emily Perez, Eleanor C. Scheeres, Rosemary Northcote, Aretha Fiebig, Andrew J. Olive, Sean Crosson   +6 more
wiley   +1 more source

Relating the metatranscriptome and metagenome of the human gut [PDF]

, 2014
Although the composition of the human microbiome is now wellstudied, the microbiota’s \u3e8 million genes and their regulation remain largely uncharacterized.
Boylan, Matthew R., Chan, Andrew T., Ciulla, Dawn, Earl, Ashlee M., Franzosa, Eric A., Garrett, Wendy S., Gevers, Dirk, Giannoukos, Georgia, Huttenhower, Curtis, Izard, Jacques, Morgan, Xochitl C., Reyes, Joshua, Segata, Nicola, Waldron, Levi   +13 more
core   +2 more sources

Determining bacteriophage endopeptidase activity using either fluorophore-quencher labeled peptides combined with liquid chromatography-mass spectrometry (LC-MS) or Förster resonance energy transfer (FRET) assays. [PDF]

PLoS ONE, 2017
The necessity of identifying novel methods to combat infections caused by antibiotic resistant bacteria is increasing each year. Recent advancements in the development of peptidoglycan hydrolases (e.g. lysins) from bacterial viruses (bacteriophages) have
Rolf Lood, Henrik Molina, Vincent A Fischetti   +2 more
doaj   +1 more source

Phage and Endolysin Therapy Against Antibiotics Resistant Bacteria: From Bench to Bedside

MedComm, Volume 6, Issue 7, July 2025.
Synergistic effects of combining bacteriophages and antibiotics in antimicrobial therapy. The diagram illustrates key advantages of phage‐antibiotic synergy, including increased treatment effectiveness, reduced minimum inhibitory concentration (MIC) for drug‐resistant strains, enhanced biofilm eradication, and inhibition of resistant bacteria ...
Majid Taati Moghadam, Samane Mohebi, Raheleh Sheikhi, Meysam Hasannejad‐Bibalan, Shahla Shahbazi, Shadman Nemati   +5 more
wiley   +1 more source

Cell wall elongation mode in Gram-negative bacteria is determined by peptidoglycan architecture [PDF]

, 2013
Cellular integrity and morphology of most bacteria is maintained by cell wall peptidoglycan, the target of antibiotics essential in modern healthcare.
Cadby, A., Foster, S.J., Hobbs, J.K., Hurd, A.F., Turner, R.D.   +4 more
core   +1 more source