Results 131 to 140 of about 8,626 (154)
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Carbohydrate recognition and lysis by bacterial peptidoglycan hydrolases
Current Opinion in Structural Biology, 2017The major component of bacterial cell wall is peptidoglycan (PG), a complex polymer formed by long glycan chains cross-linked by peptide stems. PG is in constant equilibrium requiring well-orchestrated coordination between synthesis and degradation. The resulting cell-wall fragments can be recycled, act as messengers for bacterial communication, as ...
Alcorlo, Martín +3 more
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Measure of Peptidoglycan Hydrolase Activity
2017Most gene clusters encoding multiprotein complexes of the bacterial cell envelope, such as conjugation and secretion systems, Type IV pili, and flagella, bear a gene encoding an enzyme with peptidoglycan hydrolase activity. These enzymes are usually glycoside hydrolases that cleave the glycan chains of the peptidoglycan.
Yoann G, Santin, Eric, Cascales
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Peptidoglycan Hydrolases of Bacillus subtilis 168
Microbial Drug Resistance, 1996ABSTRACT There are multiple peptidoglycan hydrolases associated with Bacillus subtilis 168 and these potentially lethal enzymes have been implicated in a number of important cellular processes.
T J, Smith, S A, Blackman, S J, Foster
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Peptidoglycan hydrolases in an autolytic mutant of Salmonella typhimurium
Archives Internationales de Physiologie et de Biochimie, 1988Two peptidoglycan hydrolases were isolated from the autolytic mutant Salmonella typhimurium DA361 (envD). One of them, resistant to penicillin, was found free in the supernatant of partially purified envelopes sedimented by ultracentrifugation, and the other bound to the envelopes proved to be sensitive to the antibiotic. Both were able to hydrolyse in
R A, Pizarro, R O, Fernández, L V, Orce
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Biochemical analysis of NlpC/p60 peptidoglycan hydrolase activity
2020The NlpC/p60-family of peptidoglycan hydrolases are key enzymes that facilitate bacterial cell division and also modulate microbe-host interactions. These endopeptidases utilize conserved Cys-His residues in their active site and are expressed in most bacterial species as well as some eukaryotes.
Byungchul, Kim +2 more
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Discovery and Development of Antibacterial Peptidoglycan Hydrolase Inhibitors
ACS Infectious DiseasesThe growing number of bacterial infections and the rise of antibiotic resistance require approaches for antimicrobial development. Peptidoglycan, essential for maintaining the integrity and shape of the bacterial cell wall, is regulated by the coordinated activity of peptidoglycan synthesis and remodeling enzymes.
Kyong Tkhe Fam +2 more
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Identification of a novel peptidoglycan hydrolase CwlM in Mycobacterium tuberculosis
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2005Mycobacterium tuberculosis is a major global pathogen whose threat has increased with the emergence of multidrug-resistant strains. The cell wall of M. tuberculosis is thick, rigid, and hydrophobic, which serves to protect the organism from the environment and makes it highly impermeable to conventional antimicrobial agents. There is little known about
Lingyi Lynn, Deng +5 more
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Structural Comparison and Simulation of Pneumococcal Peptidoglycan Hydrolase LytB
2016Three-dimensional structural determination combined with comprehensive comparisons with the homologs is a straightforward strategy to decipher the molecular function of an enzyme. However, in many cases it's difficult to obtain the complex structure with the substrate/ligand.
Xiao-Hui, Bai +5 more
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Crystal structure of the glycosidase family 73 peptidoglycan hydrolase FlgJ
Biochemical and Biophysical Research Communications, 2009Glycoside hydrolase (GH) categorized into family 73 plays an important role in degrading bacterial cell wall peptidoglycan. The flagellar protein FlgJ contains N- and C-terminal domains responsible for flagellar rod assembly and peptidoglycan hydrolysis, respectively. A member of family GH-73, the C-terminal domain (SPH1045-C) of FlgJ from Sphingomonas
Wataru, Hashimoto +6 more
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Chapter 7 Microbial peptidoglycan (murein) hydrolases
1994Publisher Summary This chapter discusses the microbial peptidoglycan (murein) hydrolases. Studies of the action of lysozyme and of other bacteriolytic enzymes revealed that the bacteriolytic action was a result of hydrolysis of specific bonds in the protective and shape-maintaining bacterial exoskeleton, the peptidoglycan (murein) sacculus of the ...
G.D. Shockman, J.-V. Höltje
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