Phage-derived peptidoglycan degrading enzymes: challenges and future prospects for in vivo therapy [PDF]
, 2018 Peptidoglycan degrading enzymes are of increasing interest as antibacterial agents, especially against multi-drug resistant pathogens. Herein we present a review about the biological features of virion-associated lysins and endolysins, phage-derived ...
Azeredo, Joana +2 more
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Listeria bacteriophage peptidoglycan hydrolases feature high thermoresistance and reveal increased activity after divalent metal cation substitution [PDF]
, 2018 The ability of the bacteriophage-encoded peptidoglycan hydrolases (endolysins) to destroy Gram-positive bacteria from without makes these enzymes promising antimicrobials.
Loessner, Martin +2 more
core
Mur1, aStreptococcus thermophiluspeptidoglycan hydrolase devoid of a specific cell wall binding domain [PDF]
, 2000 Clara Husson-Kao +3 more
openalex +2 more sources
Comprehensive analysis of peptidoglycan hydrolases in Caulobacter crescentus [PDF]
, 2016 The peptidoglycan (PG) sacculus is a large macromolecule enclosing most bacterial cells. During progression of the cell cycle, it needs to be continuously remodelled to enable elongation of the cell body and, finally, cell division.
Zielinska, Aleksandra +1 more
openaire +2 more sources
Biochemical Characterization of Diamide Inhibitors with N-acetylglucosaminidases LytG from Bacillus subtilis [PDF]
, 2016 In recent years the frequency of antibiotic resistance has been on the rise creating a need for antibiotic development with specific and lethal targets.
Phelan, Drew
core +1 more source
Engineered bacteriophage lysins as novel anti-infectives
Frontiers in Microbiology, 2014 Bacteriophage lysins, the highly evolved special peptidoglycan hydrolases, have long been demonstrated to be an effective enzybiotics in various infectious models. The modular structure of lysins makes it possible to design bioengineered lysins that have
hang eyang, junping eyu, Hongping eWei
doaj +1 more source
Peptidoglycan Remodeling and Conversion of an Inner Membrane into an Outer Membrane during Sporulation [PDF]
, 2011 Two hallmarks of the Firmicute phylum, which includes the Bacilli and Clostridia classes, are their ability to form endospores and their “Gram-positive” single-membraned, thick-cell-wall envelope structure.
Jensen, Grant J. +5 more
core +1 more source
Interactions between Bacteria and Bile Salts in the Gastrointestinal and Hepatobiliary Tracts [PDF]
, 2017 Bile salts and bacteria have intricate relationships. The composition of the intestinal pool of bile salts is shaped by bacterial metabolism. In turn, bile salts play a role in intestinal homeostasis by controlling the size and the composition of the ...
Casadesús Pursals, Josep +1 more
core +1 more source
Deletion of Lytic Transglycosylases Increases Beta-Lactam Resistance in Shewanella oneidensis
Frontiers in Microbiology, 2018 Production of chromosome-encoded β-lactamases confers resistance to β-lactams in many Gram-negative bacteria. Some inducible β-lactamases, especially the class C β-lactamase AmpC in Enterobacteriaceae, share a common regulatory mechanism, the ampR-ampC ...
Jianhua Yin +7 more
doaj +1 more source
NlpC/P60 domain-containing proteins of Mycobacterium avium subspecies paratuberculosis that differentially bind and hydrolyze peptidoglycan [PDF]
, 2016 A subset of proteins containing NlpC/P60 domains are bacterial peptidoglycan hydrolases that cleave noncanonical peptide linkages and contribute to cell wall remodeling as well as cell separation during late stages of division.
Adam, Philip R. +7 more
core +2 more sources