Archaea produce peptidoglycan hydrolases that kill bacteria [PDF]
PLoS BiologyThe social life of archaea is poorly understood. In particular, even though competition and conflict are common themes in microbial communities, there is scant evidence documenting antagonistic interactions between archaea and their abundant prokaryotic brethren: bacteria. Do archaea specifically target bacteria for destruction?
Romain Strock +6 more
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Enhancing stability and safety of chimeric peptidoglycan hydrolases by linker engineering [PDF]
Applied Microbiology and BiotechnologySpread of antimicrobial resistance and lack of new antibiotics have brought attention to alternative strategies of combating pathogenic bacteria. One of these strategies takes advantage of the bacteriolytic activity of peptidoglycan hydrolases.
Paweł Mitkowski +6 more
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Coordinated peptidoglycan synthases and hydrolases stabilize the bacterial cell wall
Nature Communications, 2023 Peptidoglycan (PG) defines cell shape and protects bacteria against osmotic stress. The growth and integrity of PG require coordinated actions between synthases that insert new PG strands and hydrolases that generate openings to allow the insertion ...
Huan Zhang +3 more
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Antibacterial and anti-biofilm activity of diarylureas against Enterococcus faecium by suppressing the gene expression of peptidoglycan hydrolases and adherence. [PDF]
Front Microbiol, 2022 Xie Y +7 more
europepmc +3 more sources
A periplasmic protein modulates the proteolysis of peptidoglycan hydrolases to maintain cell wall homeostasis in <i>Escherichia coli</i>. [PDF]
Proc Natl Acad Sci U S APark S +13 more
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Chimeric Peptidoglycan Hydrolases Kill Staphylococcal Mastitis Isolates in Raw Milk and within Bovine Mammary Gland Epithelial Cells. [PDF]
Viruses, 2022 Keller AP +5 more
europepmc +3 more sources
Regulation of peptidoglycan hydrolases: localization, abundance, and activity. [PDF]
Curr Opin Microbiol, 2023 Most bacteria are surrounded by a cell wall composed of peptidoglycan (PG) that specifies shape and protects the cell from osmotic rupture. Growth, division, and morphogenesis are intimately linked to the synthesis of this exoskeleton but also its hydrolysis. The enzymes that cleave the PG meshwork require careful control to prevent aberrant hydrolysis
Brogan AP, Rudner DZ.
europepmc +3 more sources
Peptidoglycan Hydrolase Fusions Maintain Their Parental Specificities [PDF]
Applied and Environmental Microbiology, 2006 ABSTRACT The increased incidence of bacterial antibiotic resistance has led to a renewed search for novel antimicrobials. Avoiding the use of broad-range antimicrobials through the use of specific peptidoglycan hydrolases (endolysins) might reduce the incidence of antibiotic-resistant pathogens worldwide.
David M. Donovan +5 more
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Peptidoglycan hydrolases of Escherichia coli. [PDF]
Microbiol Mol Biol Rev, 2011 SUMMARYThe review summarizes the abundant information on the 35 identified peptidoglycan (PG) hydrolases ofEscherichia coliclassified into 12 distinct families, including mainly glycosidases, peptidases, and amidases. An attempt is also made to critically assess their functions in PG maturation, turnover, elongation, septation, and recycling as well as
van Heijenoort J.
europepmc +4 more sources
A holin/peptidoglycan hydrolase‐dependent protein secretion system [PDF]
Molecular Microbiology, 2020 AbstractGram‐negative bacteria have evolved numerous pathways to secrete proteins across their complex cell envelopes. Here, we describe a protein secretion system that uses a holin membrane protein in tandem with a cell wall‐editing enzyme to mediate the secretion of substrate proteins from the periplasm to the cell exterior.
Tracy Palmer +4 more
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