Identification of the chain-dispersing peptidoglycan hydrolase LytB of Streptococcus gordonii. [PDF]
PLoS ONE, 2017 Bacterial cell division ends with the separation of the daughter cells, a process that requires peptidoglycan hydrolases (PGHs). Bacteria lacking cell separating PGHs are impaired in cell separation with the formation of long chains or clusters.
Riccardo Arrigucci, Gianni Pozzi
doaj +6 more sources
Engineering of Long-Circulating Peptidoglycan Hydrolases Enables Efficient Treatment of Systemic Staphylococcus aureus Infection. [PDF]
mBio, 2020 Sobieraj AM +10 more
europepmc +3 more sources
Regulation of peptidoglycan hydrolases: localization, abundance, and activity. [PDF]
Curr Opin Microbiol, 2023 Most bacteria are surrounded by a cell wall composed of peptidoglycan (PG) that specifies shape and protects the cell from osmotic rupture. Growth, division, and morphogenesis are intimately linked to the synthesis of this exoskeleton but also its hydrolysis. The enzymes that cleave the PG meshwork require careful control to prevent aberrant hydrolysis
Brogan AP, Rudner DZ.
europepmc +3 more sources
A new peptidoglycan hydrolase inStreptococcus pneumoniae [PDF]
FEMS Microbiology Letters, 1986 The use of a mutant of Streptococcus pneumoniae deleted in the lytA gene coding for the N-acetyl-muramyl-l-alanine amidase, and therefore devoid of any amidase, has allowed the identification of a new murein hydrolase activity in this bacterium. This enzyme (or enzymes) acted as an autolysin when the cultures were grown at 30°C.
J.M. SaÅchez-Puelles +5 more
openalex +3 more sources
Two new enzymes that liberate undecaprenyl-phosphate to replenish the carrier lipid pool during envelope stress [PDF]
mBioThe 55-carbon isoprenoid, undecaprenyl-phosphate (UndP), is a universal carrier lipid that ferries most glycans and glycopolymers across the cytoplasmic membrane in bacteria.
Ian J. Roney, David Z. Rudner
doaj +2 more sources
Cell Wall Hydrolases in Bacteria: Insight on the Diversity of Cell Wall Amidases, Glycosidases and Peptidases Toward Peptidoglycan [PDF]
Frontiers in Microbiology, 2019 Régine Talon +2 more
exaly +2 more sources
Peptidoglycan hydrolases of Escherichia coli. [PDF]
Microbiol Mol Biol Rev, 2011 SUMMARYThe review summarizes the abundant information on the 35 identified peptidoglycan (PG) hydrolases ofEscherichia coliclassified into 12 distinct families, including mainly glycosidases, peptidases, and amidases. An attempt is also made to critically assess their functions in PG maturation, turnover, elongation, septation, and recycling as well as
van Heijenoort J.
europepmc +5 more sources
Identification and characterization of a peptidoglycan hydrolase from Rhodobacter johrii [PDF]
, 2021 Abstract The bacterial whole genome sequences are available in the database therefore explored for the varieties of known and unknown proteins. Bacteria harbor various peptidoglycan hydrolases that cleave peptidoglycan and play an important role in the cell division, growth, spore differentiation and development. In the present study, we report
Ashif Ali, Sasikala Ch, Ch. V. Ramana
openalex +4 more sources
Bacterial peptidoglycan (murein) hydrolases [PDF]
FEMS Microbiology Reviews, 2008 Most bacteria have multiple peptidoglycan hydrolases capable of cleaving covalent bonds in peptidoglycan sacculi or its fragments. An overview of the different classes of peptidoglycan hydrolases and their cleavage sites is provided. The physiological functions of these enzymes include the regulation of cell wall growth, the turnover of peptidoglycan ...
Waldemar Vollmer +3 more
openalex +5 more sources
Comprehensive analysis of peptidoglycan hydrolases in Caulobacter crescentus [PDF]
, 2016 The peptidoglycan (PG) sacculus is a large macromolecule enclosing most bacterial cells. During progression of the cell cycle, it needs to be continuously remodelled to enable elongation of the cell body and, finally, cell division. This process requires
Zielinska, Aleksandra
core +3 more sources