Peptidoglycan hydrolases-potential weapons against Staphylococcus aureus. [PDF]
Appl Microbiol Biotechnol, 2012 Bacteria of the genus Staphylococcus are common pathogens responsible for a broad spectrum of human and animal infections and belong to the most important etiological factors causing food poisoning. Because of rapid increase in the prevalence of isolation of staphylococci resistant to many antibiotics, there is an urgent need for the development of new
Szweda P +5 more
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Recent Advances in Peptidoglycan Synthesis and Regulation in Bacteria
Biomolecules, 2023 Bacteria must synthesize their cell wall and membrane during their cell cycle, with peptidoglycan being the primary component of the cell wall in most bacteria.
Anne Galinier +4 more
doaj +1 more source
Staphylococcus aureus sacculus mediates activities of M23 hydrolases
Nature Communications, 2023 Peptidoglycan, a gigadalton polymer, functions as the scaffold for bacterial cell walls and provides cell integrity. Peptidoglycan is remodelled by a large and diverse group of peptidoglycan hydrolases, which control bacterial cell growth and division ...
Alicja Razew +6 more
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Antibiotics, 2021 Over the past few decades, we have witnessed a surge around the world in the emergence of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and misuse of antibiotics as well as a relative lack of new drug classes in
Katarzyna M. Danis-Wlodarczyk +2 more
doaj +1 more source
A holin/peptidoglycan hydrolase‐dependent protein secretion system [PDF]
Molecular Microbiology, 2020 AbstractGram‐negative bacteria have evolved numerous pathways to secrete proteins across their complex cell envelopes. Here, we describe a protein secretion system that uses a holin membrane protein in tandem with a cell wall‐editing enzyme to mediate the secretion of substrate proteins from the periplasm to the cell exterior.
Tracy Palmer +4 more
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Structural basis of the novel S. pneumoniae virulence factor, GHIP, a glycosyl hydrolase 25 participating in host-cell invasion. [PDF]
PLoS ONE, 2013 Pathogenic bacteria produce a wide variety of virulence factors that are considered to be potential antibiotic targets. In this study, we report the crystal structure of a novel S.
Siqiang Niu +15 more
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The hydrolase LpqI primes mycobacterial peptidoglycan recycling [PDF]
Nature Communications, 2018 AbstractGrowth and division by most bacteria requires remodelling and cleavage of their cell wall. A byproduct of this process is the generation of free peptidoglycan (PG) fragments known as muropeptides, which are recycled in many model organisms. Bacteria and hosts can harness the unique nature of muropeptides as a signal for cell wall damage and ...
Andrew L. Lovering +9 more
openaire +7 more sources
Characterisation of a putative M23-domain containing protein in Mycobacterium tuberculosis.
PLoS ONE, 2021 Mycobacterium tuberculosis, the causative agent of tuberculosis remains a global health concern, further compounded by the high rates of HIV-TB co-infection and emergence of multi- and extensive drug resistant TB, all of which have hampered efforts to ...
Andrea Olga Papadopoulos +4 more
doaj +2 more sources
The Integrity of the Cell Wall and Its Remodeling during Heterocyst Differentiation Are Regulated by Phylogenetically Conserved Small RNA Yfr1 in Nostoc sp. Strain PCC 7120 [PDF]
, 2020 Yfr1 is a strictly conserved small RNA in cyanobacteria. A bioinformatic prediction to identify possible interactions of Yfr1 with mRNAs was carried out by using the sequences of Yfr1 from several heterocyst-forming strains, including Nostoc sp.
Brenes Álvarez, Manuel +2 more
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More than just lysins: peptidoglycan hydrolases tailor the cell wall [PDF]
Current Opinion in Microbiology, 2011 Tsuyoshi Uehara +2 more
exaly +2 more sources