Results 51 to 60 of about 8,551 (180)

An exhaustive multiple knockout approach to understanding cell wall hydrolase function in Bacillus subtilis

mBio, 2023
Most bacteria are surrounded by their cell wall, containing a highly cross-linked protective envelope of peptidoglycan. To grow, bacteria must continuously remodel their wall, inserting new material and breaking old bonds.
Sean A. Wilson, Raveen K. J. Tank, Jamie K. Hobbs, Simon J. Foster, Ethan C. Garner   +4 more
doaj   +1 more source

Emergence of Staphylococcus aureus Resistance to Antimicrobial Peptides Nisin, NZ2114 and Bacitracin Involves Multiple Phenotypic Changes

Animal Research and One Health, EarlyView.
The AMP‐induced mutant Staphylococcus aureus strain nzR showed increased resistance, five gene mutations, and decreased surface anion levels. AMPs affect the NDH‐2 protein encoded by ndh gene inhibiting the growth of S. aureus. The deletion of the ndh gene promotes the development of AMPs resistance.
Lingyu Xiao, Xingyuan Ma, Ping Tian, Lianbin Li, Zafir Muhammad, Xiaokun Wang, Xuemei Xue, Jinhe Xiao, Liangjun Zheng, F. A. El‐Gohary, Xin Zhao, Junning Pu, Huping Xue   +12 more
wiley   +1 more source

The role of the gut microbiome in the regulation of high‐altitude adaptation

iMeta, EarlyView.
This study is the first to elucidate mechanisms of high‐altitude adaptation from the perspective of the rumen ecosystem by using indigenous yaks and Holstein cows that have lived at high altitude since birth as comparative models. Through a systematic comparison of their rumen ecology using multi‐omics approaches—including rumen metagenomics ...
Xinyu Zhang, Senlin Zhu, Michael Kreuzer, Shoukun Ji, Wei Wang, Yanliang Bi, Shengli Li   +6 more
wiley   +1 more source

Bacterial Extracellular Vesicles in the Pathogenesis and Treatment of Liver Diseases

Journal of Gastroenterology and Hepatology, EarlyView.
Liver diseases are a major global health challenge, with current treatments inadequate. This review highlights the role of bacterial extracellular vesicles in liver inflammation, fibrosis, and metabolism. We also explore these from commensals and probiotics, their protective effects, and discuss research challenges and future therapeutic potential ...
Yakun Li, Jia Li, Robin P. F. Dullaart, Han Moshage   +3 more
wiley   +1 more source

A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens [PDF]

Science, 2016
The intestinal microbiome modulates host susceptibility to enteric pathogens, but the specific protective factors and mechanisms of individual bacterial species are not fully characterized. We show that secreted antigen A (SagA) from Enterococcus faecium is sufficient to protect Caenorhabditis elegans
Kavita J, Rangan, Virginia A, Pedicord, Yen-Chih, Wang, Byungchul, Kim, Yun, Lu, Shai, Shaham, Daniel, Mucida, Howard C, Hang   +7 more
openaire   +2 more sources

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Dual role for the O-acetyltransferase OatA in peptidoglycan modification and control of cell septation in Lactobacillus plantarum. [PDF]

PLoS ONE, 2012
Until now, peptidoglycan O-acetyl transferases (Oat) were only described for their peptidoglycan O-acetylating activity and for their implication in the control of peptidoglycan hydrolases.
Elvis Bernard, Thomas Rolain, Blandine David, Guillaume André, Vincent Dupres, Yves F Dufrêne, Bernard Hallet, Marie-Pierre Chapot-Chartier, Pascal Hols   +8 more
doaj   +1 more source

The Factors Involved in Plant–Insect–Microbe Interactions Expanded: Genome Analysis and Description of Frigoribacterium adelgis sp. nov.

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
Aerobic Actinobacteria belonging to the genus Frigoribacterium were isolated from adelgid Adelges (Aphrastasia) pectinatae collected from a Korean fir tree. Genomic analysis showed that these bacteria encode a range of factors that may be involved in the interactions between Frigoribacterium strains, adelgids and/or Korean fir trees.
Gustė Tamošiūnaitė, Jekaterina Havelka, Raimonda Baranauskienė, Justas Lazutka, Nomeda Kuisiene   +4 more
wiley   +1 more source

Mycobacterium tuberculosis FtsX extracellular domain activates the peptidoglycan hydrolase, RipC [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance During growth and division, bacterial cells partition the cell wall to daughter cells, but the “inside-out” signals that regulate peptidoglycan (PG) hydrolysis are not well understood. Our studies of mycobacterial proteins achieve in vitro reconstitution of the regulation of the PG hydrolase, RipC, by the FtsX extracellular ...
Mavrici, Daniela, Marakalala, Mohlopheni J., Holton, James M., Prigozhin, Daniil M., Gee, Christine L., Zhang, Yanjia J., Rubin, Eric J., Alber, Tom   +7 more
openaire   +4 more sources

Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction.

PLoS Pathogens, 2021
Peptidoglycan is the major structural component of the Staphylococcus aureus cell wall, in which it maintains cellular integrity, is the interface with the host, and its synthesis is targeted by some of the most crucial antibiotics developed.
Joshua A F Sutton, Oliver T Carnell, Lucia Lafage, Joe Gray, Jacob Biboy, Josie F Gibson, Eric J G Pollitt, Simone C Tazoll, William Turnbull, Natalia H Hajdamowicz, Bartłomiej Salamaga, Grace R Pidwill, Alison M Condliffe, Stephen A Renshaw, Waldemar Vollmer, Simon J Foster   +15 more
doaj   +1 more source