Results 61 to 70 of about 11,815 (217)
Molecular imaging of glycan chains couples cell-wall polysaccharide architecture to bacterial cell [PDF]
, 2018 Biopolymer composite cell walls maintain cell shape and resist forces in plants, fungi and bacteria. Peptidoglycan, a crucial antibiotic target and immunomodulator, performs this role in bacteria.
A Typas +40 more
core +2 more sources
In vitro destruction of Streptococcus pneumoniae biofilms with bacterial and phage peptidoglycan hydrolases. [PDF]
Antimicrob Agents Chemother, 2011 ABSTRACTHost- and phage-coded cell wall hydrolases have been used to fightStreptococcus pneumoniaegrowing as planktonic cellsin vitroas well as in animal models. Until now, however, the usefulness of these enzymes in biofilm-grown pneumococci has gone untested. The antipneumococcal activity of different cell wall hydrolases produced byS.
Domenech M, García E, Moscoso M.
europepmc +7 more sources
Detection and Localization of a Peptidoglycan Hydrolase in Lactobacillus delbrueckiisubsp. bulgaricus [PDF]
Journal of Dairy Science, 2003 Peptidoglycan hydrolase activities in Lactobacillus delbrueckii subsp. bulgaricus were detected by analysis of bacterial extracts on denaturing polyacrylamide gel electrophoresis containing lyophilized Micrococcus lysodeikticus cells as substrate. A hydrolase with an estimated molecular mass of 80 kDa was found to cross-react on Western blot with ...
O.J. Kang, Ronald E. Simard, S. Laberge
openaire +3 more sources
Structural Insights into the Effector - Immunity System Tae4/Tai4 from Salmonella typhimurium. [PDF]
PLoS ONE, 2013 Type-6-secretion systems of Gram-negative bacteria are widely distributed needle-like multi-protein complexes that are involved in microbial defense mechanisms.
Juliane Benz +2 more
doaj +1 more source
Bacteriophage virion-associated peptidoglycan hydrolases: potential new enzybiotics [PDF]
Critical Reviews in Microbiology, 2012 Virion-associated peptidoglycan hydrolases (VAPGH) are phage-encoded lytic enzymes that locally degrade the peptidoglycan (PG) of the bacterial cell wall during infection. In contrast to endolysins, PGHs that mediate lysis of the host bacteria at the end of the lytic cycle to release of phage progeny, the action of VAPGHs generates a small hole through
Rodríguez, Lorena +4 more
openaire +4 more sources
mBio, 2015 Bacterial SH3 (SH3b) domains are commonly fused with papain-like Nlp/P60 cell wall hydrolase domains. To understand how the modular architecture of SH3b and NlpC/P60 affects the activity of the catalytic domain, three putative NlpC/P60 cell wall ...
Qingping Xu +13 more
doaj +1 more source
A Proteolytic Complex Targets Multiple Cell Wall Hydrolases in
mBio, 2018 Carboxy-terminal processing proteases (CTPs) occur in all three domains of life. In bacteria, some of them have been associated with virulence. However, the precise roles of bacterial CTPs are poorly understood, and few direct proteolytic substrates have
Disha Srivastava +5 more
doaj +1 more source
mBio, 2023 Most bacteria are surrounded by their cell wall, containing a highly cross-linked protective envelope of peptidoglycan. To grow, bacteria must continuously remodel their wall, inserting new material and breaking old bonds.
Sean A. Wilson +4 more
doaj +1 more source
Reduced peptidoglycan synthesis capacity impairs growth of E. coli at high salt concentration
mBioGram-negative bacteria have a thin peptidoglycan layer between the cytoplasmic and outer membranes protecting the cell from osmotic challenges. Hydrolases of this structure are needed to cleave bonds to allow the newly synthesized peptidoglycan strands ...
Dema Alodaini +11 more
doaj +1 more source
eLife, 2019 Bacterial cells are encased in a peptidoglycan (PG) exoskeleton that protects them from osmotic lysis and specifies their distinct shapes. Cell wall hydrolases are required to enlarge this covalently closed macromolecule during growth, but how these ...
Genevieve S Dobihal +3 more
doaj +1 more source