Imbalance of peptidoglycan biosynthesis alters the cell surface charge of Listeria monocytogenes
The Cell Surface, 2022 The bacterial cell wall is composed of a thick layer of peptidoglycan and cell wall polymers, which are either embedded in the membrane or linked to the peptidoglycan backbone and referred to as lipoteichoic acid (LTA) and wall teichoic acid (WTA ...
Lisa Maria Schulz +4 more
doaj
Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles’ heel for the TB-causing pathogen [PDF]
, 2019 Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis, remains one of the leading causes of mortality across the world. There is an urgent requirement to build a robust arsenal of effective antimicrobials, targeting novel ...
Bhakta, S +6 more
core +2 more sources
Dual role for the O-acetyltransferase OatA in peptidoglycan modification and control of cell septation in Lactobacillus plantarum. [PDF]
PLoS ONE, 2012 Until now, peptidoglycan O-acetyl transferases (Oat) were only described for their peptidoglycan O-acetylating activity and for their implication in the control of peptidoglycan hydrolases.
Elvis Bernard +8 more
doaj +1 more source
Identification of a New Family of Enzymes with Potential \u3cem\u3eO\u3c/em\u3e-acetylpeptidoglycan esterase activity in both Gram-positive and Gram-negative bacteria [PDF]
, 2005 Background: The metabolism of the rigid bacterial cell wall heteropolymer peptidoglycan is a dynamic process requiring continuous biosynthesis and maintenance involving the coordination of both lytic and synthetic enzymes.
Clarke, Anthony J. +2 more
core +1 more source
DipM, a new factor required for peptidoglycan remodelling during cell division in Caulobacter crescentus [PDF]
, 2010 In bacteria, cytokinesis is dependent on lytic enzymes that facilitate remodelling of the cell wall during constriction. In this work, we identify a thus far uncharacterized periplasmic protein, DipM, that is required for cell division and polarity in ...
Briegel, Ariane +4 more
core +1 more source
Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction.
PLoS Pathogens, 2021 Peptidoglycan is the major structural component of the Staphylococcus aureus cell wall, in which it maintains cellular integrity, is the interface with the host, and its synthesis is targeted by some of the most crucial antibiotics developed.
Joshua A F Sutton +15 more
doaj +1 more source
Novel Phage Lysin Abp013 against Acinetobacter baumannii
Antibiotics, 2022 As antimicrobial resistance (AMR) continues to pose an ever-growing global health threat, propelling us into a post-antibiotic era, novel alternative therapeutic agents are urgently required. Lysins are bacteriophage-encoded peptidoglycan hydrolases that
Joash Jun Keat Chu +7 more
doaj +1 more source
PhiA, a Peptidoglycan Hydrolase Inhibitor of Brucella Involved in the Virulence Process [PDF]
Infection and Immunity, 2019 The peptidoglycan in Gram-negative bacteria is a dynamic structure in constant remodeling. This dynamism, achieved through synthesis and degradation, is essential because the peptidoglycan is necessary to maintain the structure of the cell but has to have enough plasticity to allow the transport and assembly of macromolecular complexes in the periplasm
del Giudice, Mariela Giselda +3 more
openaire +4 more sources
Molecular aspects and comparative genomics of bacteriophage endolysins [PDF]
, 2013 Phages are recognized as the most abundant and diverse entities on the planet. Their diversity is predominantly determined by their dynamic adaptation capacities, when confronted with different selective pressures in an endless cycle of co-evolution with
Azeredo, Joana +7 more
core +1 more source
Bacteriophage endolysins as a response to emerging foodborne pathogens [PDF]
, 2012 Continuous reports on foodborne outbreaks and increasing prevalence of antibiotic-resistant bacteria call for the development of novel preservation techniques that assure the safety of food products.
Azeredo, Joana +3 more
core +1 more source