Results 201 to 210 of about 26,717 (273)

Update on Structure and Function of SH2 Domains: Mechanisms and Emerging Targeting Strategies. [PDF]

Int J Mol Sci
Kasembeli MM, Rodas J, Tweardy DJ.
europepmc   +1 more source

The 'ins' and 'outs' of amidines in β-sheet folding and fibril disaggregation. [PDF]

Chem Sci
O'Brien EA, Abbasi M, Purslow JA, VanVeller B.   +3 more
europepmc   +1 more source

Targeting the undruggable transcription factor, KLF5, with a peptidomimetic small molecule, NC114, attenuates pressure overload-induced cardiac remodeling and fibrosis. [PDF]

Sci Rep
Methatham T, Kimura N, Tomida S, Ishima T, Taguchi Y, Uosaki H, Sakashita E, Endo H, Nagai R, Aizawa K.   +9 more
europepmc   +1 more source

Development of Peptidomimetic Inhibitors of the ERG Gene Fusion Product in Prostate Cancer. [PDF]

Cancer Cell
Wang X, Qiao Y, Asangani IA, Ateeq B, Poliakov A, Cieślik M, Pitchiaya S, Chakravarthi BVSK, Cao X, Jing X, Wang CX, Apel IJ, Wang R, Ching-Yi Tien J, Juckette KM, Yan W, Jiang H, Wang S, Varambally S, Chinnaiyan AM.   +19 more
europepmc   +1 more source

Novel Peptidomimetic Cyclo-{E(I)-E(W)}Na (CP-88) with Hematopoietic Activity Sustained in Invasive and Oral Administration: Experimental and Preclinical Evaluation. [PDF]

Int J Mol Sci
Deigin V, Vinogradova Y, Vinogradov D, Linkova N, Dyatlova A, Medvedev D, Krasichkov A, Polyakova V.   +7 more
europepmc   +1 more source

Dual Inhibitors of SARS-CoV-2 3CL Protease and Human Cathepsin L Containing Glutamine Isosteres Are Anti-CoV-2 Agents. [PDF]

J Am Chem Soc
Kumar V, Zhu J, Chenna BC, Hoffpauir ZA, Rademacher A, Rogers AM, Tseng CT, Drelich A, Farzandh S, Lamb AL, Meek TD.   +10 more
europepmc   +1 more source

In silico studies of the open form of human tissue transglutaminase. [PDF]

Sci Rep
Ivashchenko SD, Shulga DA, Ivashchenko VD, Zinovev EV, Vlasov AV.   +4 more
europepmc   +1 more source

Caspase-mediated pathways in retinal ganglion cell injury: a novel therapeutic target for glaucoma. [PDF]

Front Cell Dev Biol
Rajakrishna N, Lim ST, Wang X, Wong TT.
europepmc   +1 more source

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Peptidomimetic Polyurethanes Inhibit Bacterial Biofilm Formation and Disrupt Surface Established Biofilms

Journal of the American Chemical Society, 2021
Over 80% of all chronic bacterial infections in humans are associated with biofilms, which are surface-associated bacterial communities encased within a secreted exopolysaccharide matrix that can provide resistance to environmental and chemical insults ...
Apoorva Vishwakarma, Francis Dang, Allison Ferrell   +2 more
exaly   +2 more sources

Peptidomimetic toolbox for drug discovery

Chemical Society Reviews, 2020
The art of transforming peptides into drug leads is still a dynamic and fertile field in medicinal chemistry and drug discovery. Peptidomimetics can respond to peptide limitations by displaying higher metabolic stability, good bioavailability and ...
Elena Lenci, Andrea Trabocchi
exaly   +2 more sources