Results 101 to 110 of about 33,890 (233)

Mechanism of ribosome rescue by ArfA and RF2

eLife, 2017
ArfA rescues ribosomes stalled on truncated mRNAs by recruiting release factor RF2, which normally binds stop codons to catalyze peptide release. We report two 3.2 Å resolution cryo-EM structures – determined from a single sample – of the 70S ribosome ...
Gabriel Demo, Egor Svidritskiy, Rohini Madireddy, Ruben Diaz-Avalos, Timothy Grant, Nikolaus Grigorieff, Duncan Sousa, Andrei A Korostelev   +7 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

The GTPase Nog1 co-ordinates the assembly, maturation and quality control of distant ribosomal functional centers

eLife, 2020
Eukaryotic ribosome precursors acquire translation competence in the cytoplasm through stepwise release of bound assembly factors, and proofreading of their functional centers.
Purnima Klingauf-Nerurkar, Ludovic C Gillet, Daniela Portugal-Calisto, Michaela Oborská-Oplová, Martin Jäger, Olga T Schubert, Agnese Pisano, Cohue Peña, Sanjana Rao, Martin Altvater, Yiming Chang, Ruedi Aebersold, Vikram G Panse   +12 more
doaj   +1 more source

Citrullination in Tumor Metastasis, Inside and Outside the Cells

Cancer Science, Volume 116, Issue 12, Page 3239-3249, December 2025.
ABSTRACT Tumor metastasis remains a poor prognosis because it occurs in all tissues and is difficult to diagnose or prevent before metastatic tumor nodules form. Metastasis is a multi‐step process involving tumor cells, bone marrow‐derived cells, and tissue resident cells, making it a biological three‐body problem.
Takeshi Tomita, Priyanka Sharma, Sachie Hiratsuka   +2 more
wiley   +1 more source

Genome-wide profiling of human cap-independent translation-enhancing elements. [PDF]

, 2013
We report an in vitro selection strategy to identify RNA sequences that mediate cap-independent initiation of translation. This method entails mRNA display of trillions of genomic fragments, selection for initiation of translation and high-throughput ...
Briones, Natalia, Chaput, John C, Jacobs, Bertram L, Kukurba, Kim, Kumar, Sudhir, Larsen, Andrew C, Liu, Li, Snyder, Michael, Stephens, Bret, Waern, Karl, Wellensiek, Brian P   +10 more
core  

Effect of cytidine‐5′‐monophosphate on peptidyl transferase activity [PDF]

FEBS Letters, 1975
The transfer reaction with pA-fMet as a donor substrate is strongly stimulated by CMP, whereas the transfer reaction with CpApCpCpA-acLeu as a donor substrate is inhibited by CMP. These results indicate that the donor site of peptidyl transferase contains specific binding sites for the terminal adenosine and for the cytidylic acid residue in the ...
openaire   +2 more sources

Target of rapamycin signaling in pea embryos is dependent on glutamine but detached from seed storage protein biosynthesis

New Phytologist, Volume 248, Issue 6, Page 2833-2849, December 2025.
Summary Target of rapamycin (TOR) kinase is the hub of a eukaryotic master signaling network that integrates nutritional and hormonal signals into cellular activities. Most studies on TOR in plants have focused on seedlings, where TOR is most responsive to light and sucrose.
Brendan M. O'Leary, Suvi Honkanen, Vinti Kumari, Christoph Rampitsch, Eiji Nambara, A. Harvey Millar   +5 more
wiley   +1 more source

Further Characterization of the Pseudo-Symmetrical Ribosomal Region

Life, 2020
The peptidyl transferase center of the modern ribosome has been found to encompass an area of twofold pseudosymmetry (SymR). This observation strongly suggests that the very core of the ribosome arose from a dimerization event between two modest-sized ...
Mario Rivas, George E. Fox
doaj   +1 more source

Restriction Site-Free Insertion of PCR Products Directionally into Vectors

BioTechniques, 2000
A restriction site-free cloning method has been developed for inserting a PCR product into a vector flexibly and precisely at any desired location with high efficiency. The method uses a pair of DNA integration primers with two portions.
G.J. Chen, N. Qiu, C. Karrer, P. Caspers, M.G.P. Page   +4 more
doaj   +1 more source

Template-directed biopolymerization: tape-copying Turing machines

, 2012
DNA, RNA and proteins are among the most important macromolecules in a living cell. These molecules are polymerized by molecular machines. These natural nano-machines polymerize such macromolecules, adding one monomer at a time, using another linear ...
Chowdhury, Debashish, Sharma, Ajeet K.
core   +1 more source