Protecting the proteome: Eukaryotic cotranslational quality control pathways. [PDF]
, 2014 The correct decoding of messenger RNAs (mRNAs) into proteins is an essential cellular task. The translational process is monitored by several quality control (QC) mechanisms that recognize defective translation complexes in which ribosomes are stalled on
Bennett, Eric J, Lykke-Andersen, Jens
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Structural and mutational analysis of the ribosome-arresting human XBP1u
eLife, 2019 XBP1u, a central component of the unfolded protein response (UPR), is a mammalian protein containing a functionally critical translational arrest peptide (AP). Here, we present a 3 Å cryo-EM structure of the stalled human XBP1u AP. It forms a unique turn
Vivekanandan Shanmuganathan +10 more
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Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. [PDF]
, 2012 BACKGROUND The intricate interactions between the immune, endocrine and central nervous systems shape the innate immune response of the brain. We have previously shown that estradiol suppresses expression of immune genes in the frontal cortex of ...
Carl Cotman +8 more
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The effect of gougerotin analogues on ribosomal peptidyl transferase
FEBS Letters, 1971 1. Introduction Gougerotin (I), a dipeptidyl pyrimidine nucleoside antibiotic, has been found to specifically inhibit the step of protein biosynthesis which is catalyzed by ribosomal peptidyl transferase [l-S] . Since three gougerotin analogues have been synthesized recently [6] , 1-[3(sarcosyl-D-seryl-)amino3-deoxy$-D-gluco- pyranosyl-)uracil (II, cf.
Černá, J. +2 more
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Effect of the presence of a pCpCpCA 3′-terminus in Phe-tRNAPheyeast on the interaction with elongation factors and with the poly U-ribosome system [PDF]
, 1972 Ce n’est certes pas un hasard si dans l’ensemble des textes de Tabucchi une forte concentration autour de la figure de Pessoa s’opère dans la période qui précède Sostiene Pereira (1994), texte-pivot dans l’évolution de sa conception de la littérature. Il
Thang +13 more
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Cell Reports, 2014 Termination and ribosome recycling are essential processes in translation. In eukaryotes, a stop codon in the ribosomal A site is decoded by a ternary complex consisting of release factors eRF1 and guanosine triphosphate (GTP)-bound eRF3.
Anne Preis +8 more
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The DEAD-box protein Dbp6 is an ATPase and RNA annealase interacting with the peptidyl transferase center (PTC) of the ribosome. [PDF]
Nucleic Acids Res, 2023 Khreiss A +8 more
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Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket [PDF]
, 2009 Katherine S. Long +5 more
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Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol. [PDF]
Nat Struct Mol Biol, 2022 Syroegin EA +5 more
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Insights into the Chloramphenicol Inhibition Effect on Peptidyl Transferase Activity, Using Two New Analogs of the Drug [PDF]
, 2011 Ourania N. Kostopoulou
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