Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates [PDF]
, 2004 Märit Pringle +3 more
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Puromycin–rRNA interaction sites at the peptidyl transferase center
RNA, 2000 The binding site of puromycin was probed chemically in the peptidyl-transferase center of ribosomes from Escherichia coli and of puromycin-hypersensitive ribosomes from the archaeon Haloferax gibbonsii. Several nucleotides of the 23S rRNAs showed altered chemical reactivities in the presence of puromycin.
Rodriguez-Fonseca, Christina +6 more
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Binding of [acetyl-14C] Trichodermin to the Peptidyl Transferase Centre of Eukaryotic Ribosomes [PDF]
, 1974 Mariano Barbacid, David Vázquez
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The mitochondrial methylation potential gates mitoribosome assembly
Nature CommunicationsS-adenosylmethionine (SAM) is the principal methyl donor in cells and is essential for mitochondrial gene expression, influencing RNA modifications, translation, and ribosome biogenesis.
Ruth I. C. Glasgow +15 more
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Recognition of Hybrid Peptidyl Carrier Proteins/Acyl Carrier Proteins in Nonribosomal Peptide Synthetase Modules by the 4′-Phophopantetheinyl Transferases AcpS and Sfp [PDF]
, 2002 Mohammad Reza Mofid +2 more
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Ribosomal Protein L27 Participates in both 50 S Subunit Assembly and the Peptidyl Transferase Reaction [PDF]
, 1998 Iwona K. Wower +2 more
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The ribosomal peptidyl transferase
, 2017 Peptide bond formation on the ribosome takes place in an active site composed of RNA. Recent progress of structural, biochemical, and computational approaches has provided a fairly detailed picture of the catalytic mechanism of the reaction. The ribosome accelerates peptide bond formation by lowering the activation entropy of the reaction due to ...
Beringer, Malte, Rodnina, Marina
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Three‐dimensional location of ribosomal protein BL2 from Bacillus stearothermophilus, a key component of the peptidyl transferase center [PDF]
, 1988 Wolfgang Hackl +2 more
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Linezolid Susceptibility And Potential Resistance Mechanisms Among Mrsa Isolated From Two Major Public Hospitals In Malaysia [PDF]
, 2014 Linezolid is the first antibiotic of a new structural class, the oxazolidinones, to be approved for clinical use in 35 years. This antimicrobial agent is broadly effective against drug-resistant gram-positive pathogens which commonly cause infections ...
Thiruchelvi , Pulingam
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Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-hydroxyl group of A2451 [PDF]
, 2005 Matthias David Erlacher
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