Results 111 to 120 of about 6,832 (204)

Presence of anti-Porphyromonas gingivalis-peptidylarginine deiminase antibodies in serum from juvenile systemic lupus erythematosus patients (Letter)

, 2018
Periodontal disease is a group of chronic inflammatory diseases affecting tooth-supporting tissues. The early stage is the presence of biofilm-associated gingival inflammation which, in patients having juvenile systemic lupus erythematosus (SLE), might ...
Sete, MR, Sztajnbok, F, Figueredo, CM, Lira, Jr R, Carlos, JC, Bostrom, EA   +5 more
core  

Peptidylarginine Deiminases: An Overview of Recent Advances in Citrullination Research

International Journal of Molecular Sciences
The peptidylarginine deiminase (PAD) family includes five isozymes (PAD1–4 and PAD6) with unique tissue distributions and substrate specificities. These enzymes facilitate citrullination, a post-translational modification where positively charged arginine residues are converted into neutral citrulline residues in the presence of calcium ions.
Magdalena Kijak-Boćkowska, Joanna Czerwińska, Agnieszka Owczarczyk-Saczonek   +2 more
openaire   +3 more sources

Peptidylarginine deiminase 4 promotes age-related organ fibrosis

, 2017
Aging promotes inflammation, a process contributing to fibrosis and decline in organ function. The release of neutrophil extracellular traps (NETs [NETosis]), orchestrated by peptidylarginine deiminase 4 (PAD4), damages organs in acute inflammatory ...
Wagner, Denisa, Cherpokova, Deya, Erpenbeck, Luise, Cifuni, Stephen M., Hayashi, Hideki, Martinod, Kimberly, Savchenko, Alexander, Mauler, Maximilian, Gallant, Maureen, Witsch, Thilo   +9 more
core   +1 more source

Ppad Carried By Omvs Exacerbated Masld Through Npas2/Cyp4a10 Pathway

International Dental Journal
Aim or purpose: This study investigated the causal link between periodontitis and metabolic dysfunction-associated steatotic liver disease (MASLD), with a specific focus on how P. gingivalis OMVs mediate hepatic lipid dysregulation through PPAD enzymatic
Yanqing Liu, Li Lin, Zhaorong Li
doaj   +1 more source

Transglutaminase and peptidylarginine deiminase in the pathogenesis of autoimmune diseases [PDF]

, 2008
Coeliac disease (CD) is becoming a model for understanding the pathogenesis of autoimmune disorders. In CD, antibodies against transglutaminase 2 (TG2) and specific glutamine residues of gliadins have been identified.
Roth, Bodil
core  

Contact with stimulated T cells up-regulates expression of peptidylarginine deiminase 2 and 4 by human monocytes

, 2012
The antigenic targets of the rheumatoid arthritis (RA)-associated autoantibodies to "citrullinated" proteins are generated following citrullination by a peptidylarginine deiminase (PAD). Of the five PAD isotypes, two - PAD2 and PAD4 - are expressed in RA
Serre, Guy, Dayer, Jean-Michel, Foulquier, Céline, Sebbag, Mireille, Chicheportiche, Rachel, Ferrari-Lacraz, Sylvie   +5 more
core   +1 more source

Peptidylarginine deiminase 4 promotes age-related organ fibrosis

, 2016
Aging promotes inflammation, a process contributing to fibrosis and decline in organ function. The release of neutrophil extracellular traps (NETs [NETosis]), orchestrated by peptidylarginine deiminase 4 (PAD4), damages organs in acute inflammatory ...
Erpenbeck, Luise, Cifuni, Stephen M., Maureen Gallant, Alexander Savchenko, Kimberly Martinod, Hayashi, Hideki, Thilo Witsch, Luise Erpenbeck, Stephen M. Cifuni, Wagner, Denisa D., Maximilian Mauler, Cherpokova, Deya, Hideki Hayashi, Martinod, Kimberly, Savchenko, Alexander, Deya Cherpokova, Denisa D. Wagner, Mauler, Maximilian, Gallant, Maureen, Witsch, Thilo   +19 more
core   +1 more source

GnRH Stimulates Peptidylarginine Deiminase Catalyzed Histone Citrullination in Gonadotrope Cells

, 2017
Peptidylarginine deiminase (PAD) enzymes convert histone tail arginine residues to citrulline resulting in chromatin decondensation. Our previous work found that PAD isoforms are expressed in female reproductive tissues in an estrous cycle-dependent ...
Muth, Aaron, Thompson, Paul R, Navratil, Amy M., Khan, Shaihla A., Cherrington, Brian D., Edwards, Brian S.   +5 more
core   +1 more source

cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type VI. [PDF]

, 2004
Peptidylarginine deiminase (PAD) catalyzes the post-translational modification of protein through the conversion of arginine to citrulline in the presence of calcium ions.
Zhang, Jiayi, Dai, Jianliang, Zeng, Li, Wang, Yu, Ying, Kang, Lin, Yun, Zheng, Huari, Mao, YuMin, Chen, Jinzhong, Xie, Yi, Li, Xin, Zhao, Enpeng   +11 more
core  

Peptidylarginine Deiminase of the Mouse

Journal of Biological Chemistry, 1989
H Takahara, M Tsuchida, M Kusubata, K Akutsu, S Tagami, K Sugawara   +5 more
openaire   +1 more source