Results 21 to 30 of about 3,645 (164)
Expression of peptidylarginine deiminase 2 and 4 in malignant mesothelioma and its clinical significance [PDF]
Jichu yixue yu linchuang, 2023 Objective To investigate the expression of peptidylarginine deiminase 2 and 4 (PAD2 and PAD4) in malignant mesothelioma (MM), their correlation with citrullinated proteins and clinical significance.
GAN Yihan, SHEN Wei, CHEN Yitong, YAN Kaili, HU Shuaiyue, JIANG Zhaoqiang, YING Shibo
doaj +1 more source
Expression of Peptidylarginine Deiminase Type 4 in Ovarian Tumors [PDF]
International Journal of Biological Sciences, 2010 Peptidylarginine deiminase type 4 (PADI4) converts arginine residues into citrulline. The current study focused on the expression of PADI4 in various subtypes of ovary cancers, and this study investigated the effects of estrogen on PADI4 expression in ...
Lin Wang, Xiaotian Chang, Guangying Yuan, Yan Zhao, Pengcheng Wang
doaj +3 more sources
Neural Regeneration Research, 2021 Peptidylarginine deiminases are a family of calcium-activated enzymes with multifaceted roles in physiological and pathological processes, including in the central nervous system.
Sigrun Lange
doaj +1 more source
The virtues and vices of protein citrullination
Royal Society Open Science, 2022 The post-translational modification of proteins expands the regulatory scope of the proteome far beyond what is achievable through genome regulation. The field of protein citrullination has seen significant progress in the last two decades.
Maria A. Christophorou
doaj +1 more source
Putative Roles for Peptidylarginine Deiminases in COVID-19 [PDF]
International Journal of Molecular Sciences, 2020 Peptidylarginine deiminases (PADs) are a family of calcium-regulated enzymes that are phylogenetically conserved and cause post-translational deimination/citrullination, contributing to protein moonlighting in health and disease. PADs are implicated in a range of inflammatory and autoimmune conditions, in the regulation of extracellular vesicle (EV ...
Elif Damla Arisan +2 more
openaire +2 more sources
Insights into peptidylarginine deiminase expression and citrullination pathways
Trends in Cell Biology, 2022 Peptidylarginine deiminases (PADs) are calcium-dependent enzymes that mediate citrullination, an irreversible post-translational modification (PTM). PAD enzymes have received increasing attention in (patho-)physiology since multi-omics analysis accelerated their expression profiling.
Yu, Karen, Proost, Paul
openaire +2 more sources
Current Challenges and Limitations in Antibody-Based Detection of Citrullinated Histones
Frontiers in Immunology, 2016 Studies on NETosis demand reliable and convenient markers to monitor the progress of this form of cell death. Because a determining step in the release of nuclear chromatin NETs requires the conversion of arginine residues to citrulline residues in ...
Indira Neeli, Marko Radic
doaj +1 more source
Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases [PDF]
International Journal of Molecular Sciences, 2020 Deimination, also known as citrullination, corresponds to the conversion of the amino acid arginine, within a peptide sequence, into the non-standard amino acid citrulline. This post-translational modification is catalyzed by a family of calcium-dependent enzymes called peptidylarginine deiminases (PADs).
Mechin, Marie-Claire +2 more
openaire +3 more sources
International Journal of Oral Science, 2021 Ulcerative Colitis (UC) has been reported to be related to Porphyromonas gingivalis (P. gingivalis). Porphyromonas gingivalis peptidylarginine deiminase (PPAD), a virulence factor released by P. gingivalis, is known to induce inflammatory responses.
Xida Zhao +10 more
doaj +1 more source
Functional role of dimerization of human peptidylarginine deiminase 4 (PAD4). [PDF]
PLoS ONE, 2011 Peptidylarginine deiminase 4 (PAD4) is a homodimeric enzyme that catalyzes Ca²⁺-dependent protein citrullination, which results in the conversion of arginine to citrulline.
Yi-Liang Liu +3 more
doaj +1 more source