Results 41 to 50 of about 6,832 (204)
Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae
Angewandte Chemie, EarlyView.The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray +4 more
wiley +2 more sources
Neutrophil extracellular traps in inflammatory disorders [PDF]
, 2014 A novel feature of polymorphonuclear granulocyte (PMN) biology is their ability to generate neutrophil extracellular traps (NETs) via a distinct process of cell death termed NETosis.
Sur Chowdhury, Chanchal
core +1 more source
Citrullination and carbamylation in the pathophysiology of rheumatoid arthritits
Frontiers in Immunology, 2015 The discovery that citrullination was crucial for the recognition of antigens by the most disease-specific class of autoantibodies in rheumatoid arthritis had a huge impact on studies aimed at understanding autoimmunity in this disease.
Ger J.M. Pruijn
doaj +1 more source
The Occurrence and Immunology of Peptidylarginine Deiminase and Its Preparation from Bovine Epidermis by an Improved Method [PDF]
, 1985 Peptidylarginine deiminase activity has been found in some tissues from at least one representative of each vertebrate class, suggesting that the ocurrence of the enzyme throughout the vertebrates is widespread.
Kubilus, Joseph, Baden, Howard P.
core +1 more source
EBioMedicine, 2021 Background: Post-translational modifications (PTMs) on proteins can be targeted by antibodies associated with autoimmunity. Despite a growing appreciation for their intrinsic role in disease, there is a lack of highly multiplexed serological assays to ...
Gabriel D. Román-Meléndez +7 more
doaj +1 more source
Novel Peptidylarginine Deiminase Type 4 (PAD4) Inhibitors. [PDF]
ACS Med Chem Lett, 2022 Provided herein are novel compounds as peptidylarginine deiminase type 4 (PAD4) inhibitors, pharmaceutical compositions, use of such compounds in treating diseases, and processes for preparing such compounds.
Sabnis RW.
europepmc +3 more sources
Peptidylarginine Deiminase Inhibitors Reduce Bacterial Membrane Vesicle Release and Sensitise Bacteria to Antibiotic Treatment [PDF]
, 2019 Outer membrane and membrane vesicles (OMV/MV) are released from bacteria and participate in cell communication, biofilm formation and host-pathogen interactions. Peptidylarginine deiminases (PADs) are phylogenetically conserved enzymes that catalyse post-
Brotherton, Dominik +19 more
core +1 more source
, 2023 Supplementary Figure 1: Correlograms representing significant correlations between plasma biomarkers based on Spearman correlation testing. Neu: neutrophil counts; MPO: myeloperoxidase; CRP: C-reactive protein; H3Cit: citrullinated histones; H3Cit-DNA ...
Peter Verhamme (831844) +5 more
core +1 more source
Life Science AllianceMast cell extracellular traps catalyzed by peptidylarginine deiminase 4 contribute to vascular stasis and nerve injury, which may contribute to acute and chronic pain in sickle cell disease.
Donovan A Argueta +10 more
doaj +1 more source
DIAGNOSTIC VALUE OF ANTI-PEPTIDYLARGININE DEIMINASE TYPE 4 (PADI-4) AND ANTI- CITRULLINATED PEPTIDE ANTIBODIES (ACCP) IN IRAQI PATIENTS WITH RHEUMATOID ARTHRITIS [PDF]
Basrah Journal of Surgery, 2014 This study aimed to examine the value of anti peptidylarginine deiminase (anti-PADI-4) antibody and anti-cyclic citrullinated peptide (anti-CCP) antibody among Iraqi patients with RA and to determine whether the activity and severity in RA patients are ...
Hassan J Hasony +1 more
doaj +1 more source