Results 61 to 70 of about 6,832 (204)
Cell Proliferation, EarlyView.This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo +5 more
wiley +1 more source
The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis
Journal of Periodontal Research, EarlyView.Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis +2 more
wiley +1 more source
, 2023 This is the full data set for the manuscript titled "Neutrophil Peptidylarginine Deiminase 4 is Essential for Detrimental Age-related Cardiac Remodeling & Dysfunction in Mice," with each tab containing the per-mouse or per-replicate data of each figure ...
Van Bruggen, Stijn, Martinod, Kim
core +1 more source
Features of the citrullinating peptidylarginine deiminase enzymes [PDF]
, 2004 Contains fulltext : 58471.pdf (Publisher’s version ) (Open Access)
Vossenaar, E.R. +10 more
openaire +3 more sources
Autoimmunity and Periodontitis
Journal of Periodontal Research, EarlyView.In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga +2 more
wiley +1 more source
The peptidylarginine deiminase gene is a conserved feature of Porphyromonas gingivalis [PDF]
Scientific Reports, 2015 AbstractPeriodontitis is an infective process that ultimately leads to destruction of the soft and hard tissues that support the teeth (the periodontium). Periodontitis has been proposed as a candidate risk factor for development of the autoimmune disease rheumatoid arthritis (RA).
Giorgio Gabarrini +9 more
openaire +2 more sources
Journal of Oral Microbiology, 2017 Porphyromonas gingivalis peptidylarginine deiminase (PPAD) is the focus of several studies due to its ability to citrullinate in vitro human proteins, which have been linked to the aetiopathogenesis of rheumatoid arthritis (RA).
Estefanía Muñoz-Atienza +5 more
doaj +1 more source
Periodontitis and Rheumatoid Arthritis—Mechanistic Evidence
Journal of Periodontal Research, EarlyView.Periodontitis and rheumatoid arthritis are linked via the two‐hit model whereby early periodontal inflammation can lead to autoantibody production capable of interacting with inflamed synovial tissues. Subsequent systemic inflammation can exacerbate the periodontal inflammatory response and bacterial dysbiosis leading to further autoantibody production
Mark Bartold +2 more
wiley +1 more source
Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus [PDF]
Journal of Clinical Investigation, 2013 Recent evidence suggests that enhanced neutrophil extracellular trap (NET) formation activates plasmacytoid dendritic cells and serves as a source of autoantigens in SLE. We propose that aberrant NET formation is also linked to organ damage and to the premature vascular disease characteristic of human SLE. Here, we demonstrate enhanced NET formation in
Knight, Jason S. +9 more
openaire +3 more sources
A continuous spectrophotometric assay method for peptidylarginine deiminase type 4 activity
, 2014 A simple, continuous spectrophotometric assay for peptidylarginine deiminase (PAD) is described. Deimination of peptidylarginine results in the formation of peptidylcitrulline and ammonia.
Liao, Y.F. +4 more
core +1 more source