Results 61 to 70 of about 3,645 (164)

The TG2/LRP1 Pathway for T Cell Activation by Post‐Translationally Modified Antigens

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Post‐translational modifications (PTMs) can generate neo‐epitopes, modified peptides that evade immune tolerance and trigger immune responses. This review focuses on the TG2/LRP1 pathway as a new paradigm for coupling the formation of post‐translationally modified peptides with their effective presentation as T‐cell antigens by dendritic cells.
Agnele Sylvia Sewa, Fu‐Chen Yang, Chaitan Khosla   +2 more
wiley   +1 more source

Citrullination and Deamidation in Type 1 Diabetes: Linking Beta Cell Stress to Neoantigen‐Driven Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Citrullination and deamidation are post‐translational modifications (PTMs) increasingly recognized as important contributors to neoepitope formation in type 1 diabetes (T1D). Under inflammatory and endoplasmic reticulum stress conditions, beta cells activate calcium‐dependent peptidylarginine deiminase and transglutaminase enzymes, leading to ...
Aïsha Callebaut, Ylke Bruggeman, Chantal Mathieu, Eddie A. James, Lut Overbergh   +4 more
wiley   +1 more source

Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus [PDF]

Journal of Clinical Investigation, 2013
Recent evidence suggests that enhanced neutrophil extracellular trap (NET) formation activates plasmacytoid dendritic cells and serves as a source of autoantigens in SLE. We propose that aberrant NET formation is also linked to organ damage and to the premature vascular disease characteristic of human SLE. Here, we demonstrate enhanced NET formation in
Knight, Jason S., Zhao, Wenpu, Luo, Wei, Subramanian, Venkataraman, O'Dell, Alexander A., Yalavarthi, Srilakshmi, Hodgin, Jeffrey B., Eitzman, Daniel T., Thompson, Paul R, Kaplan, Mariana J.   +9 more
openaire   +3 more sources

Comprehensive Evaluation of YJ‐2 as a PAD4 Inhibitor in Alleviating Ischemic Brain Injury: From NETs‐Induced Neurotoxicity to In Vivo Neuroprotection

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
The novel PAD4 inhibitor YJ‐2 potently suppresses neutrophil extracellular trap (NETs) formation. In a rat model of ischemic stroke, YJ‐2 treatment significantly reduces cerebral infarct volume and improves neurological function, demonstrating its therapeutic potential.
Yijiang Jia, Ayijiang Taledaohan, Kai Wang, Maer Maer Tuohan, Rong Chen, Liujia Chan, Haoyu Shen, Di Zhu, Yuji Wang   +8 more
wiley   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Role for Peptidylarginine Deiminase Enzymes in Disease and Female Reproduction

Journal of Reproduction and Development, 2012
The peptidylarginine deiminases (PADs) are a family of calcium-dependent enzymes that post-translationally convert positively charged arginine residues to neutrally charged citrulline in a process called citrullination. There are five PAD family members (PAD1-4 and 6), each with unique tissue distribution patterns and functional roles including ...
HORIBATA, Sachi, COONROD, Scott A., CHERRINGTON, Brian D.   +2 more
openaire   +3 more sources

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Meta-analysis of the association between PADI4 -92C/G polymorphism and rheumatoid arthritis in the Chinese population

Brazilian Journal of Medical and Biological Research, 2017
Many studies have evaluated the correlation between peptidylarginine deiminase 4 (PADI4) -92C/G polymorphism and rheumatoid arthritis (RA), but the results remain inconclusive.
Z.Y. Guo, J.X. Zhang, M. Wu, Y.F. Mei, X.J. Lin, C. Bu, Y. Xie, J. Wang   +7 more
doaj   +1 more source

Citrullinated Histone H3 as a Therapeutic Target for Endotoxic Shock in Mice

Frontiers in Immunology, 2020
Sepsis results in millions of deaths every year, with acute lung injury (ALI) being one of the leading causes of mortality in septic patients. As neutrophil extracellular traps (NETs) are abundant in sepsis, neutralizing components of NETs may be a ...
Qiufang Deng, Qiufang Deng, Baihong Pan, Baihong Pan, Hasan B. Alam, Yingjian Liang, Yingjian Liang, Zhenyu Wu, Zhenyu Wu, Baoling Liu, Nirit Mor-Vaknin, Xiuzhen Duan, Aaron M. Williams, Yuzi Tian, Yuzi Tian, Justin Zhang, Yongqing Li   +16 more
doaj   +1 more source

DNA From Neutrophil Extracellular Traps Restricts Group 3 Innate Lymphoid Cells Function in Intestinal Epithelial Repair via CCDC25

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
DNA from neutrophil extracellular traps (NET‐DNA) restricts the function of IL‐22‐dependent ILC3s in intestinal defense through coiled‐coil domain containing protein 25 (CCDC25), which hinders the repair of intestinal epithelial cells and promotes the progression of UC.
Bo Xu, Xuezhou Ke, Xueqian Xie, Qi Yi, Chunjing Li, Meng Zhao, Xiangliang Deng, Qing Wang, Hongxu Chen, Rui Xu, Shuiling Cao, Ying Zhu, Lian Zhou, Qimei Wang, Xia Luo   +14 more
wiley   +1 more source