Results 71 to 80 of about 6,832 (204)

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis [PDF]

, 2009
Antibodies to citrulline-modifi ed proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear.
Rikard Holmdahl, Bockermann, Robert, Hüseyin Uysal, Sehnert, Bettina,, Harald Burkhardt, Robert Bockermann, Bockermann, R, Nandakumar, Kutty S, Bajtner, Estelle,, Engstrom, A, Thunnissen, Marjolein M G M, Uysal, H,, Serre, Guy, Serre, G, Holmdahl, R,, Nandakumar, Kutty Selva,, Bajtner, E, Holmdahl, Rikard, Uysal, Hüseyin,, Burkhardt, Harald,, Burkhardt, H, Kutty Selva, Nandakumar,, Kutty S. Nandakumar, Bettina Sehnert, Thunnissen, MMGM, Serre, Guy,, Nandakumar, Kutty S., Burkhardt, Harald, Engström, Åke, Thunnissen, Marjolein,, Guy Serre, Engström, Åke,, Thunnissen, Marjolein M. G. M., Thunnissen, Marjolein M. G. M.,, Sehnert, B, Åke Engström, Sehnert, Bettina, Kutty Selva, Nandakumar, Nandakumar, KS, Estelle Bajtner, Lund University., Bajtner, Estelle, Thunnissen, Marjolein, Marjolein M.G.M. Thunnissen, Bockermann, Robert,, Holmdahl, Rikard,, Uysal, Hüseyin   +46 more
core   +1 more source

A Secreted Bacterial Peptidylarginine Deiminase Can Neutralize Human Innate Immune Defenses

mBio, 2018
The keystone oral pathogen Porphyromonas gingivalis is associated with severe periodontitis. Intriguingly, this bacterium is known to secrete large amounts of an enzyme that converts peptidylarginine into citrulline residues.
Tim Stobernack, Marines du Teil Espina, Lianne M. Mulder, Laura M. Palma Medina, Dillon R. Piebenga, Giorgio Gabarrini, Xin Zhao, Koen M. J. Janssen, Jarnick Hulzebos, Elisabeth Brouwer, Thomas Sura, Dörte Becher, Arie Jan van Winkelhoff, Friedrich Götz, Andreas Otto, Johanna Westra, Jan Maarten van Dijl   +16 more
doaj   +1 more source

Host and bacterial factors linking periodontitis and rheumatoid arthritis

Frontiers in Immunology, 2022
Observations from numerous clinical, epidemiological and serological studies link periodontitis with severity and progression of rheumatoid arthritis.
Anna Krutyhołowa, Karolina Strzelec, Agata Dziedzic, Grzegorz P. Bereta, Katarzyna Łazarz-Bartyzel, Jan Potempa, Jan Potempa, Katarzyna Gawron   +7 more
doaj   +1 more source

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013
Peptidylarginine deiminases are a family of enzymes that mediate post-translational modifications of protein arginine residues by deimination or demethylimination to produce citrulline. In vitro, the activity of PADs is dependent on calcium and reductive reagents carrying a free sulfhydryl group.
Shu, Wang, Yanming, Wang
openaire   +2 more sources

Metabolic reprogramming of the immune response in periodontitis

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon, Melissa Grant, Iain Chapple, Joao Paulo Steffens   +3 more
wiley   +1 more source

ABAP: Antibody-based assay for peptidylarginine deiminase activity

Analytical Biochemistry, 2007
Members of the family of peptidylarginine deiminases (PADs, EC 3.5.3.15) catalyze the posttranslational modification of peptidylarginine into peptidylcitrulline. Citrulline-containing epitopes have been shown to be major and specific targets of autoantibodies produced by rheumatoid arthritis patients. Recently, the citrullination of histone proteins by
Zendman, A.J.W., Raijmakers, R., Nijenhuis, S., Vossenaar, E.R., Tillaart, M. van den, Chirivi, R.G.S., Raats, J.M.H., Venrooij, W.J.W. van, Drijfhout, J.W., Pruijn, G.J.M.   +9 more
openaire   +4 more sources

Comparison of changes in rheumatologic conditions between the patients with high and low anti-Porphyromonas gingivalis peptidylarginine deiminase (PPAD) immunoglobulin G (IgG) titers.

, 2016
Comparison of changes in rheumatologic conditions between the patients with high and low anti-Porphyromonas gingivalis peptidylarginine deiminase (PPAD) immunoglobulin G (IgG) titers.
Tetsuo Kobayashi (807280), Ichiei Narita (156924), Akira Murasawa (152651), Satoshi Ito (12555), Atsushi Shimada (2624911), Kiyoshi Nakazono (2624908), Hiromasa Yoshie (82162), Daisuke Kobayashi (448930)   +7 more
core   +1 more source

Regulation of p53 target gene expression by peptidylarginine deiminase 4 [PDF]

, 2015
At the time of publication, Paul Thompson was not yet affiliated with UMass Medical School.Histone Arg methylation has been correlated with transcriptional activation of p53 target genes.
Li, Pingxin, Li, Ming, Luo, Yuan, Zhang, Zhiqiang, Wang, Yanming, Thompson, Paul R, Gilmour, David S., Yao, Hongjie   +7 more
core   +1 more source

Anti‐Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap‐Mediated Bone Loss in Rheumatoid Arthritis

Arthritis &Rheumatology, Volume 78, Issue 10, Page 2074-2081, October 2026.
Objective Carbamylation, a nonenzymatic post‐translational modification, contributes to rheumatoid arthritis (RA) pathogenesis. Anti‐carbamylated protein antibodies (anti‐CarP) occur in around 50% of patients with RA and associate with greater joint damage. Neutrophil extracellular traps (NETs) are a major source of carbamylated autoantigens. We sought
Shuichiro Nakabo, Norio Hanata, Eduardo Patino‐Martinez, Ronald Holewinski, Ana Barrera‐Vargas, Javier Merayo‐Chalico, Scott A. Coonrod, David A. Fox, Mariana J. Kaplan, Carmelo Carmona‐Rivera   +9 more
wiley   +1 more source