Results 71 to 80 of about 3,645 (164)
European Journal of Rheumatology, 2019 Abstract Objective: The molecular mechanism of citrullination involves the calcium-dependent peptidylarginine deiminase (PAD) family of enzymes. These enzymes induce a stereochemical modification of normal proteins and transform them into autoantigens, which in rheumatoid arthritis trigger a complex cascade of joint inflammatory events followed by ...
Martha Adriana, Badillo-Soto +7 more
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OncoImmunology, 2017 Renal insufficiency is a frequent cancer-associated problem affecting more than half of all cancer patients at the time of diagnosis. To minimize nephrotoxic effects the dosage of anticancer drugs are reduced in these patients, leading to sub-optimal ...
Jessica Cedervall +8 more
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BMC Veterinary Research, 2018 Background Canine neutrophils release neutrophil extracellular traps (NETs) in response to lipopolysaccharide but NETs from clinical septic dogs had not been identified.
Ronald H. L. Li +3 more
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Frontiers in ImmunologyThe role of neutrophils in host defense involves several cell processes including phagocytosis, degranulation of antimicrobial proteins, and the release of neutrophil extracellular traps (NETs).
Rory Baird +8 more
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Biochemistry Research International, 2012 The peptidylarginine deiminases (PADs) are a family of posttranslational modification enzymes that catalyze the conversion of positively charged protein-bound arginine and methylarginine residues to the uncharged, nonstandard amino acid citrulline.
Sunish Mohanan +5 more
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Frontiers in ImmunologyObesity-driven type 2 diabetes mellitus is sustained by chronic low-grade sterile inflammation. The intercellular mechanisms underlying this self-amplifying state remain incompletely defined. Extracellular vesicles and neutrophil extracellular traps have
He Gao +8 more
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Role of peptidylarginine deiminase type 4 in gastric cancer
Experimental and Therapeutic Medicine, 2016 Peptidylarginine deiminase type 4 (PADI4) post-translationally converts peptidylarginine to citrulline, appearing to be overexpressed in numerous carcinomas. The current study aimed to investigate the expression of PADI4 in gastric cancer tissues and its effect on the biological activities of SGC-7901 and AGS tumor cell lines.
Xin, Jiang, Song, Xiuqi
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Activities and properties of peptidylarginine deiminases of several vertebrate brains.
Agricultural and Biological Chemistry, 1986 Extracts from brains of mouse, rat, rabbit, pig, chicken, and duck were assayed for peptidylarginine deiminase, which catalyzes the deimination of arginyl residues. There was peptidylarginine deiminase in the extracts from all the brains that we tested, suggesting the widespread occurrence of this enzyme in vertebrate brains. The levels of the activity
TAKAHARA, Hidenari +2 more
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iScienceSummary: SARS-CoV-2, the causative agent of COVID-19, remains a global concern due to gaps in understanding its pathogenesis. Peptidyl-arginine deiminases (PADs) are emerging as key regulators of viral replication and inflammation.
Selina Pasquero +20 more
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Protein Unfolding by Peptidylarginine Deiminase [PDF]
Journal of Biological Chemistry, 1996 Edit Tarcsa +5 more
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