Results 51 to 60 of about 3,645 (164)

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Features of the citrullinating peptidylarginine deiminase enzymes [PDF]

, 2004
Contains fulltext : 58471.pdf (Publisher’s version ) (Open Access)
Vossenaar, ER, Zendman, AJW, Raijmakers, R, Welting, TJ, Heijden, A van der, Horstman, WAM, Vogelzangs, JH, Nijenhuis, S, Venrooij, WJ van, Pruijn, GJM   +9 more
openaire   +3 more sources

A Secreted Bacterial Peptidylarginine Deiminase Can Neutralize Human Innate Immune Defenses

mBio, 2018
The keystone oral pathogen Porphyromonas gingivalis is associated with severe periodontitis. Intriguingly, this bacterium is known to secrete large amounts of an enzyme that converts peptidylarginine into citrulline residues.
Tim Stobernack, Marines du Teil Espina, Lianne M. Mulder, Laura M. Palma Medina, Dillon R. Piebenga, Giorgio Gabarrini, Xin Zhao, Koen M. J. Janssen, Jarnick Hulzebos, Elisabeth Brouwer, Thomas Sura, Dörte Becher, Arie Jan van Winkelhoff, Friedrich Götz, Andreas Otto, Johanna Westra, Jan Maarten van Dijl   +16 more
doaj   +1 more source

Neutrophil‐based immunotherapy: A metabolic lens on mechanisms and therapeutic implications

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
TAN metabolic reprogramming critically contributes to tumour immune evasion. A 4‑Tier TAN‑MetaC classification framework is proposed, along with an overview of translational opportunities and bottlenecks for TAN metabolism‑targeted immunotherapies. Abstract Background Tumor‐associated neutrophils (TANs) serve as pivotal immune modulators in the tumor ...
Wenchao Xu, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +4 more
wiley   +1 more source

The peptidylarginine deiminase gene is a conserved feature of Porphyromonas gingivalis [PDF]

Scientific Reports, 2015
AbstractPeriodontitis is an infective process that ultimately leads to destruction of the soft and hard tissues that support the teeth (the periodontium). Periodontitis has been proposed as a candidate risk factor for development of the autoimmune disease rheumatoid arthritis (RA).
Giorgio Gabarrini, Menke de Smit, Johanna Westra, Elisabeth Brouwer, Arjan Vissink, Kai Zhou, John W. A. Rossen, Tim Stobernack, Jan Maarten van Dijl, Arie Jan van Winkelhoff   +9 more
openaire   +2 more sources

The Impact of Oral‐Gut Microbiota Structure and Its Manipulation on RA Development and Management

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
(A) Schematic representation of oral–gut microbiota composition in health and rheumatoid arthritis (RA), highlighting the enrichment of beneficial microorganisms (green) under healthy conditions and the expansion of pathogenic microorganisms (orange) in RA‐associated dysbiosis.
Parisa Ahmadi, Mahmoud Mahmoudi, Sina Mozaffari‐Jovin, Ramiar Kamal Kheder, Tola Abdulsattar Faraj, Samaneh Mollazadeh, Jafar Hajavi, Hanieh Kolahdooz, Seyed‐Alireza Esmaeili   +8 more
wiley   +1 more source

Neutrophil extracellular traps induced by activated platelets as a cause of neutrophil–platelet aggregation in β‐thalassaemia/haemoglobin E patients

British Journal of Haematology, Volume 209, Issue 2, Page 703-717, August 2026.
Abnormal neutrophils and platelets in splenectomised β‐thalassaemia/haemoglobin E (HbE) disease contribute to neutrophil–platelet aggregation, leading to a high risk of thrombus formation. Activated platelets induce neutrophils to generate neutrophil extracellular trap (NETs) via the P‐selectin–P‐selectin glycoprotein ligand‐1 (PSGL1) pathway, which ...
Rattanawan Thubthed, Rattanaporn Praneetponkang, Potchaman Sittipaisankul, Chayada Thiengtavor, Suwathida Chumpuchanaphai, Kittiphong Paiboonsukwong, Suthat Fucharoen, Kovit Pattanapanyasat, Jim Vadolas, Duncan R. Smith, Saovaros Svasti, Pornthip Chaichompoo   +11 more
wiley   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha, Holly M. Weisfelder, Thanh D. Do   +2 more
wiley   +1 more source

ABAP: Antibody-based assay for peptidylarginine deiminase activity

Analytical Biochemistry, 2007
Members of the family of peptidylarginine deiminases (PADs, EC 3.5.3.15) catalyze the posttranslational modification of peptidylarginine into peptidylcitrulline. Citrulline-containing epitopes have been shown to be major and specific targets of autoantibodies produced by rheumatoid arthritis patients. Recently, the citrullination of histone proteins by
Zendman, A.J.W., Raijmakers, R., Nijenhuis, S., Vossenaar, E.R., Tillaart, M. van den, Chirivi, R.G.S., Raats, J.M.H., Venrooij, W.J.W. van, Drijfhout, J.W., Pruijn, G.J.M.   +9 more
openaire   +4 more sources