Results 51 to 60 of about 6,832 (204)

Citrullination Licenses Calpain to Decondense Nuclei in Neutrophil Extracellular Trap Formation

Frontiers in Immunology, 2019
Neutrophils respond to various stimuli by decondensing and releasing nuclear chromatin characterized by citrullinated histones as neutrophil extracellular traps (NETs).
Stefanie Gößwein, Aylin Lindemann, Aparna Mahajan, Christian Maueröder, Eva Martini, Jay Patankar, Georg Schett, Christoph Becker, Stefan Wirtz, Nora Naumann-Bartsch, Marco E. Bianchi, Peter A. Greer, Günter Lochnit, Martin Herrmann, Markus F. Neurath, Moritz Leppkes   +15 more
doaj   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis.

, 2015
At the time of publication, Paul Thompson was not yet affiliated with UMass Medical School.RATIONALE: Neutrophil extracellular trap (NET) formation promotes vascular damage, thrombosis, and activation of interferon-alpha-producing plasmacytoid dendritic ...
Zhao, Wenpu, O'Dell, Alexander A., Subramanian, Venkataraman, Grenn, Robert C., Kaplan, Mariana J., Thompson, Paul R, Guo, Chiao, Luo, Wei, Knight, Jason S., Yalavarthi, Srilakshmi, Eitzman, Daniel T.   +10 more
core   +1 more source

Replication Data for: Peptidylarginine deiminase 4 and ADAMTS13 activity in Staphylococcus aureus bacteremia

, 2023
This is the full data set for the manuscript titled "Peptidylarginine deiminase 4 and ADAMTS13 activity in Staphylococcus aureus bacteremia." Dataset contains the raw data and outliers for the study (indicated in red font).
Martens, Caroline, Martinod, Kim
core   +1 more source

Peptidylarginine Deiminase and Citrullination: Potential Therapeutic Targets for Inflammatory Diseases [PDF]

, 2013
The multiple post-translational modifications of proteins display specific gain- or loss-of-function under normal and abnormal conditions. These modifications are precisely regulated by post-translational modification enzymes.
장병기, 신성재
core   +1 more source

Neutrophil Extracellular Traps Exacerbate Secondary Injury via Promoting Neuroinflammation and Blood–Spinal Cord Barrier Disruption in Spinal Cord Injury

Frontiers in Immunology, 2021
As the first inflammatory cell recruited to the site of spinal cord injury (SCI), neutrophils were reported to be detrimental to SCI. However, the precise mechanisms as to how neutrophils exacerbate SCI remain largely obscure.
Zhou Feng, Lingxia Min, Liang Liang, Beike Chen, Hui Chen, Yi Zhou, Weiwei Deng, Hongliang Liu, Jingming Hou   +8 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Effect of enzymatic deimination on the conformation of recombinant prion protein [PDF]

, 2009
Deimination is the post-translational conversion of arginine residues to citrulline. It has been implicated as a causative factor in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis and more recently, as a marker of ...
Oxley, David, Meersman, Filip, Webster, Judith, Young, Duncan S., Dear, Denise V., Bronstein, Igor, Gill, Andy   +6 more
core  

Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration

BMC Cancer, 2017
Background Penetration of the mammary gland basement membrane by cancer cells is a crucial first step in tumor invasion. Using a mouse model of ductal carcinoma in situ, we previously found that inhibition of peptidylarginine deiminase 2 (PAD2, aka PADI2)
Sachi Horibata, Katherine E. Rogers, David Sadegh, Lynne J. Anguish, John L. McElwee, Pragya Shah, Paul R. Thompson, Scott A. Coonrod   +7 more
doaj   +1 more source

NETosis in the Kidney, Liver, and Lung of Mice With Cecal Ligation and Puncture‐Induced Sepsis and the Ameliorating Effects of Adipose‐Derived Stem Cell Exosomes

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐induced organ failure involves dysregulated neutrophil responses, including neutrophil extracellular trap (NET) formation, via NETosis. Exosomes generated from adipose‐derived stem cells (ADSCs) have shown potential in sepsis treatment. This study characterized organ‐specific NETosis in the kidney, liver, and lungs using a murine cecal ...
Shao‐Chun Wu, Tsu‐Hsiang Lu, Yi‐Chan Wu, Chia‐Wei Lin, Chia‐Wen Tsai, Ching‐Hua Hsieh   +5 more
wiley   +1 more source