Results 31 to 40 of about 3,645 (164)

PADs and NETs in digestive system: From physiology to pathology

Frontiers in Immunology, 2023
Peptidylarginine deiminases (PADs) are the only enzyme class known to deiminate arginine residues into citrulline in proteins, a process known as citrullination. This is an important post-translational modification that functions in several physiological
Yi-Hang Song, Zhi-Jie Wang, Le Kang, Zi-Xuan He, Sheng-Bing Zhao, Xue Fang, Zhao-Shen Li, Shu-Ling Wang, Yu Bai   +8 more
doaj   +1 more source

Peptidylarginine deiminases and deiminated proteins at the epidermal barrier [PDF]

Experimental Dermatology, 2018
AbstractDeimination or citrullination is a post‐translational modification catalysed by a family of calcium‐dependent enzymes called peptidylarginine deiminases (PADs). It corresponds to the transformation of arginine residues within a peptide sequence into citrulline residues. Deimination induces a decreased net charge of targeted proteins; therefore,
Cau, Laura, Méchin, Marie-Claire, Simon, Michel   +2 more
openaire   +2 more sources

Citrullination and carbamylation in the pathophysiology of rheumatoid arthritits

Frontiers in Immunology, 2015
The discovery that citrullination was crucial for the recognition of antigens by the most disease-specific class of autoantibodies in rheumatoid arthritis had a huge impact on studies aimed at understanding autoimmunity in this disease.
Ger J.M. Pruijn
doaj   +1 more source

Citrullination of a phage-displayed human peptidome library reveals the fine specificities of rheumatoid arthritis-associated autoantibodies

EBioMedicine, 2021
Background: Post-translational modifications (PTMs) on proteins can be targeted by antibodies associated with autoimmunity. Despite a growing appreciation for their intrinsic role in disease, there is a lack of highly multiplexed serological assays to ...
Gabriel D. Román-Meléndez, Daniel R. Monaco, Janelle M. Montagne, Rachel S. Quizon, Maximilian F. Konig, Mekbib Astatke, Erika Darrah, H. Benjamin Larman   +7 more
doaj   +1 more source

Candida albicans-Induced NETosis Is Independent of Peptidylarginine Deiminase 4

Frontiers in Immunology, 2018
Neutrophils are the most abundant innate immune cells and the first line of defense against many pathogenic microbes, including the human fungal pathogen Candida albicans.
Eva Guiducci, Christina Lemberg, Noëmi Küng, Elisabeth Schraner, Alexandre P. A. Theocharides, Salomé LeibundGut-Landmann   +5 more
doaj   +1 more source

DIAGNOSTIC VALUE OF ANTI-PEPTIDYLARGININE DEIMINASE TYPE 4 (PADI-4) AND ANTI- CITRULLINATED PEPTIDE ANTIBODIES (ACCP) IN IRAQI PATIENTS WITH RHEUMATOID ARTHRITIS [PDF]

Basrah Journal of Surgery, 2014
This study aimed to examine the value of anti peptidylarginine deiminase (anti-PADI-4) antibody and anti-cyclic citrullinated peptide (anti-CCP) antibody among Iraqi patients with RA and to determine whether the activity and severity in RA patients are ...
Hassan J Hasony, Hisham Abd-AlJalel Badran   +1 more
doaj   +1 more source

Mast cell extracellular trap formation underlies vascular and neural injury and hyperalgesia in sickle cell disease

Life Science Alliance
Mast cell extracellular traps catalyzed by peptidylarginine deiminase 4 contribute to vascular stasis and nerve injury, which may contribute to acute and chronic pain in sickle cell disease.
Donovan A Argueta, Huy Tran, Yugal Goel, Aithanh Nguyen, Julia Nguyen, Stacy B Kiven, Chunsheng Chen, Fuad Abdulla, Gregory M Vercellotti, John D Belcher, Kalpna Gupta   +10 more
doaj   +1 more source

Citrullination Licenses Calpain to Decondense Nuclei in Neutrophil Extracellular Trap Formation

Frontiers in Immunology, 2019
Neutrophils respond to various stimuli by decondensing and releasing nuclear chromatin characterized by citrullinated histones as neutrophil extracellular traps (NETs).
Stefanie Gößwein, Aylin Lindemann, Aparna Mahajan, Christian Maueröder, Eva Martini, Jay Patankar, Georg Schett, Christoph Becker, Stefan Wirtz, Nora Naumann-Bartsch, Marco E. Bianchi, Peter A. Greer, Günter Lochnit, Martin Herrmann, Markus F. Neurath, Moritz Leppkes   +15 more
doaj   +1 more source

Microbiome and aging: Trajectories of microbiome age across human ecosystems and their systemic effects

iMeta, EarlyView.
Microbiome age (MA) has emerged as an innovative biomarker of biological aging, reflecting host aging trajectories through dynamic alterations in microbial composition, function, and host–microbe interactions across multiple body ecosystems. Diverse computational strategies—including traditional machine learning, deep learning, and multi‐omics ...
Zhexin Ni, Jiaojiao Xie, Zhichun Zhang, Keming Zhang, Jie Ding, Mingyang Chang, Ying Su, Yunan Zhang, Mingfei Yao, Chengyuan Wang, Yan Yan, Wenjie Fang, Hainv Gao, Xuecong Tian, Yangshuo Li, Xinlin Zhu, Wen Zhang, Wanqing Liao, Gaoyuan Xu, Guojing Chen, Xiaoyi Lv, Chaoqin Yu, Weihua Pan, Vadim Molodtsov, Lanjuan Li, Yue Gao, Wei Zhou   +26 more
wiley   +1 more source

Breast Cancer‐Derived AZU1 Educates Neutrophils to Promote Tumor Progression and Metastasis Through PAD4‐Dependent Extracellular Trap Formation

Molecular Carcinogenesis, EarlyView.
ABSTRACT Neutrophil extracellular traps (NETs) play crucial roles in cancer progression, but their regulatory mechanisms in breast cancer remain poorly understood. We developed a NETs‐related prognostic risk model using TCGA breast cancer data and identified key biomarkers through bioinformatics analysis.
Zhen Huang, Zhe Wu, Guiyue Zhu, Fangyu Qiu, Lihui Li, Yujie Xie, Chunyu Wei, Yinhua Pan, Quanqing Zou, Yuntian Tang   +9 more
wiley   +1 more source