Results 81 to 90 of about 11,623 (233)

Cyclophilin D in Mitochondrial Dysfunction: A Key Player in Neurodegeneration?

Biomolecules, 2023
Mitochondrial dysfunction plays a pivotal role in numerous complex diseases. Understanding the molecular mechanisms by which the “powerhouse of the cell” turns into the “factory of death” is an exciting yet challenging task that can unveil new ...
Gabriele Coluccino, Valentina Pia Muraca, Alessandra Corazza, Giovanna Lippe   +3 more
doaj   +1 more source

An optimised system for refolding of human glucose 6-phosphate dehydrogenase [PDF]

, 2009
Background Human glucose 6-phosphate dehydrogenase (G6PD), active in both dimer and tetramer forms, is the key entry enzyme in the pentose phosphate pathway (PPP), providing NADPH for biosynthesis and various other purposes, including protection against ...
Xiao-Tao Wang, Paul C Engel
core   +2 more sources

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source

The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor α in breast cancer.

PLoS ONE, 2013
In hormone receptor-positive breast cancers, most tumors in the early stages of development depend on the activity of the estrogen receptor and its ligand, estradiol. Anti-estrogens, such as tamoxifen, have been used as the first line of therapy for over
Chiara Lucchetti, Isabella Caligiuri, Giuseppe Toffoli, Antonio Giordano, Flavio Rizzolio   +4 more
doaj   +1 more source

Die Funktion des Responseregulators ARR2 in der Entwicklung von Arabidopsis thaliana [PDF]

, 2004
In dieser Arbeit konnte mittels physiologischer Experimente, Expressionsanalysen, Phosphorylierungsassays und Transaktivierungsanalysen eine komplexe Funktion von ARR2 in verschiedenen Signaltransduktionswegen von Arabidopsis aufgedeckt werden.
Haß, Claudia
core  

Network analysis of quantitative proteomics on asthmatic bronchi: effects of inhaled glucocorticoid treatment [PDF]

, 2011
Background Proteomic studies of respiratory disorders have the potential to identify protein biomarkers for diagnosis and disease monitoring. Utilisation of sensitive quantitative proteomic methods creates opportunities to determine individual patient ...
Serena E O'Neil, Brigita Sitkauskiene, Agne Babusyte, Algirda Krisiukeniene, Kristina Stravinskaite-Bieksiene, Raimundas Sakalauskas, Carina Sihlbom, Linda Ekerljung, Elisabet Carlsohn, Jan Lötvall   +9 more
core   +1 more source

Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities [PDF]

Biomolecules, 2017
Analyses of sequences and structures of the cyclosporine A (CsA)-binding proteins (cyclophilins) and the immunosuppressive macrolide FK506-binding proteins (FKBPs) have revealed that they exhibit peculiar spatial distributions of charges, their overall hydrophobicity indexes vary within a considerable level whereas their points isoelectric (pIs) are ...
openaire   +3 more sources

CypA Mediates Non‐Small Cell Lung Cancer Chemoresistance by Attenuating Ferroptosis via Stabilizing SLC7A11

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Summary diagram for the role of CypA in chemoresistance in non‐small cell lung cancer (NSCLC). CypA is overexpressed in chemoresistance NSCLC and drives therapeutic evasion by competitively binding to the K37 site of SLC7A11, thereby blocking TRIM3 mediated K11‐linked ubiquitination and proteasomal degradation, ultimately inhibiting lipid peroxidation ...
Zhongcheng Wang, An Li, Ziwei Song, Xiangming Liu, Yong Ge, Zhiqiao Chen, Yuhui Liu, Boyu Zhang, Hao Zhang, Ting Lan   +9 more
wiley   +1 more source

Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons. [PDF]

PLoS ONE, 2008
Mutations in ATCAY that encodes the brain-specific protein BNIP-H (or Caytaxin) lead to Cayman cerebellar ataxia. BNIP-H binds to glutaminase, a neurotransmitter-producing enzyme, and affects its activity and intracellular localization.
Jan Paul Buschdorf, Li Li Chew, Unice Jim Kim Soh, Yih-Cherng Liou, Boon Chuan Low   +4 more
doaj   +1 more source

Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis [PDF]

, 2015
The mitochondrial permeability transition pore is a recognized drug target for neurodegenerative conditions such as multiple sclerosis and for ischemia-reperfusion injury in the brain and heart.
Al-Izki, Al-Izki, Alavian, Allen, Amor, Astin, Bainbridge, Baines, Baker, Barbarino, Barrientos, Bart, Basso, Bonora, Campbell, Chinopoulos, Chung, Coles, Compston, Davis, Davis, Du, Dube, Dutta, Emsley, Forte, Gaali, Gallay, Gane, Giorgio, Giorgio, Gogarten, Guo, Halestrap, Hampton, Hazelton, Hecking, Hogan, Hoye, Hånell, Jackson, Jackson, Kageyama, Kajitani, Kapoor, Kappos, Kato, Kutzelnigg, Laskowski, Lemasters, Leo, Lim, Liu, Macarrón, Mahad, Malouitre, Marta, Martin, Martin, Mbye, McCoy, McEwan, Millard, Murshudov, Nakagawa, Naldini, Nikolovska-Coleska, O'Neill, Ohno, Porteous, Pryce, Pryce, Quintanilla, Raftopoulos, Rasaiyaah, Readnower, Reddy, Reily, Rodrigues, Ross, Savino, Scheinberg, Schinkel, Schlatter, Schüttelkopf, Sharma, Smulik, Starr, Su, Su, Templeton, Trapp, Vagin, Valasani, Winn, Wu, Ylinen, Zufferey   +97 more
core   +3 more sources