Results 131 to 140 of about 1,730 (178)
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Recent advances in anticancer peptoids
Bioorganic Chemistry, 2023Since most tumors become resistant to drugs in a gradual and irreversible manner, making treatment less effective over time, anticancer drugs require continuous development. Peptoids are a class of peptidomimetics that can be easily synthesized and optimized.
Jidan, Zhu +5 more
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The pH Response of a Peptoid Oligomer
The Journal of Physical Chemistry B, 2023Polypeptoids are N-substituted glycine polymers, which differ from peptides in the placement of the side chain on the amide nitrogen rather than the Cα carbon. A peptoid with a chiral side chain containing both an aromatic group and carboxylic acid has a structure that responds to pH changes.
In Chul Hwang, Steven W. Rick
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Amide bond hydrolysis of peptoids
Chemical Communications, 2022A chiral non-coordinating substitution at N-terminal end within peptoids facilitates regio-selective amide bond hydrolysis mediated by a transition metal ion and/or an acidic buffer as evident by X-ray crystallographic analysis, supported by ESI-MS.
Pritam Ghosh +3 more
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Synthesis of Antimicrobial Peptoids
2013Peptoids (N-substituted glycines) are mimics of α-peptides in which the side chains are attached to the backbone N (α) -amide nitrogen instead of the C (α) -atom. Peptoids hold promise as therapeutics since they often retain the biological activity of the parent peptide and are stable to proteases.
Hansen, Paul Robert, Munk, Jens
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Peptoids and Peptide–Peptoid Hybrid Biopolymers as Peptidomimetics
2013Peptoids (oligomers of N-substituted glycine residues) and peptide-peptoid hybrid polymers (peptomers) are interesting classes of compounds mimicking structure and function of biologically active peptides. The oligomeric peptidomimetics such as peptoids are particularly important compounds since they provide access to an enormous molecular diversity ...
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Biopolymers, 2019
AbstractA review of molecular tools and sensors assembled onN‐substituted glycine, or α‐peptoid, oligomers between 2013 and November 2018 with the following sections: (a) Peptoids as crystal growth modifiers, (b) Peptoids as catalysts, (c) Ion and molecule sequestration and transport, (d) Peptoid sensors, (e) Macromolecule recognition, (f) Cellular ...
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AbstractA review of molecular tools and sensors assembled onN‐substituted glycine, or α‐peptoid, oligomers between 2013 and November 2018 with the following sections: (a) Peptoids as crystal growth modifiers, (b) Peptoids as catalysts, (c) Ion and molecule sequestration and transport, (d) Peptoid sensors, (e) Macromolecule recognition, (f) Cellular ...
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Porphyrin–Peptoid Conjugates: Face-to-Face Display of Porphyrins on Peptoid Helices
Organic Letters, 2013Distance, orientation, and number controlled porphyrin-peptoid conjugates (PPCs) were efficiently synthesized. Cofacial (1, 2, and 4), slipped-cofacial (3), and unstructured (5) arrangements of porphyrins provided distinct optical and electronic properties characterized by UV-vis and circular dichroism spectroscopy.
Boyeong, Kang +4 more
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A fluorescent peptoid pH‐sensor
Peptide Science, 2013ABSTRACTPeptoids, N‐substituted glycine oligomers, can adopt stable three‐dimensional structures and have found diverse application as peptide surrogates and as nanomaterials. In this report, we have expanded peptoid function to include pH sensing by coupling pH‐induced peptoid conformational changes with fluorescence intensity changes.
Amelia A, Fuller +2 more
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A Peptoid with Extended Shape in Water
Journal of the American Chemical Society, 2019The term "peptoids" was introduced decades ago to describe peptide analogues that exhibit better physicochemical and pharmacokinetic properties than peptides. Oligo(N-substituted glycine) (oligo-NSG) was previously proposed as a peptoid due to its high proteolytic resistance and membrane permeability.
Jumpei Morimoto +10 more
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Synthesis of nucleobase-functionalized β-peptoids and β-peptoid hybrids
Tetrahedron Letters, 2006Abstract The solid-phase synthesis of a new class of nucleobase-modified peptide-mimetic oligomers is described. β-Peptoids and β-peptoid hybrids bearing thymine on the side chain are prepared from N-Fmoc-N-[2-(thymin-1-yl)ethyl]-β-alanine.
Eduard Bardají +2 more
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