Results 91 to 100 of about 65,936,322 (300)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Analysis of Cattle Husbandry and Farming Systems Changes in an Algerian Sylvopastoral Area

open access: yesRevue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2002
This study analyzed the cattle husbandry role in livestock systems and farms in a forested area of Northeastern Algeria. The study area was a representative sample of Algeria 500,000 ha of cork oak (Quercus suber) forests. It is the wettest region of the
T. Madani   +3 more
doaj   +1 more source

Les performances de reproduction en élevage laitier

open access: yes, 2000
Le suivi des performances de reproduction mis en place par le Cirad, l'Ede, le Groupement technique vétérinaire et le Syndicat des vétérinaires praticiens depuis 1988 dans les élevages laitiers de la Réunion a permis d'établir un référentiel sur la reproduction des vaches laitières. L'outil de suivi informatique est opérationnel depuis 1994.
Tillard, Emmanuel   +4 more
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Le mouton Djallonké à Kolokopé (Togo) : paramètres de reproduction des brebis et viabilité des agneaux

open access: yesRevue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1998
Ce travail qui avait pour objet d'étudier les performances de reproduction des brebis et la viabilité des agneaux Djallonké au Centre d'appui technique de Kolokopé (Togo) a porté sur 163 brebis et 4 503 agneaux.
A. Missohou   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Taux d'alimentation pendant la gamétogenèse et performance de reproduction chez la truite fario

open access: yesKnowledge and Management of Aquatic Ecosystems, 1980
Des truites fario (Salmo trutta fario) mâles et femelles ont été soumises entre mars et septembre à des régimes alimentaires à base de granulés, à des taux quotidiens de 0,4.
BILLARD R., DE FREMONT M.
doaj   +1 more source

Management of Reproduction in Dairy Herds with Natural Service or Timed Artificial Insemination

open access: yesEDIS, 2011
Both natural service and artificial insemination programs can work for managing reproduction on dairy farms. This 3-page fact sheet provides comparison of reproductive performance and economic considerations. Written by Fábio S.
Fábio S. Lima   +3 more
doaj   +1 more source

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