Results 101 to 110 of about 73,546 (303)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finalités et aspects méthodologiques d'un système informatisé de suivi individuel des animaux dans les élevages bovins villageois du Nord de la Côte d'Ivoire

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1981
Après avoir brièvement décrit le fonctionnement traditionnel des parcs villageois du Nord-ivoirien et la vocation de cet élevage bovin, les auteurs présentent les grandes lignes du programme de recherches mis en place dans ce cadre, en vue de la ...
Jean-Paul Poivey, J.L. Seitz, Etienne Landais   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Photoperiod, metabolism and reproduction: ad vantage of the equine model [PDF]

, 2010
Equidae are born in the spring. This is due to the fact that mares go through a period of anovulation from October to the end of April. For breeders, bringing forward the first ovulation presents an enormous advantage, as it increases ...
Philippe Chemineau, Jean-Baptiste Menassol, MENASSOL, Jean-Bapriste, GUILLAUME, Daniel, CHEMINEAU, Philippe, MALPAUX, Benoît, Menassol, Jean-Baptiste, SALAZAR-ORTIZ, Juan, Daniel Guillaume, Juan Salazar-Ortiz, Benoît Malpaux   +10 more
core   +1 more source

Intérêt d'un traitement antiparasitaire contre les strongles et les coccidies à l'agnelage de la brebis Djallonké

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1996
Trois lots de 14 brebis Djallonké ont été comparés : l'un (lot E) avec un traitement antiparasitaire à la mise bas avec de l'Ivomec® ou du Valbazen® et de l'Amprol®, l'autre (lot T2) avec trois traitements antiparasitaires classiques avec les mêmes ...
Sylvie Hounzangbe-Adote, Christian Meyer
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Le mouton Djalonké de Côte-Ivoire en milieu villageois, comportement et alimentation

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1976
Le comportement du mouton à poil ras des zones tropicales humides est fort peu connu. Son élevage se heurte à de nombreuses difficultés. En plus des maladies diverses, il semble bien que la dégénérescence, les saillies et gestations précoces, la ...
D. Rombaut, Guy Van Vlaenderen
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Modelagem de terreno utilizando sistemas fotogramétricos [PDF]

, 2002
Tese (doutorado) - Universidade Federal de Santa catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção.O processo tecnológico, associado a engenharia torna-se cada dia mais avançado.
Oliveira, Francisco Henrique de
core