Results 111 to 120 of about 73,546 (303)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Sensibilité de la reproduction des vaches allaitantes à la dynamique des lipides corporels : une approche par modélisation

, 2014
Les systèmes bovins allaitants reposent sur une va lorisation optimale des ressources herbagères. Les contextes économique et climatique actuels augmentent le risque de pé riodes de sous-alimentation pouvant intervenir à n’importe quel moment du c ycle ...
Friggens, Nicolas Charles, Recoules, Emilie, Martin, Olivier, De La Torre Capitan, Anne, Agabriel, Jacques, Blanc, Fabienne, Friggens, Nicolas,   +6 more
core   +1 more source

Examen de l’aptitude à la reproduction chez le bélier et le bouc

Revue Marocaine des Sciences Agronomiques et Vétérinaires, 2018
L’examen de l’aptitude à la reproduction (EAR) du mâle est une composante importante de l’élevage des petits ruminants. L’EAR est mieux réalisée 2 mois avant la saison de reproduction.
A. TIBARY, R. BOUKHLIQ, K. EL ALLALI
doaj  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Impact économique du suivi de reproduction en élevage bovin laitier : étude dans une clientèle des Ardennes

, 2020
The offer on reproductive herd health program has been growing up for several years in dairy herds. It is a global approach with regular visits to improve reproductive performance.
Ledoux, Eva
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Performance, carcass and meat quality in pigs [PDF]

, 2004
In this thesis, influences of conventional and organic rearing systems, breed crosses and feeding regimens on performance, carcass and technological and sensory meat quality traits in pigs were investigated.
Heyer, Anke
core  

Performances de reproduction de l'élevage canin en France

, 2015
Les données enregistrées par 5667 éleveurs dans un logiciel privé sur 46393 périodes de chaleur de 27221 chiennes de 248 races et 204537 chiots ont permis de décrire les performances de l'élevage canin français. Le taux de gestation par cycle était de 87,8%, 6,8% des chiennes gravides ont avorté.
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source