Results 111 to 120 of about 1,025,819 (311)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Taux d'alimentation pendant la gamétogenèse et performance de reproduction chez la truite fario

Knowledge and Management of Aquatic Ecosystems, 1980
Des truites fario (Salmo trutta fario) mâles et femelles ont été soumises entre mars et septembre à des régimes alimentaires à base de granulés, à des taux quotidiens de 0,4.
BILLARD R., DE FREMONT M.
doaj   +1 more source

The effect of strategic supplementation with trans-10,cis-12 conjugated linoleic acid on the milk production, estrous cycle characteristics, and reproductive performance of lactating dairy cattle [PDF]

, 2012
Peer-reviewedThis is the author’s version of a work that was accepted for publication in Journal of Dairy Science. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control ...
Butler, Stephen, Dewhurst, Richard J., Evans, A.C.O., Hennessy, Alan A., Hutchinson, Ian A., Lonergan, P.   +5 more
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Non-equivalence of anti-Müllerian hormone automated assays—clinical implications for use as a companion diagnostic for individualised gonadotrophin dosing [PDF]

, 2017
STUDY QUESTION Can anti-Müllerian hormone (AMH) automated immunoassays (Elecsys® and Access) be used interchangeably as a companion diagnostic for individualisation of follitropin delta dosing?
Dewailly, Didier, Fairburn, Craig, Fanchin, Renato, Fleming, Richard, Hung Yu Ng, Ernest, Iliodromiti, Stamatina, Li, Hang Wun Raymond, Lukaszuk, Krzysztof, Nelson, Scott M., Pigny, Pascal, Salje, Barbara, Tadros, Teddy, van Helden, Joseph, Weiskirchen, Ralf   +13 more
core   +2 more sources

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Intérêt d'un traitement antiparasitaire contre les strongles et les coccidies à l'agnelage de la brebis Djallonké

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1996
Trois lots de 14 brebis Djallonké ont été comparés : l'un (lot E) avec un traitement antiparasitaire à la mise bas avec de l'Ivomec® ou du Valbazen® et de l'Amprol®, l'autre (lot T2) avec trois traitements antiparasitaires classiques avec les mêmes ...
Sylvie Hounzangbe-Adote, Christian Meyer
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Le mouton Djalonké de Côte-Ivoire en milieu villageois, comportement et alimentation

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1976
Le comportement du mouton à poil ras des zones tropicales humides est fort peu connu. Son élevage se heurte à de nombreuses difficultés. En plus des maladies diverses, il semble bien que la dégénérescence, les saillies et gestations précoces, la ...
D. Rombaut, Guy Van Vlaenderen
doaj   +1 more source