Results 71 to 80 of about 1,388 (159)
Nonclinical Development of BCG Replacement Vaccine Candidates
Vaccines, 2013 The failure of current Mycobacterium bovis bacille Calmette–Guérin (BCG) vaccines, given to neonates to protect against adult tuberculosis and the risk of using these live vaccines in HIV-infected infants, has emphasized the need for generating new, more
Bernd Eisele +14 more
doaj +1 more source
Genome sequencing and analysis of a type A Clostridium perfringens isolate from a case of bovine clostridial abomasitis. [PDF]
PLoS ONE, 2012 Clostridium perfringens is a common inhabitant of the avian and mammalian gastrointestinal tracts and can behave commensally or pathogenically. Some enteric diseases caused by type A C.
Victoria J Nowell +5 more
doaj +1 more source
Unique features of β‐cell metabolism are lost in type 2 diabetes
Acta Physiologica, Volume 240, Issue 6, June 2024.Abstract Pancreatic β cells play an essential role in the control of systemic glucose homeostasis as they sense blood glucose levels and respond by secreting insulin. Upon stimulating glucose uptake in insulin‐sensitive tissues post‐prandially, this anabolic hormone restores blood glucose levels to pre‐prandial levels. Maintaining physiological glucose
Felipe Muñoz +4 more
wiley +1 more source
Toxins, 2018 The largest superfamily of bacterial virulence factors is pore-forming toxins (PFTs). PFTs are secreted by both pathogenic and non-pathogenic bacteria. PFTs sometimes kill or induce pro-pathogen signaling in mammalian cells, all primarily through plasma ...
Sucharit Ray +2 more
doaj +1 more source
Tau induces inflammasome activation and microgliosis through acetylating NLRP3
Clinical and Translational Medicine, Volume 14, Issue 3, March 2024.• NLRP3 inflammasome is activated with increased NLRP3 acetylation in Tauopathy transgenic mice and AD patients. • Tau promotes NLRP3 acetylation and inflammasome activation dependent on K18 acetyltransferase activity domain. • Tau directly acetylates NLRP3 at K21, K22 and K24 site at its PYD domain and thereby induce inflammasome activation in vitro. •
Lun Zhang +23 more
wiley +1 more source
Assessment of Brown Adipocyte Thermogenic Function by High-throughput Respirometry
Bio-Protocol, 2015 Brown adipose tissue (BAT) has the unique ability to dramatically increase mitochondrial uncoupled fuel oxidation for thermogenesis in response to adrenergic stimulation.
Kiana Mahdaviani +2 more
doaj +1 more source
An upstream regulatory sequence stimulates expression of the perfringolysin O gene of Clostridium perfringens [PDF]
Infection and Immunity, 1991 The structural gene for perfringolysin O (pfoA), a thiol-activated hemolysin of Clostridium perfringens, was cloned into Escherichia coli JM109 on a 4.6-kilobase (kb) EcoRI-NdeI fragment which contained the 1.7-kb pfoA gene and an upstream 2.9-kb region. An E.
T, Shimizu +3 more
openaire +2 more sources
The FASEB Journal, Volume 38, Issue 2, 31 January 2024.This study provides a comprehensive overview of disrupted cholesterol homeostasis pathways in the pregnancy disorder preeclampsia. Additionally, we investigated a cell model designed to simulate this disorder by inducing continuous and intermittent hypoxic episodes.
Barbara Fuenzalida +5 more
wiley +1 more source
ToxinsBy producing alpha toxin (PLC) and perfringolysin O (PFO), Clostridium perfringens type A strains are the most common cause of traumatic gas gangrene. C. perfringens cannot synthesize branched-chain amino acids (BCAAs), so BCAA transporters are essential
Jihong Li +3 more
doaj +1 more source
Functional analysis of the VirSR phosphorelay from Clostridium perfringens. [PDF]
PLoS ONE, 2009 Toxin production in Clostridium perfringens is controlled by the VirSR two-component signal transduction system, which comprises the VirS sensor histidine kinase and the VirR response regulator.
Jackie K Cheung +3 more
doaj +1 more source