Results 81 to 90 of about 1,388 (159)

An Autopsy Case of Fulminant Systemic Infection of Clostridium perfringens With a Diverse Role of Toxins in a Healthy Patient

Case Reports in Pathology, Volume 2024, Issue 1, 2024.
We herein report an autopsy case of a fulminant Clostridium perfringens (C. perfringens or Welch bacilli) infection in a healthy adult. A 72‐year‐old, immunocompetent man visited the emergency department with lower back pain, and blood test revealed hemolytic attack.
Ayano Osamura, Hiromi Onizuka, Kenta Masui, Kumiko Murakami, Tomoko Yamamoto, Yoji Nagashima, Munekazu Takeda, Atsushi Kurata, Tanja Batinac   +8 more
wiley   +1 more source

The EngCP endo α-N-acetylgalactosaminidase is a virulence factor involved in Clostridium perfringens gas gangrene infections

International Journal of Medical Microbiology, 2020
Clostridium perfringens is the causative agent of human clostridial myonecrosis; the major toxins involved in this disease are α-toxin and perfringolysin O.
Jackie K. Cheung, Vicki Adams, Danielle D’Souza, Meagan James, Christopher J. Day, Michael P. Jennings, Dena Lyras, Julian I. Rood   +7 more
doaj   +1 more source

Preclinical evaluation of VAX-IP, a novel bacterial minicell-based biopharmaceutical for nonmuscle invasive bladder cancer

Molecular Therapy: Oncolytics, 2016
The development of new therapies that can prevent recurrence and progression of nonmuscle invasive bladder cancer remains an unmet clinical need. The continued cost of monitoring and treatment of recurrent disease, along with its high prevalence and ...
Shingo Tsuji, Xuguang Chen, Bryan Hancock, Veronica Hernandez, Barbara Visentin, Katherine Reil, Roger Sabbadini, Matthew Giacalone, WT Godbey   +8 more
doaj   +1 more source

How interaction of perfringolysin O with membranes is controlled by sterol structure, lipid structure, and physiological low pH: insights into the origin of perfringolysin O-lipid raft interaction.

The Journal of biological chemistry, 2008
Perfringolysin O (PFO) is a sterol-dependent, pore-forming cytolysin. To understand the molecular basis of PFO membrane interaction, we studied its dependence upon sterol and lipid structure and aqueous environment. PFO interacted with diverse sterols, although binding was affected by double bond location in the sterol rings, sterol side chain ...
Lindsay D, Nelson, Arthur E, Johnson, Erwin, London   +2 more
openaire   +2 more sources

A Nonpolycationic Fully Proteinaceous Multiagent System for Potent Targeted Delivery of siRNA

Molecular Therapy: Nucleic Acids, 2014
Protein-based methods of targeted short-interfering RNA (siRNA) delivery have the potential to solve some of the problems faced by nanoparticle-based methods, such as poor pharmacokinetics and biodistribution, low tumor penetration, and polydispersity ...
David V Liu, Nicole J Yang, K Dane Wittrup   +2 more
doaj   +1 more source

The presence of differentiated C2C12 muscle cells enhances toxin production and growth by Clostridium perfringens type A strain ATCC3624

Virulence
Clostridium perfringens type A causes gas gangrene, which involves muscle infection. Both alpha toxin (PLC), encoded by the plc gene, and perfringolysin O (PFO), encoded by the pfoA gene, are important when type A strains cause gas gangrene in a mouse ...
Jihong Li, Sameera Sayeed, Bruce A. McClane   +2 more
doaj   +1 more source

A biotinylated perfringolysin O derivative: A new probe for detection of cell surface cholesterol

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1997
theta-Toxin is a cholesterol-binding, pore-forming cytolysin of Clostridium perfringens. To detect cell surface cholesterol, we prepared a theta-toxin derivative, BC theta by biotinylation of a protease-nicked theta-toxin, which has the same binding affinity for cholesterol as theta-toxin without cytolytic activity.
Iwamoto, Machiko, Morita, Ikuo, Fukuda, Mitsugu, Murota, Sei-itsu, Ando, Susumu, Ohno-Iwashita, Yoshiko   +5 more
openaire   +2 more sources

Immunogenic and neutralization efficacy of recombinant perfringolysin O of Clostridium perfringens and its C-terminal receptor-binding domain in a murine model. [PDF]

Immunol Res, 2022
Singh A, Rawat P, Choudhury D, Dixit A.
europepmc   +1 more source

Cholesterol Alone is Sufficient to Specifically Trigger Perfringolysin O Oligomerization and Prepore Formation

The FASEB Journal, 2006
Perfringolysin O (PFO) is a pore‐forming toxin secreted by Clostridium perfringens. Upon encountering a cholesterol‐containing membrane, the toxin oligomerizes and spontaneously inserts into the bilayer to form a large pore (diameter ~300 Å).
Alejandro P Heuck, Rodney K Tweten, Arthur E Johnson   +2 more
openaire   +1 more source

Probing Genomic Aspects of the Multi-Host Pathogen Clostridium perfringens Reveals Significant Pangenome Diversity, and a Diverse Array of Virulence Factors

Frontiers in Microbiology, 2017
Clostridium perfringens is an important cause of animal and human infections, however information about the genetic makeup of this pathogenic bacterium is currently limited.
Raymond Kiu, Raymond Kiu, Shabhonam Caim, Sarah Alexander, Purnima Pachori, Lindsay J. Hall   +5 more
doaj   +1 more source