Results 121 to 130 of about 22,988 (259)

Small Strokes, Big Impact: Excessive Mortality After Acute Ischemic Stroke in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Acute ischemic stroke (AIS) in those with Parkinson's disease (PD) is a growing healthcare burden but mortality studies are significantly lacking. Objective To map short‐ and long‐term survival, stratified by relevant comorbidities and stroke characteristics.
Lee E. Neilson, Chen Lin, Anusha Mishra, Gregory D. Scott   +3 more
wiley   +1 more source

White Matter Matters: A Magnetic Resonance Imaging Study with Clinical Correlates in Primary Brain Calcification

Movement Disorders, EarlyView.
Abstract Background Primary brain calcification (PBC) is a genetic disease featuring movement disorders, cognitive impairment, and/or psychiatric symptoms. Computed tomography (CT) scan identifies brain calcification but poorly correlates with patients' clinical phenotype; the role of magnetic resonance imaging (MRI) is yet undefined.
Giovanni Librizzi, Giulia Bonato, Matilde Corazza, Irene Guerra, Francesca Pistonesi, Cinzia Bertolin, Leonardo Salviati, Angelo Antonini, Renzo Manara, Miryam Carecchio   +9 more
wiley   +1 more source

Clinicopathological significance of loss of Y chromosome in male meningiomas

The Journal of Pathology, EarlyView.
Abstract Male meningiomas, comprising approximately 30% of all meningiomas, are more frequently high‐grade and associated with poorer clinical outcomes compared to their female counterparts. Although Y chromosome alterations have been studied in various male‐predominant tumors, a limited number of studies have evaluated their role in meningiomas.
Maki Sakaguchi, Masafumi Horie, Yukinobu Ito, Shingo Tanaka, Hiroko Ikeda, Mitsutoshi Nakada, Akihiko Yoshizawa, Daichi Maeda   +7 more
wiley   +1 more source

Flow-induced Klf4-Akt signaling links EC cycling to mural cell defects in arterial-venous malformations. [PDF]

Theranostics
Lin Y, Hashemi Z, Zhang Q, Di Y, Behera T, Gahn J, Banerjee K, Wu F, Andorfer K, Singhal M, Seebauer C, Ola R.   +11 more
europepmc   +1 more source

Refractory Lung Diseases: From Cellular Structures, Molecular Mechanisms to Therapeutic Strategies

Pediatric Discovery, EarlyView.
ABSTRACT Refractory lung diseases (RLDs) encompass a spectrum of progressive pulmonary disorders, including acute respiratory distress syndrome (ARDS), bronchopulmonary dysplasia (BPD), and idiopathic pulmonary fibrosis (IPF). These conditions are defined by poor responsiveness to current therapeutic interventions and pose substantial clinical ...
Yiheng Qiu, Xiangyu Dong, Yi Zhu, Nicole Miranda, Awele Chukwura, Yan Peng, Sarina Zhao, Michelle Xiang, Peyton McGuire, Ava Zou, Lucas Zhang, Jiaming Fan, Linghuan Zhang   +12 more
wiley   +1 more source

Notch3 regulates pericyte phenotypic plasticity in colorectal cancer. [PDF]

Commun Biol
Chalkidi N, Stavropoulou A, Arvaniti VZ, Paraskeva C, Monogyiou A, Sakkou M, Nikolaou C, Koliaraki V.   +7 more
europepmc   +1 more source

Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy

PROTEOMICS, EarlyView.
ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling, Dounia Bouragba, Elisa Negroni, Capucine Trollet, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +6 more
wiley   +1 more source

CO₂ inhalation enhances pericyte-mediated neurovascular protection in ischemic stroke and remains safe in hemorrhagic stroke. [PDF]

J Cereb Blood Flow Metab
Yoon CE, Jung JW, Kim YB, Song J, Joo H, Kim B, Kwon I, Yoon SS, Kim JS, Choi HY, Kim YD, Heo JH, Nam HS.   +12 more
europepmc   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

The Novel Soluble Guanylate Cyclase Stimulator Attenuates Acute Lung Injury via Inhibiting Pericyte Phenotypic Transition. [PDF]

Int J Mol Sci
Huang YL, Li S, Li X, Zhang JS, Shi YX, Su GX, Zhang Y, Xue R, Li JC, Fan QY, Zheng ZB, Deng Y, Zhang YZ.   +12 more
europepmc   +1 more source