Results 161 to 170 of about 29,574 (291)

Clazosentan Attenuates Endothelin-1-Induced ETA Protein Upregulation and Contractile Sensitization in Brain Pericytes. [PDF]

Pharmaceutics
Chikamatsu G, Nakagawa S, Morofuji Y, Shiozaki E, Ogawa Y, Okamura K, Matsunaga Y, Watanabe D, Walter FR, Izumo T, Niwa M, Deli MA, Matsuo T.   +12 more
europepmc   +1 more source

Peril in perishing pericytes [PDF]

Journal of the National Cancer Institute, 2015
openaire   +2 more sources

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

A dual role of AcSDKP in chronic kidney disease: Targeting pericyte-driven fibrosis and vascular repair via VEGF/FGFR1 while eliciting a compensatory FGFR1 upregulation in apoptotic tubular cells. [PDF]

PLoS One
Zhu S, Shi L, Huang L, Cui N, Chen R, Jiang L, Zhang A, Xu Y, Li X.   +8 more
europepmc   +1 more source

Emerging Human‐Based Research Technologies for Investigating the Pathomechanisms and Therapies for Vascular Diseases

iNew Medicine, EarlyView.
ABSTRACT It is estimated that a large proportion of drug candidates fail in human clinical trials, mainly because animal models cannot fully replicate human disease and because of differential responses to various medications between humans and animals.
Weiping Ding, Iqra Ilyas, Suowen Xu
wiley   +1 more source

Cerebral Intramural Cells: A Missing Cellular Link Between Vascular Aging and Alzheimer's Disease. [PDF]

Int J Mol Sci
Arbănași EM, Arbănași EM, Boghițoiu TG, Cărare SA, Cordoș BA, Braysh K, Suciu N, Chinezu L, Manu DR, Montagne A, Dewing J, Russu E, Bănescu CV, Voidăzan ST, Cărare RO.   +14 more
europepmc   +1 more source

Recent advances and clinical applications of 3D printing for female reproductive organ regeneration and gynecological disease

Interdisciplinary Medicine, EarlyView.
This comprehensive review highlights the transformative role of 3D printing and bioprinting technologies in the regeneration of female reproductive organs and the treatment of gynecological diseases. Unlike previous overviews that focus narrowly on isolated applications, this work provides an integrative analysis of recent clinical and preclinical ...
Chan Hum Park, In‐Sun Hong
wiley   +1 more source

Therapeutic Potential of Platelet-Derived Growth Factor B-Modified Nanoparticles in Enhancing Pericyte Activation for Acute Ischemic Stroke. [PDF]

eNeuro
Karashima S, Arimura K, Hatae R, Takagishi S, Narahara S, Kawano T, Tanaka S, Kurogi R, Nakamizo A, Murata M, Yoshimoto K.   +10 more
europepmc   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

Selective Pericyte Recruitment to EC-lined Tubes, Vessel Assembly Enhancement Through Pericyte TIMP-3 Induction, and Pericyte TBX2 in Capillary Formation and Maturation

Capillaries, the smallest blood vascular networks, are formed by narrow and elongated endothelial cell (EC)-lined tubes with associated pericytes anchored to the abluminal tube surface.
Kaluguina, Ksenia Marilyn Yrigoin
core