Results 181 to 190 of about 39,702 (305)

Delivery of nano‐formulated drugs to solid tumours is selectively increased by co‐application of the vascular disrupting agent CA4P

British Journal of Pharmacology, EarlyView.
Background and purpose Nano‐formulated chemotherapeutics prolong systemic availability of drugs and can reduce systemic toxicity, but their accumulation in solid tumours is often limited and unpredictable. Broadly applicable strategies to selectively enhance tumour delivery are lacking.
Annabel Kitowski, Constanze Heise, Stefanie Sperling, Jasmin Hotz, Danica Bajic, Marina Rubey, Kathrin Klar, Georg Höfner, Julien Vollaire, Veronique Josserand, Jean‐Luc Coll, Oliver Thorn‐Seshold, Petar Marinković, Julia Thorn‐Seshold   +13 more
wiley   +1 more source

GLP-1 activates K_ATP channels in coronary pericytes as the effector of brain-gut-heart signalling mediating cardioprotection. [PDF]

Nat Commun
Mastitskaya S, de Freitas FSS, Evans LE, Attwell D.   +3 more
europepmc   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Targeting angiogenesis: Lessons from 25 years of normalizing tumor vasculature. [PDF]

Cell
Subudhi S, Lee S, Jain RK.
europepmc   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Research advances in improving drug efficacy through remodeling of tumor vascular function by different aerobic exercises. [PDF]

Front Sports Act Living
Hou S, Sun R, Hu S, Zhang Q, Sun X, Wang L, Wu J.   +6 more
europepmc   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

The Novel Soluble Guanylate Cyclase Stimulator Attenuates Acute Lung Injury via Inhibiting Pericyte Phenotypic Transition. [PDF]

Int J Mol Sci
Huang YL, Li S, Li X, Zhang JS, Shi YX, Su GX, Zhang Y, Xue R, Li JC, Fan QY, Zheng ZB, Deng Y, Zhang YZ.   +12 more
europepmc   +1 more source

Downregulation of lysyl oxidase protects retinal endothelial cells from high glucose–induced apoptosis [PDF]

, 2017
Kim, Dongjoon, Mecham, Robert P, Roy, Sayon, Trackman, Philip C   +3 more
core   +2 more sources

Peril in perishing pericytes [PDF]

Journal of the National Cancer Institute, 2015
openaire   +2 more sources