Results 171 to 180 of about 22,988 (259)

The regulation of placental pericyte function through transforming growth factor β-1 signalling. [PDF]

Sci Rep
MacPhee CA, Natale BV, Noordhof C, Wang S, Lima PDA, Natale DRC.   +5 more
europepmc   +1 more source

TREM2+ macrophages accumulate in childhood IgA nephropathy and soluble TREM2 represents a reliable non‐invasive biomarker

Experimental Physiology, EarlyView.
Abstract IgA nephropathy (IgAN) is a common type of primary glomerulonephritis in children. The pathogenesis of childhood IgAN remains unclear, and there is a lack of effective non‐invasive biomarkers for this disease. Single‐cell RNA sequencing was performed in children with IgAN to delineate cellular and molecular compositions, and subcluster ...
Ling Yu, Xuan Gang, Jingjing Wang, Guoping Huang, Qiuyu Li, Weizhong Gu, Haidong Fu, Jianhua Mao   +7 more
wiley   +1 more source

The PDGFBB-PDGFRβ Pathway and Laminins in Pericytes Are Involved in the Temporal Change of AQP4 Polarity during Temporal Lobe Epilepsy Pathogenesis. [PDF]

eNeuro
Lin L, Tang H, Cui K, Kang Z, Pan T, Feng C, Zhao X, Wang J, Chen Z, Jiang Z, Wu G.   +10 more
europepmc   +1 more source

Adipose tissue‐derived small extracellular vesicles and blood–brain barrier function in adults with overweight and obesity

Experimental Physiology, EarlyView.
Abstract Obesity is associated with adverse changes in brain structure and function, in part, through crosstalk between adipose tissue (AT) and the brain. AT releases small extracellular vesicles (sEV) that can cross the blood–brain barrier (BBB) and modulate multiple pathophysiological pathways, including BBB function; however, this has never been ...
Shalini Mishra, Yixin Su, Sangeeta Singh, Ashish Kumar, Fang‐Chi Hsu, Gagan Deep, Tina E. Brinkley   +6 more
wiley   +1 more source

The crosstalk between blood-brain barrier and neural cells: bidirectional regulation of brain function and pathology. [PDF]

Biochem Biophys Rep
Ju M, Shen H, Zhang X, Tian M, Zhang L.
europepmc   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Publisher Correction: Non-invasive characterization of pericyte dysfunction in mouse brain using functional ultrasound localization microscopy. [PDF]

Nat Biomed Eng
Thalgott JH, Zucker N, Deffieux T, Koopman MS, Dizeux A, Avramut CM, Koning RI, Mager HJ, Rabelink TJ, Tanter M, Lebrin F.   +10 more
europepmc   +1 more source

Lactate potentiates NMDA receptor currents via an intracellular redox mechanism targeting GluN2B subunits: implications for synaptic plasticity

The Journal of Physiology, EarlyView.
Abstract figure legend Astrocyte‐derived lactate enhances neuronal NMDA receptor (NMDAR) function and synaptic plasticity through a redox‐ and CaMKII‐dependent mechanism. Lactate enters neurons via monocarboxylate transporters (MCTs) and is oxidized by lactate dehydrogenase (LDH) to pyruvate, generating NADH and increasing the intracellular NADH/NAD ...
Hubert Fiumelli, Gabriel Herrera‐López, Fouad Lemtiri‐Chlieh, Lorène Mottier, John Girgis, Carine Ben‐Adiba, Pascal Jourdain, Nicolò Carrano, Hanan Mahmood, Amanda Ooi, Stefan T. Arold, Monica Di Luca, Fabrizio Gardoni, Pierre J. Magistretti   +13 more
wiley   +1 more source

Eppur si muove: the dynamic brain pericyte. [PDF]

Fluids Barriers CNS
Wilhelm I, Győri F, Dudás T, Nagy V, Shreeya T, Krecsmarik M, Farkas AE, Fazakas C, Krizbai IA.   +8 more
europepmc   +1 more source

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

The Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor, Miguel Martin‐Aragon Baudel, Eric Pereira da Silva, Johannes W. Hell, Madeline Nieves‐Cintron, Manuel F. Navedo   +5 more
wiley   +1 more source