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Modifications of perineuronal nets to regulate plasticity

, 2018
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Neurocan Contributes to Perineuronal Net Development

Neuroscience, 2020
Perineuronal nets (PNs) are matrix molecule assemblies surrounding neuronal somata, dendrites and axon initial segments in a lattice-like appearance. PN molecules are involved in many structural and physiological processes during development and in adulthood, suggesting a crucial role in normal brain function.
Sophie, Schmidt, Thomas, Arendt, Markus, Morawski, Mandy, Sonntag   +3 more
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Perineuronal nets: past and present

Trends in Neurosciences, 1998
Golgi ranked the peripheral reticulum--which adheres intimately to nerve cell surfaces--alongside the intracellular reticulum, or Golgi apparatus,which immortalized his name. At first dismissed as an artefact of capricious staining techniques, this peripheral reticulum, or perineuronal net, is now recognized as a genuine entity in neurocytology.
M R, Celio, R, Spreafico, S, De Biasi, L, Vitellaro-Zuccarello   +3 more
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Perineuronal nets in the auditory system

Hearing Research, 2015
Perineuronal nets (PNs) are a unique and complex meshwork of specific extracellular matrix molecules that ensheath a subset of neurons in many regions of the central nervous system (CNS). PNs appear late in development and are supposed to restrict synaptic plasticity and to stabilize functional neuronal connections.
Mandy, Sonntag, Maren, Blosa, Sophie, Schmidt, Rudolf, Rübsamen, Markus, Morawski   +4 more
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Perineuronal Nets Protect Fear Memories from Erasure

Science, 2009
Adult Fears Why are fear memories almost impossible to get rid of—even with extensive extinction training? Animal studies have shown that the efficacy of extinction learning depends on age. Fear memories in young animals can be permanently erased, but in adults they can be easily recovered after extinction ...
Gogolla, N., Caroni, P., Luthi, A., Herry, C.   +3 more
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Perineuronal nets’ role in metabolism

American Journal of Physiology-Endocrinology and Metabolism
Perineuronal nets (PNNs), specialized extracellular matrix (ECM) structures that envelop neurons, have recently been recognized as key players in the regulation of metabolism. This review explores the growing body of knowledge concerning PNNs and their role in metabolic control, drawing insights from recent research and relevant studies.
Nan Zhang, Beite Song, Peng Bai, Li Du, Lulu Chen, Yong Xu, Tianshu Zeng   +6 more
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Microglia-mediated degradation of perineuronal nets promotes pain

Science, 2022
Activation of microglia in the spinal cord dorsal horn after peripheral nerve injury contributes to the development of pain hypersensitivity. How activated microglia selectively enhance the activity of spinal nociceptive circuits is not well understood. We discovered that after peripheral nerve injury, microglia degrade extracellular matrix structures,
Shannon Tansley, Ning Gu, Alba Ureña Guzmán, Weihua Cai, Calvin Wong, Kevin C. Lister, Einer Muñoz-Pino, Noosha Yousefpour, R. Brian Roome, Jordyn Heal, Neil Wu, Annie Castonguay, Graham Lean, Elizabeth M. Muir, Artur Kania, Masha Prager-Khoutorsky, Ji Zhang, Christos G. Gkogkas, James W. Fawcett, Luda Diatchenko, Alfredo Ribeiro-da-Silva, Yves De Koninck, Jeffrey S. Mogil, Arkady Khoutorsky   +23 more
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Perineuronal nets potentially protect against oxidative stress

Experimental Neurology, 2004
A specialized form of extracellular matrix (ECM) termed perineuronal nets (PNs) consisting of large aggregating chondroitin sulfate proteoglycans (CSPGs), with hyaluronan and tenascin as main components, surrounds subpopulations of neurons.
Markus, Morawski, Martina K, Brückner, Peter, Riederer, Gert, Brückner, Thomas, Arendt   +4 more
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The two faces of perineuronal nets

NeuroReport, 2000
Perineuronal nets are extracellular structures enwrapping the soma and proximal dendrites of some neurons known to be parvalbumin immunoreactive. The composition of the nets is not completely known, but it can change between different neurons. We studied the heterogeneous composition of a specific component of perineuronal nets, the signaling molecule ...
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The Perineuronal Net: A Weapon for a Challenge

Journal of the History of the Neurosciences, 1999
Theories and data do not always fit and sometimes are sources of conflicts among scientists. This is the case of a morphological structure, the perineuronal net, which was denied on the basis of an ideological conflict between two giants of neurosciences: Camillo Golgi and Santiago Ramon y Cajal. The perineuronal net is a reticular structure enveloping
R, Spreafico, S, De Biasi, L, Vitellaro-Zuccarello   +2 more
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