The Effect of Mild Traumatic Brain Injury on Perineuronal Nets Surrounding Neocortical Parvalbumin Interneurons [PDF]
, 2023 Mild traumatic brain injury (mTBI) is an extremely common affliction with an estimated 42 million people being affected by it worldwide each year. It can lead to a range of long-term chronic issues and the underlying pathology is not well understood ...
Lowman, Olivia
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Diverse developmental trajectories of perineuronal nets during vertebrate nervous system construction [PDF]
, 2018 2018 Spring.Includes bibliographical references.In the central nervous system, aggregated extracellular matrix compounds known as perineuronal nets (PNNs) shape patterns of neural connectivity over development. Removing PNNs restores juvenile-like states
Edwards, Jacob
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Alteration of perineuronal nets and parvalbumin interneurons in prefrontal cortex and hippocampus, and correlation with blood corticosterone in activity-based anorexia model mice [PDF]
Anorexia nervosa (AN) is an eating disorder characterized by restricted energy intake, severely underweight status, and frequent hyperactivity. Previous research has shown structural and functional alterations in the medial prefrontal cortex (mPFC) and ...
Kawai, Hiroki +6 more
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Functional screening for gene trap mutants involved in perineuronal net formation. [PDF]
A tissue’s cells function within the context of an extracellular matrix (ECM) of glycosylated and crosslinked proteins that provide structural support and adhesion, while also modulating intercellular communication.
Abbasi, Adil
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NPY-Y1 receptor signaling controls spatial learning and perineuronal net expression [PDF]
, 2021 Bertocchi, I. +5 more
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Editorial: Perineuronal Nets as Therapeutic Targets for the Treatment of Neuropsychiatric Disorders [PDF]
Dysregulated synaptic plasticity and excitatory inhibitory (E/I) imbalance are molecular hallmarks of multiple neuropsychiatric disorders. Perineuronal nets (PNNs) are condensed portions of the extracellular matrix (ECM) that stabilize homeostatic ...
Browne, Caroline A. +3 more
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The Pathophysiological Underpinnings of Gamma-Band Alterations in Psychiatric Disorders [PDF]
Investigating the biophysiological substrates of psychiatric illnesses is of great interest to our understanding of disorders' etiology, the identification of reliable biomarkers, and potential new therapeutic avenues.
Battelli L. +8 more
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Parvalbumin and autism: different causes, same effect? [PDF]
, 2016 Filice, Federica, Schwaller, Beat
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Swish!-All I Hear is Net-Perineuronal Net That is! [PDF]
Epilepsy CurrStafstrom CE.
europepmc +1 more source
, 2018 Perineuronal nets (PNNs) are a form of aggregate Extracellular Matrix (ECM) in the brain. Recent evidence suggests that the postnatal deposition of PNNs may play an active role in regulating neuroplasticity and, potentially, neurological disorders ...
Abraham, Reena +5 more
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