Results 111 to 120 of about 5,812 (218)

Breast Cancer Brain Metastasis: Bridging Biological Mechanisms to Therapeutic Innovations

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Breast cancer brain metastasis (BCBrM) is driven by a multistep metastatic cascade and shaped by dynamic tumor–brain interactions. This review integrates current mechanistic insights, from molecular signaling pathways to immune evasion, and evaluates preclinical models and emerging therapies.
Jing Feng, Yuwei Tao, Fengkai Li, Suling Liu   +3 more
wiley   +1 more source

Alpha-pinene and dizocilpine (MK-801) attenuate kindling development and astrocytosis in an experimental mouse model of epilepsy

IBRO Reports, 2020
Understanding the molecular and cellular mechanisms involved during the onset of epilepsy is crucial for elucidating the overall mechanism of epileptogenesis and therapeutic strategies.
Hiroshi Ueno, Atsumi Shimada, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara   +9 more
doaj   +1 more source

Extracellular matrix of the central nervous system: from neglect to challenge [PDF]

, 2018
The basic concept, that specialized extracellular matrices rich in hyaluronan, chondroitin sulfate proteoglycans (aggrecan, versican, neurocan, brevican, phosphacan), link proteins and tenascins (Tn-R, Tn-C) can regulate cellular migration and axonal ...
Dours-Zimmermann, María, Zimmermann, Dieter   +1 more
core  

Prenatal valproate exposure differentially affects parvalbumin-expressing neurons and related circuits in the cortex and striatum of mice [PDF]

, 2016
Autism spectrum disorders (ASD) comprise a number of heterogeneous neurodevelopmental diseases characterized by core behavioral symptoms in the domains of social interaction, language/communication and repetitive or stereotyped patterns of behavior ...
Filice, Federica, Lauber, Emanuel, Schwaller, Beat   +2 more
core   +1 more source

The role of brevican regulation in the antidepressant effects of electroacupuncture in a chronic stress rat model

Journal of Traditional Chinese Medical Sciences
Objective: To investigate the mechanism of electroacupuncture (EA) for treating depression and to explore the role of brevican in the medial prefrontal cortex (mPFC) in modulating stress susceptibility and the antidepressant effects of EA in rats ...
Cong Gai, Zhenyu Guo, Kai Guo, Shixin Yang, Yi Zhang, Huimin Zhu, Feifei Kan, Hongmei Sun, Die Hu   +8 more
doaj   +1 more source

Increased Excitability and Reduced Excitatory Synaptic Input Into Fast-Spiking CA2 Interneurons After Enzymatic Attenuation of Extracellular Matrix

Frontiers in Cellular Neuroscience, 2018
The neural extracellular matrix (ECM) is enriched with hyaluronic acid, chondroitin sulfate proteoglycans (CSPGs) and the glycoprotein tenascin-R, which play important roles in synaptic plasticity, as shown by studies of the CA1 region of the hippocampus.
Hussam Hayani, Inseon Song, Alexander Dityatev, Alexander Dityatev, Alexander Dityatev   +4 more
doaj   +1 more source

Combined Chondroitinase and KLF7 Expression Reduce Net Retraction of Sensory and CST Axons from Sites of Spinal Injury [PDF]

, 2017
Axon regeneration in the central nervous system is limited both by inhibitory extracellular cues and by an intrinsically low capacity for axon growth in some CNS populations.
Blackmore, Murray G., Hess, Evan, Nienhaus, Christopher, Wang, Zimei, Winsor, Kristen N.   +4 more
core   +1 more source

Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets.

PLoS ONE, 2015
ObjectivePerineuronal nets (PN) form a specialized extracellular matrix around certain highly active neurons within the central nervous system and may help to stabilize synaptic contacts, promote local ion homeostasis, or play a protective role.
Scott D Z Eggers, Anja K E Horn, Sigrun Roeber, Wolfgang Härtig, Govind Nair, Daniel S Reich, R John Leigh   +6 more
doaj   +1 more source

Targeting Oxidative Stress and Aberrant Critical Period Plasticity in the Developmental Trajectory to Schizophrenia [PDF]

, 2017
Schizophrenia is a neurodevelopmental disorder reflecting a convergence of genetic risk and early life stress. The slow progression to first psychotic episode represents both a window of vulnerability as well as opportunity for therapeutic intervention ...
Cuenod, Michel, Do, Kim Q., Hensch, Takao K.   +2 more
core  

Scaffolds for 3D in vitro culture of neural lineage cells. [PDF]

, 2017
Understanding how neurodegenerative disorders develop is not only a key challenge for researchers but also for the wider society, given the rapidly aging populations in developed countries.
Cameron, Neil R., Laslett, Andrew, Murphy, Ashley R., O'Brien, Carmel M.   +3 more
core   +1 more source