Results 1 to 10 of about 356,744 (339)

Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock [PDF]

Genes & Development, 2014
The mammalian circadian clock is based on a transcription–translation feedback loop in which CLOCK and BMAL1 proteins act as transcriptional activators of Cryptochrome and Period genes, which encode proteins that repress CLOCK–BMAL1 with a periodicity of
Rui Ye, Cristopher P. Selby, Yi‐Ying Chiou, Irem Ozkan‐Dagliyan, Shobhan Gaddameedhi, Aziz Sancar   +5 more
semanticscholar   +6 more sources

Cysteine Oxidation Promotes Dimerization/Oligomerization of Circadian Protein Period 2 [PDF]

Biomolecules, 2022
The molecular circadian clock is based on a transcriptional/translational feedback loop in which the stability and half-life of circadian proteins is of importance.
Fernando Martin Baidanoff, Laura Lucía Trebucq, Santiago Andrés Plano, Phillip Eaton, Diego Andrés Golombek, Juan José Chiesa   +5 more
doaj   +6 more sources

Human casein kinase Iδ phosphorylation of human circadian clock proteins period 1 and 2 [PDF]

FEBS Letters, 2001
Casein kinase Iϵ (CKIϵ), a central component of the circadian clock, interacts with and phosphorylates human period protein 1 (hPER1) [Keesler, G.A. et al. (2000) NeuroReport 5, 951–955]. A mutation in CKIϵ causes a shortened circadian period in Syrian Golden hamster. We have now extended our previous studies to show that human casein kinase Iδ (hCKIδ),
Fernando Camacho, Maria Roberta Cilio, Yixuan Guo, David M. Virshup, Kamala D. Patel, Olga Khorkova, S.D. Styren, B. Morse, Zhengbin Yao, George A. Keesler   +9 more
semanticscholar   +5 more sources

Mutual Antagonism between Circadian Protein Period 2 and Hepatitis C Virus Replication in Hepatocytes

PLoS ONE, 2013
Background Hepatitis C virus (HCV) infects approximately 3% of the world population and is the leading cause of liver disease, impacting hepatocyte metabolism, depending on virus genotype.
Giorgia Benegiamo, Gianluigi Mazzoccoli, Francesco Cappello, Francesca Rappa, Nunzia Scibetta, Jude A. Oben, Azzura Greco, Roger Williams, Angelo Andriulli, Manlio Vinciguerra, Valerio Pazienza   +10 more
semanticscholar   +8 more sources

A Small Molecule Modulates Circadian Rhythms through Phosphorylation of the Period Protein [PDF]

Angewandte Chemie International Edition, 2011
Time shift A high-throughput cell-based screen identified a benzothiazole analogue, LH846, which induces period lengthening of the circadian rhythm. Affinity chromatography coupled with mass spectrometry and genomic analysis identified protein kinase CKIδ as the biological target of LH846 (see picture).
Jae Wook Lee, Tsuyoshi Hirota, Eric C. Peters, Michael Garcia, Rodolfo Gonzalez, Charles Y. Cho, Xu Wu, Peter G. Schultz, Steve A. Kay   +8 more
  +6 more sources

Structure-based design and classifications of small molecules regulating the circadian rhythm period

Scientific Reports, 2021
Circadian rhythm is an important mechanism that controls behavior and biochemical events based on 24 h rhythmicity. Ample evidence indicates disturbance of this mechanism is associated with different diseases such as cancer, mood disorders, and familial ...
Seref Gul, Fatih Rahim, Safak Isin, Fatma Yilmaz, Nuri Ozturk, Metin Turkay, Ibrahim Halil Kavakli   +6 more
doaj   +2 more sources

Decoupling PER phosphorylation, stability and rhythmic expression from circadian clock function by abolishing PER-CK1 interaction

Nature Communications, 2022
PERIOD proteins, the core components of the mammalian circadian clock, act as the CK1 scaffold in the negative feedback process. Surprisingly, the mouse circadian clock can function independent of PER phosphorylation and PER abundance rhythms.
Yang An, Baoshi Yuan, Pancheng Xie, Yue Gu, Zhiwei Liu, Tao Wang, Zhihao Li, Ying Xu, Yi Liu   +8 more
doaj   +2 more sources

Phosphorylation Regulating the Ratio of Intracellular CRY1 Protein Determines the Circadian Period [PDF]

Frontiers in Neurology, 2016
The core circadian oscillator in mammals is composed of transcription/translation feedback loop, in which cryptochrome (CRY) proteins play critical roles as repressors of their own gene expression.
Na Liu, E. E. Zhang
semanticscholar   +4 more sources

Drosophila PSI controls circadian period and the phase of circadian behavior under temperature cycle via tim splicing

eLife, 2019
The Drosophila circadian pacemaker consists of transcriptional feedback loops subjected to post-transcriptional and post-translational regulation. While post-translational regulatory mechanisms have been studied in detail, much less is known about ...
Lauren E Foley, Jinli Ling, Radhika Joshi, Naveh Evantal, Sebastian Kadener, Patrick Emery   +5 more
doaj   +2 more sources

FRQ-CK1 interaction determines the period of circadian rhythms in Neurospora

Nature Communications, 2019
Circadian clocks control daily rhythms of molecular and physiological activities. Here, the authors show that the interaction between proteins FRQ and CK1, rather than FRQ stability, is a major rate-limiting step in circadian period determination in the ...
Xiao Liu, Ahai Chen, Angélica Caicedo-Casso, Guofei Cui, Mingjian Du, Qun He, Sookkyung Lim, Hang J. Kim, Christian I. Hong, Yi Liu   +9 more
doaj   +2 more sources