Cysteine Oxidation Promotes Dimerization/Oligomerization of Circadian Protein Period 2 [PDF]
Biomolecules, 2022 The molecular circadian clock is based on a transcriptional/translational feedback loop in which the stability and half-life of circadian proteins is of importance.
Fernando Martin Baidanoff +5 more
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Decoupling circadian clock protein turnover from circadian period determination [PDF]
Science, 2015 Defining necessary circadian clock elements The circadian clock in organisms as diverse as fungi and humans have a rather similar structure: Timing depends on daily cycles of transcription in circuits in which feedback loops control the timing of oscillations. A critical role has been ascribed to negative elements,
Luis Larrondo +4 more
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Phosphorylation Regulating the Ratio of Intracellular CRY1 Protein Determines the Circadian Period [PDF]
Frontiers in Neurology, 2016 The core circadian oscillator in mammals is composed of transcription/translation feedback loop, in which cryptochrome (CRY) proteins play critical roles as repressors of their own gene expression. Although post-translational modifications, such as phosphorylation of CRY1, are crucial for circadian rhythm, little is known about how phosphorylated CRY1 ...
Na Liu, Eric Erquan Zhang
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Regulation of αENaC expression by the circadian clock protein Period 1 in mpkCCDc14 cells [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2010 The epithelial sodium channel (ENaC) mediates the fine-tuned regulation of external sodium (Na) balance. The circadian clock protein Period 1 (Per1) is an aldosterone-induced gene that regulates mRNA expression of the rate-limiting alpha subunit of ENaC (αENaC).
Michelle L. Gumz +6 more
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Circadian Clock Neurons in the Silkmoth Antheraea pernyi: Novel Mechanisms of Period Protein Regulation [PDF]
Neuron, 1996 We examined Period (PER) protein regulation in the brain of the silkmoth Antheraea pernyi. PER expression is restricted to the cytoplasm and axons of eight neurons, with no evidence of temporal movement into the nucleus. These neurons appear to be circadian clock cells, because PER and per mRNA are colocalized and their levels oscillate in these cells,
Ivo Šauman, Steven M. Reppert
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GRK2 Fine-Tunes Circadian Clock Speed and Entrainment via Transcriptional and Post-translational Control of PERIOD Proteins [PDF]
Cell Reports, 2015 The pacemaker properties of the suprachiasmatic nucleus (SCN) circadian clock are shaped by mechanisms that influence the expression and behavior of clock proteins.
Neel Mehta +8 more
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Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance Mitochondria are major cellular energy suppliers and have to cope with changes in nutrient supply and energy demand that naturally occur throughout the day. We obtained the first, to our knowledge, comprehensive mitochondrial proteome around the clock and identified extensive oscillations in mitochondrial protein abundance that ...
Adi Neufeld-Cohen +11 more
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Neuron, 1995 The Drosophila period protein (PER) is a predominantly nuclear protein and a likely component of a circadian clock. PER is required for daily oscillations in the transcription of its own gene and thus participates in a circadian feedback loop.
Kathryn D. Curtin +2 more
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Nuclear Envelope Protein MAN1 Regulates the Drosophila Circadian Clock via Period
Neuroscience Bulletin, 2019 Almost all organisms exhibit ~24-h rhythms, or circadian rhythms, in a plentitude of biological processes. These rhythms are driven by endogenous molecular clocks consisting of a series of transcriptional and translational feedback loops. Previously, we have shown that the inner nuclear membrane protein MAN1 regulates this clock and thus the locomotor ...
Bei Bu +3 more
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Codon usage affects the structure and function of the Drosophila circadian clock protein PERIOD [PDF]
Genes & Development, 2016 Codon usage bias is a universal feature of all genomes, but its in vivo biological functions in animal systems are not clear. To investigate the in vivo role of codon usage in animals, we took advantage of the sensitivity and robustness of the Drosophila circadian system.
Jingjing Fu +7 more
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