Results 101 to 110 of about 356,744 (339)

Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis

Advanced Science, EarlyView.
This study identifies a class of amino acid‐sensing neurons, APCCRH neurons, which regulate BAT thermogenesis. Leucine deficiency alters intrinsic excitability through GCN2 signaling pathway, activating APCCRH neurons, which in turn regulate BAT thermogenesis via projections to the lateral hypothalamus.
Peixiang Luo, Kexin Tong, Yeting Gan, Min Tang, Yuguo Niu, Kan Liu, Shihong Ni, Shangming Wu, Xiaoxue Jiang, Haizhou Jiang, Fei Xiao, Shanghai Chen, Wei Lv, Xiaoying Li, Feixiang Yuan, Feifan Guo   +15 more
wiley   +1 more source

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase.

PLoS Biology, 2010
The circadian clock underlies daily rhythms of diverse physiological processes, and alterations in clock function have been linked to numerous pathologies.
Tsuyoshi Hirota, Jae Wook Lee, Warren G Lewis, Eric E Zhang, Ghislain Breton, Xianzhong Liu, Michael Garcia, Eric C Peters, Jean-Pierre Etchegaray, David Traver, Peter G Schultz, Steve A Kay   +11 more
doaj   +1 more source

The functional interplay between protein kinase CK2 and CCA1 transcriptional activity is essential for clock temperature compensation in Arabidopsis. [PDF]

PLoS Genetics, 2010
Circadian rhythms are daily biological oscillations driven by an endogenous mechanism known as circadian clock. The protein kinase CK2 is one of the few clock components that is evolutionary conserved among different taxonomic groups.
Sergi Portolés, Paloma Más
doaj   +1 more source

Radical pairs can explain magnetic field and lithium effects on the circadian clock [PDF]

arXiv, 2021
Drosophila's circadian clock can be perturbed by magnetic fields, as well as by lithium administration. Cryptochromes are critical for the circadian clock. Further, the radical pairs in cryptochrome also can explain magnetoreception in animals. Based on a simple radical pair mechanism model of the animal magnetic compass, we show that both magnetic ...
arxiv  

Kernel Architecture of the Genetic Circuitry of the Arabidopsis Circadian System [PDF]

PLoS Comput. Biol. 12, e1004748 (2016), 2016
A wide range of organisms features molecular machines, circadian clocks, which generate endogenous oscillations with ~24 h periodicity and thereby synchronize biological processes to diurnal environmental fluctuations. Recently, it has become clear that plants harbor more complex gene regulatory circuits within the core circadian clocks than other ...
arxiv   +1 more source

Cysteine oxidation promotes dimerization/oligomerization of circadian protein period

, 2022
Abstract: The molecular circadian clock is based on a transcriptional/translational feedback loop in which the stability and half-life of circadian proteins is of importance. Cysteine residues of proteins are subject to several redox reactions leading to S-thiolation and disulfide bond formation, altering protein stability and function.
Baidanoff, Fernando Martín, Trebucq, Laura Lucía, Plano, Santiago Andrés, Eaton, Phillip, Golombek, Diego A., Chiesa, Juan José   +5 more
openaire   +1 more source

Advanced Microfluidic‐Based Wearable Electrochemical Sensors for Continuous Biochemical Monitoring

Advanced Electronic Materials, EarlyView.
Microfluidic‐based wearable electrochemical sensors are transforming non‐invasive health monitoring through real‐time biochemical analysis of sweat, saliva, and interstitial fluid. This review explores advances in microfluidic design, fabrication, and sensor integration while addressing biofluid variability, material compatibility, and scalability.
Sehyun Park, Seongyeop Kim, Soojin Lee, Vladimir V. Tsukruk, SeungHyun Park, Hyo‐Ryoung Lim   +5 more
wiley   +1 more source

Phosphorylation of the Cryptochrome 1 C-terminal Tail Regulates Circadian Period Length*

Journal of Biological Chemistry, 2013
Background: Cryptochromes (CRYs) are transcriptional repressors that are critical components of the circadian clock. Results: We have identified a phosphorylation site in the CRY1 tail that is negatively regulated by the DNA repair enzyme DNA-dependent ...
Peng Gao, Seung-Hee Yoo, Kyung-jong Lee, Clark Rosensweig, J. Takahashi, B. Chen, C. Green   +6 more
semanticscholar   +1 more source

A Case of Prader‐Willi Syndrome With a Deletion Including MAGEL2, NDN, and MKRN3, but Excluding SNRPN and SNORD116

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Prader‐Willi syndrome (PWS) is a neurodevelopmental disorder typically caused by large deletions or imprinting defects on chromosome 15q11.2, encompassing multiple genes. While the contribution of individual genes to the PWS phenotype remains unclear, previous studies suggested that isolated deletions of MAGEL2, NDN, and MKRN3, excluding the ...
Jannis Buecking, Yu An, Weimin Bi, Katrin Hinderhofer, Susanne Theiß, Anne Slavotinek, Christian P. Schaaf   +6 more
wiley   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, EarlyView., 2023
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source