Cysteine Oxidation Promotes Dimerization/Oligomerization of Circadian Protein Period 2
Biomolecules, 2022 The molecular circadian clock is based on a transcriptional/translational feedback loop in which the stability and half-life of circadian proteins is of importance.
Fernando Martin Baidanoff +5 more
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Decoupling circadian clock protein turnover from circadian period determination [PDF]
Science, 2015 Defining necessary circadian clock elements The circadian clock in organisms as diverse as fungi and humans have a rather similar structure: Timing depends on daily cycles of transcription in circuits in which feedback loops control the timing of oscillations. A critical role has been ascribed to negative elements,
Luis F. Larrondo +4 more
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Phosphorylation Regulating the Ratio of Intracellular CRY1 Protein Determines the Circadian Period [PDF]
Frontiers in Neurology, 2016 The core circadian oscillator in mammals is composed of transcription/translation feedback loop, in which cryptochrome (CRY) proteins play critical roles as repressors of their own gene expression. Although post-translational modifications, such as phosphorylation of CRY1, are crucial for circadian rhythm, little is known about how phosphorylated CRY1 ...
Na Liu, Na Liu, Eric Erquan Zhang
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CAVIN‐3 regulates circadian period length and PER:CRY protein abundance and interactions [PDF]
EMBO reports, 2012 In mammals, transcriptional autorepression by Period (PER) and Cryptochrome (CRY) protein complexes is essential for the generation of circadian rhythms. We have identified CAVIN-3 as a new, cytoplasmic PER2-interacting protein influencing circadian clock properties.
Schneider Kim +5 more
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Intrinsic disorder is an essential characteristic of components in the conserved circadian circuit
Cell Communication and Signaling, 2020 Introduction The circadian circuit, a roughly 24 h molecular feedback loop, or clock, is conserved from bacteria to animals and allows for enhanced organismal survival by facilitating the anticipation of the day/night cycle.
Jacqueline F. Pelham +2 more
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Heme Binding to the Mammalian Circadian Clock Protein Period 2 Is Nonspecific [PDF]
Biochemistry, 2010 The mammalian circadian clock synchronizes physical and metabolic activity with the diurnal cycle through a transcriptional-posttranslational feedback loop. An additional feedback mechanism regulating clock timing has been proposed to involve oscillation in heme availability.
Michael V, Airola +3 more
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Structure-based design and classifications of small molecules regulating the circadian rhythm period
Scientific Reports, 2021 Circadian rhythm is an important mechanism that controls behavior and biochemical events based on 24 h rhythmicity. Ample evidence indicates disturbance of this mechanism is associated with different diseases such as cancer, mood disorders, and familial ...
Seref Gul +6 more
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A Small Molecule Modulates Circadian Rhythms through Phosphorylation of the Period Protein [PDF]
Angewandte Chemie International Edition, 2011 Time shift A high-throughput cell-based screen identified a benzothiazole analogue, LH846, which induces period lengthening of the circadian rhythm. Affinity chromatography coupled with mass spectrometry and genomic analysis identified protein kinase CKIδ as the biological target of LH846 (see picture).
Jae Wook, Lee +8 more
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The Mammalian Circadian Clock Protein Period Counteracts Cryptochrome in Phosphorylation Dynamics of Circadian Locomotor Output Cycles Kaput (CLOCK) [PDF]
Journal of Biological Chemistry, 2014 The circadian transcription factor CLOCK exhibits a circadian oscillation in its phosphorylation levels. Although it remains unclear whether this phosphorylation contributes to circadian rhythm generation, it has been suggested to be involved in transcriptional activity, intracellular localization, and degradative turnover of CLOCK.
Ritsuko, Matsumura +7 more
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KidA, a multi-PAS domain protein, tunes the period of the cyanobacterial circadian oscillator
Proceedings of the National Academy of Sciences, 2022 The cyanobacterial clock presents a unique opportunity to understand the biochemical basis of circadian rhythms. The core oscillator, composed of the KaiA, KaiB, and KaiC proteins, has been extensively studied, but a complete picture of its connection to the physiology of the cell is lacking.
Soo Ji Kim +4 more
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