Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance Mitochondria are major cellular energy suppliers and have to cope with changes in nutrient supply and energy demand that naturally occur throughout the day. We obtained the first, to our knowledge, comprehensive mitochondrial proteome around the clock and identified extensive oscillations in mitochondrial protein abundance that ...
A. Neufeld-Cohen +11 more
semanticscholar +4 more sources
Circadian period is compensated for repressor protein turnover rates in single cells [PDF]
Proceedings of the National Academy of SciencesMost mammalian cells have molecular circadian clocks that generate widespread rhythms in transcript and protein abundance. While circadian clocks are robust to fluctuations in the cellular environment, little is known about the mechanisms by which the circadian period compensates for fluctuating metabolic states.
Christian Gabriel +11 more
+5 more sources
Decoupling circadian clock protein turnover from circadian period determination [PDF]
Science, 2015 Defining necessary circadian clock elements The circadian clock in organisms as diverse as fungi and humans have a rather similar structure: Timing depends on daily cycles of transcription in circuits in which feedback loops control the timing of oscillations.
Luis Larrondo +4 more
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GRK2 Fine-Tunes Circadian Clock Speed and Entrainment via Transcriptional and Post-translational Control of PERIOD Proteins [PDF]
Cell Reports, 2015 The pacemaker properties of the suprachiasmatic nucleus (SCN) circadian clock are shaped by mechanisms that influence the expression and behavior of clock proteins.
Neel Mehta +8 more
doaj +2 more sources
Regulation of αENaC expression by the circadian clock protein Period 1 in mpkCCDc14 cells [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2010 The epithelial sodium channel (ENaC) mediates the fine-tuned regulation of external sodium (Na) balance. The circadian clock protein Period 1 (Per1) is an aldosterone-induced gene that regulates mRNA expression of the rate-limiting alpha subunit of ENaC (αENaC).
Michelle L. Gumz +6 more
openalex +5 more sources
Antibodies Against the Clock Proteins Period and Cryptochrome Reveal the Neuronal Organization of the Circadian Clock in the Pea Aphid [PDF]
Frontiers in Physiology, 2021 Circadian clocks prepare the organism to cyclic environmental changes in light, temperature, or food availability. Here, we characterized the master clock in the brain of a strongly photoperiodic insect, the aphid Acyrthosiphon pisum, immunohistochemically with antibodies against A.
Francesca Sara Colizzi +6 more
openalex +6 more sources
Heterogeneous expression of the core circadian clock proteins among neuronal cell types in mouse retina. [PDF]
PLoS ONE, 2012 Circadian rhythms in metabolism, physiology, and behavior originate from cell-autonomous circadian clocks located in many organs and structures throughout the body and that share a common molecular mechanism based on the clock genes and their protein ...
Xiaoqin Liu +2 more
doaj +2 more sources
Age-Related Changes in the Expression of the Circadian Clock Protein PERIOD in Drosophila Glial Cells [PDF]
Frontiers in Physiology, 2018 Circadian clocks consist of molecular negative feedback loops that coordinate physiological, neurological, and behavioral variables into “circa” 24-h rhythms.
D. M. Long, J. Giebultowicz
semanticscholar +4 more sources
Codon usage affects the structure and function of the Drosophila circadian clock protein PERIOD [PDF]
Genes & Development, 2016 Codon usage bias is a universal feature of all genomes, but its in vivo biological functions in animal systems are not clear. To investigate the in vivo role of codon usage in animals, we took advantage of the sensitivity and robustness of the Drosophila circadian system.
Jingjing Fu +7 more
openalex +5 more sources
Heme Binding to the Mammalian Circadian Clock Protein Period 2 Is Nonspecific [PDF]
Biochemistry, 2010 The mammalian circadian clock synchronizes physical and metabolic activity with the diurnal cycle through a transcriptional-posttranslational feedback loop. An additional feedback mechanism regulating clock timing has been proposed to involve oscillation in heme availability.
Michael V. Airola +3 more
openalex +4 more sources