eLife, 2019 The Drosophila circadian pacemaker consists of transcriptional feedback loops subjected to post-transcriptional and post-translational regulation. While post-translational regulatory mechanisms have been studied in detail, much less is known about ...
Lauren E Foley +5 more
doaj +1 more source
The proteomic landscape of the suprachiasmatic nucleus clock reveals large-scale coordination of key biological processes. [PDF]
PLoS Genetics, 2014 The suprachiasmatic nucleus (SCN) acts as the central clock to coordinate circadian oscillations in mammalian behavior, physiology and gene expression.
Cheng-Kang Chiang +8 more
doaj +1 more source
A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait. [PDF]
, 2016 In humans, the connection between sleep and mood has long been recognized, although direct molecular evidence is lacking. We identified two rare variants in the circadian clock gene PERIOD3 (PER3-P415A/H417R) in humans with familial advanced sleep phase ...
Fu, Ying-Hui +15 more
core +1 more source
Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock. [PDF]
PLoS ONE, 2011 Circadian clocks coordinate the timing of important biological processes. Interconnected transcriptional and post-translational feedback loops based on a set of clock genes generate and maintain these rhythms with a period of about 24 hours.
Isabelle Schmutz +5 more
doaj +1 more source
Accurate timekeeping is controlled by a cycling activator in Arabidopsis. [PDF]
, 2013 Transcriptional feedback loops are key to circadian clock function in many organisms. Current models of the Arabidopsis circadian network consist of several coupled feedback loops composed almost exclusively of transcriptional repressors.
Devisetty, Upendra K +2 more
core +1 more source
Understanding the role of chromatin remodeling in the regulation of circadian transcription in Drosophila. [PDF]
, 2015 Circadian clocks enable organisms to anticipate daily changes in the environment and coordinate temporal rhythms in physiology and behavior with the 24-h day-night cycle. The robust cycling of circadian gene expression is critical for proper timekeeping,
Chiu, Joanna C +2 more
core +1 more source
Circadian Clock Neurons in the Silkmoth Antheraea pernyi: Novel Mechanisms of Period Protein Regulation [PDF]
Neuron, 1996 We examined Period (PER) protein regulation in the brain of the silkmoth Antheraea pernyi. PER expression is restricted to the cytoplasm and axons of eight neurons, with no evidence of temporal movement into the nucleus. These neurons appear to be circadian clock cells, because PER and per mRNA are colocalized and their levels oscillate in these cells,
Sauman, Ivo, Reppert, Steven M
openaire +2 more sources
Bio-Protocol, 2017 Circadian rhythms are biological processes displaying an endogenous oscillation with a period of ~24 h. They allow organisms to anticipate and get prepared for the environmental changes caused mainly by the rotation of Earth. Circadian rhythms are driven
Qiang Chen +3 more
doaj +1 more source
Circadian clocks and breast cancer [PDF]
, 2016 Circadian clocks respond to environmental time cues to coordinate 24-hour oscillations in almost every tissue of the body. In the breast, circadian clocks regulate the rhythmic expression of numerous genes.
Blakeman, V +3 more
core +2 more sources
Mutation of Arabidopsis SPLICEOSOMAL TIMEKEEPER LOCUS1 Causes Circadian Clock Defects [PDF]
, 2012 The circadian clock plays a crucial role in coordinating plant metabolic and physiological functions with predictable environmental variables, such as dusk and dawn, while also modulating responses to biotic and abiotic challenges.
Brown, John WS +5 more
core +1 more source