Results 51 to 60 of about 85,043 (305)

Generation of Human CRY1 and CRY2 Knockout Cells Using Duplex CRISPR/Cas9 Technology

Frontiers in Physiology, 2019
Circadian clocks are endogenous oscillators essential for orchestrating daily rhythms in physiology, metabolism and behavior. While mouse models have been instrumental to elucidate the molecular mechanism of circadian rhythm generation, our knowledge ...
Teresa Börding, Teresa Börding, Ashraf N. Abdo, Ashraf N. Abdo, Ashraf N. Abdo, Bert Maier, Bert Maier, Christian Gabriel, Christian Gabriel, Achim Kramer, Achim Kramer   +10 more
doaj   +1 more source

Rheostatic Balance of Circadian Rhythm and Autophagy in Metabolism and Disease

Frontiers in Cell and Developmental Biology, 2020
Circadian rhythms are physical, behavioral and environmental cycles that respond primarily to light and dark, with a period of time of approximately 24 h.
Xiang Wang, Zhijie Xu, Yuan Cai, Shuangshuang Zeng, Bi Peng, Xinxin Ren, Yuanliang Yan, Zhicheng Gong, Zhicheng Gong   +8 more
doaj   +1 more source

Identification of Melatonin-Regulated Genes in the Ovine Pituitary Pars Tuberalis, a Target Site for Seasonal Hormone Control [PDF]

, 2008
The pars tuberalis (PT) of the pituitary gland expresses a high density of melatonin (MEL) receptors and is believed to regulate seasonal physiology by decoding changes in nocturnal melatonin secretion.
Alison Downing, Ando, Andrew S. I. Loudon, Ashburner, Bae, Barrett, Bartness, Bechtold, Benoit Malpaux, Bockers, Bockers, Bockmann, Brahimi-Horn, Camon, Carr, Chemineau, Chen, Curlewis, Daphne Mouzaki, Dardente, Dave W. Burt, David Waddington, Draghici, Dupre, Fukuhara, Gerald A. Lincoln, Ghorbel, Graham, Grossmann, Hanon, Hazlerigg, Hazlerigg, Hazlerigg, Hogenesch, Hu, Hu, Johnston, Johnston, Johnston, Julian R. E. Davis, Kel, Kijas, Klosen, Ko, Lamolet, Lee, Lincoln, Lincoln, Lincoln, Lincoln, Malpaux, Merks, Messager, Michan, Morgan, Morgan, Mutoh, Nakao, Naya, Naya, Nilaweera, Oki, Poulin, Reick, Revollo, Richard Talbot, Roepke, Rutter, Samal, Sandrine M. Dupré, Schroeder, Segawa, Stehle, Stirland, Storey, Su, Tobler, Tournier, Wagner, Westfall, Williams, Wittkowski, Yang, Yokoyama   +83 more
core   +2 more sources

Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila [PDF]

The Journal of Neuroscience, 1990
When the protein encoded by the period (per) gene, which influences circadian rhythms in Drosophila melanogaster, was labeled with an anti- per antibody in adult flies sectioned at different times of day, regular fluctuations in the intensity of immunoreactivity were observed in cells of the visual system and central brain. These fluctuations persisted
Zerr, D. M., Hall, J. C., Rosbash, M., Siwicki, Kathleen King   +3 more
openaire   +2 more sources

Light and circadian regulation of clock components aids flexible responses to environmental signals [PDF]

, 2014
The circadian clock measures time across a 24h period, increasing fitness by phasing biological processes to the most appropriate time of day. The interlocking feedback loop mechanism of the clock is conserved across species; however, the number of loops
Akman, Ozgur E, Dixon, Laura E, Hodge, Sarah K, Millar, Andrew J, Troein, Carl, van Ooijen, Gerben   +5 more
core   +2 more sources

The Jumonji C Domain-Containing Protein JMJ30 Regulates Period Length in the Arabidopsis Circadian Clock     [PDF]

Plant Physiology, 2010
Abstract Histone methylation plays an essential role in regulating chromatin structure and gene expression. Jumonji C (JmjC) domain-containing proteins are generally known as histone demethylases. Circadian clocks regulate a large number of biological processes, and recent studies suggest that chromatin remodeling has evolved as an ...
Sheen X, Lu, Stephen M, Knowles, Candace J, Webb, R Brandon, Celaya, Chuah, Cha, Jonathan P, Siu, Elaine M, Tobin   +6 more
openaire   +2 more sources

Transcriptional Feedback Loops in the Caprine Circadian Clock System

Frontiers in Veterinary Science, 2022
The circadian clock system is based on interlocked positive and negative transcriptional and translational feedback loops of core clock genes and their encoded proteins.
Dengke Gao, Dengke Gao, Hongcong Zhao, Hongcong Zhao, Hao Dong, Hao Dong, Yating Li, Yating Li, Jing Zhang, Jing Zhang, Haisen Zhang, Haisen Zhang, Yu Zhang, Yu Zhang, Haizhen Jiang, Haizhen Jiang, Xiaoyu Wang, Xiaoyu Wang, Aihua Wang, Aihua Wang, Yaping Jin, Yaping Jin, Huatao Chen, Huatao Chen   +23 more
doaj   +1 more source

A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line [PDF]

, 2019
The circadian clock regulates key cellular processes and its dysregulation is associated to several pathologies including cancer. Although the transcriptional regulation of gene expression by the clock machinery is well described, the role of the clock ...
Abreu, Mónica, Astaburuaga, Rosario, Basti, Alireza, Genov, Nikolai, Relógio, Angela   +4 more
core   +1 more source

Mutual Antagonism between Circadian Protein Period 2 and Hepatitis C Virus Replication in Hepatocytes

PLoS ONE, 2013
Hepatitis C virus (HCV) infects approximately 3% of the world population and is the leading cause of liver disease, impacting hepatocyte metabolism, depending on virus genotype. Hepatic metabolic functions show rhythmic fluctuations with 24-h periodicity (circadian), driven by molecular clockworks ticking through translational-transcriptional feedback ...
Benegiamo, G, Mazzoccoli, G, Cappello, F, Rappa, F, Scibetta, N, Oben, J, Greco, A, Williams, R, Andriulli, A, Vinciguerra, M, Pazienza, V   +10 more
openaire   +5 more sources

Circadian Mutant Overtime Reveals F-box Protein FBXL3 Regulation of Cryptochrome and Period Gene Expression [PDF]

Cell, 2007
Using a forward genetics ENU mutagenesis screen for recessive mutations that affect circadian rhythmicity in the mouse, we isolated a long period (approximately 26 hr) circadian mutant named Overtime (Ovtm). Positional cloning and genetic complementation reveal that Ovtm is encoded by the F-box protein FBXL3, a component of the SKP1-CUL1-F-box-protein (
Siepka, Sandra M., Yoo, Seung-Hee, Park, Junghea, Song, Weimin, Kumar, Vivek, Hu, Yinin, Lee, Choogon, Takahashi, Joseph S.   +7 more
openaire   +2 more sources