Results 61 to 70 of about 85,043 (305)
Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock
eLife, 2019 Circadian oscillations emerge from transcriptional and post-translational feedback loops. An important step in generating rhythmicity is the translocation of clock components into the nucleus, which is regulated in many cases by kinases.
Andrea Brenna +9 more
doaj +1 more source
Circadian rhythms and hormonal homeostasis: Pathophysiological implications [PDF]
, 2017 Over recent years, a deeper comprehension of the molecular mechanisms that control biological clocks and circadian rhythms has been achieved. In fact, many studies have contributed to unravelling the importance of the molecular clock for the regulation ...
Bruscalupi, Giovannella, Gnocchi, Davide
core +2 more sources
Journal of Circadian Rhythms, 2011 Background The Magel2 gene is most highly expressed in the suprachiasmatic nucleus of the hypothalamus, where its expression cycles in a circadian pattern comparable to that of clock-controlled genes.
Devos Julia +2 more
doaj +1 more source
p38 Mitogen-activated Protein Kinase Regulates Oscillation of Chick Pineal Circadian Clock [PDF]
, 2003 Extracellular signal-regulated kinase (ERK) and p38 are members of the mitogen-activated protein kinase (MAPK) family, and in some cases these kinases serve for closely related cellular functions within a cell. In a wide range of animal clock structures,
Fukada, Yoshitaka +4 more
core +1 more source
Neuron, 1995 The Drosophila period protein (PER) is a predominantly nuclear protein and a likely component of a circadian clock. PER is required for daily oscillations in the transcription of its own gene and thus participates in a circadian feedback loop.
Curtin, Kathryn D +2 more
openaire +2 more sources
timrit Lengthens Circadian Period in a Temperature-Dependent Manner through Suppression of PERIOD Protein Cycling and Nuclear Localization [PDF]
Molecular and Cellular Biology, 1999 A fundamental feature of circadian clocks is temperature compensation of period. The free-running period of ritsu (timrit) (a novel allele of timeless [tim]) mutants is drastically lengthened in a temperature-dependent manner. PER and TIM protein levels become lower in timrit mutants as temperature becomes higher. This mutation reduces per mRNA but not
A, Matsumoto +3 more
openaire +2 more sources
Circadian and Ultradian Rhythms of Free Glucocorticoid Hormone Are Highly Synchronized between the Blood, the Subcutaneous Tissue, and the Brain [PDF]
, 2012 Total glucocorticoid hormone levels in plasma of various species, including humans, follow a circadian rhythm that is made up from an underlying series of hormone pulses. In blood most of the glucocorticoid is bound to corticosteroid-binding globulin and
Droste, Susanne K +4 more
core +2 more sources
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Diel transcriptional response of a California Current plankton microbiome to light, low iron, and enduring viral infection. [PDF]
, 2019 Phytoplankton and associated microbial communities provide organic carbon to oceanic food webs and drive ecosystem dynamics. However, capturing those dynamics is challenging. Here, an in situ, semi-Lagrangian, robotic sampler profiled pelagic microbes at
Allen, AE +12 more
core +2 more sources
Cysteine oxidation promotes dimerization/oligomerization of circadian protein period
, 2022 Abstract: The molecular circadian clock is based on a transcriptional/translational feedback loop in which the stability and half-life of circadian proteins is of importance. Cysteine residues of proteins are subject to several redox reactions leading to S-thiolation and disulfide bond formation, altering protein stability and function.
Baidanoff, Fernando Martín +5 more
openaire +1 more source