Results 61 to 70 of about 356,744 (339)

A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines.
Laura Bindila, Tore Eid, James D. Mills, Michael S. Hildebrand, Gary P. Brennan, Susan A. Masino, Vicky Whittemore, Piero Perucca, Christopher A. Reid, Manisha Patel, Kevin K. Wang, Erwin A. van Vliet   +11 more
wiley   +1 more source

Hsp40 overexpression in pacemaker neurons delays circadian dysfunction in a Drosophila model of Huntington's disease

Disease Models & Mechanisms, 2022
Circadian disturbances are early features of neurodegenerative diseases, including Huntington's disease (HD). Emerging evidence suggests that circadian decline feeds into neurodegenerative symptoms, exacerbating them.
Pavitra Prakash, Arpit Kumar Pradhan, Vasu Sheeba   +2 more
doaj   +1 more source

Promoter methylation in a mixed feedback loop circadian clock model [PDF]

, 2021
We introduce and analyze an extension of the mixed feedback loop model of Fran\c{c}ois and Hakim. Our extension includes an additional promoter state and allows for reversible protein sequestration, which was absent from the original studies of the mixed feedback loop model.
arxiv   +1 more source

Circadian rhythmicity by autocatalysis. [PDF]

PLoS Computational Biology, 2006
The temperature compensated in vitro oscillation of cyanobacterial KaiC phosphorylation, the first example of a thermodynamically closed system showing circadian rhythmicity, only involves the three Kai proteins (KaiA, KaiB, and KaiC) and ATP.
Arun Mehra, Christian I Hong, Mi Shi, Jennifer J Loros, Jay C Dunlap, Peter Ruoff   +5 more
doaj   +1 more source

Myb‐like transcription factors have epistatic effects on circadian clock function but additive effects on plant growth

Plant Direct, 2023
The functions of closely related Myb‐like repressor and Myb‐like activator proteins within the plant circadian oscillator have been well‐studied as separate groups, but the genetic interactions between them are less clear.
Cassandra L. Hughes, Stacey L. Harmer
doaj   +1 more source

Circadian clock genes Bmal1 and Period may regulate nocturnal spawning by controlling sex hormone secretion in razor clam Sinonovacula constricta

Frontiers in Marine Science, 2022
The circadian clock is an endogenous regulation mechanism that coordinates biological processes with daily changes, which are regulated by circadian clock genes.
Yanzi Liu, Yanzi Liu, Qinyuan He, Hanhan Yao, Zhihua Lin, Zhihua Lin, Yinghui Dong, Yinghui Dong   +7 more
doaj   +1 more source

Ubiquitin carboxyl-terminal hydrolases are required for period maintenance of the circadian clock at high temperature in Arabidopsis

Scientific Reports, 2019
Protein ubiquitylation participates in a number of essential cellular processes including signal transduction and transcription, often by initiating the degradation of specific substrates through the 26S proteasome. Within the ubiquitin-proteasome system,
Ryosuke Hayama, Peizhen Yang, F. Valverde, T. Mizoguchi, Ikuyo Furutani-Hayama, R. Vierstra, G. Coupland   +6 more
semanticscholar   +1 more source

Disruption in the regulation of casein kinase 2 in circadian rhythm leads to pathological states: cancer, diabetes and neurodegenerative disorders

Frontiers in Molecular Neuroscience, 2023
IntroductionCircadian rhythm maintains the sleep–wake cycle in biological systems. Various biological activities are regulated and modulated by the circadian rhythm, disruption of which can result in onset of diseases.
Md. Zubbair Malik, Mohammed Dashti, Yasmin Fatima, Arshad Channanath, Sumi Elsa John, R. K. Brojen Singh, Fahd Al-Mulla, Thangavel Alphonse Thanaraj   +7 more
doaj   +1 more source

Robust circadian clocks from coupled protein modification and transcription-translation cycles [PDF]

P Natl Acad Sci Usa (2010) vol. 107 (52) pp. 22540-5, 2010
The cyanobacterium Synechococcus elongatus uses both a protein phosphorylation cycle and a transcription-translation cycle to generate circadian rhythms that are highly robust against biochemical noise. We use stochastic simulations to analyze how these cycles interact to generate stable rhythms in growing, dividing cells.
arxiv   +1 more source

A global search for novel transcription factors impacting the Neurospora crassa circadian clock

G3: Genes, Genomes, Genetics, 2021
In order to identify new players modulating the circadian clock in the model Neurospora crassa, we adopted a reverse genetics strategy. Thus, we focused on transcription factors knockouts and crossed them to strains containing circadian luciferase ...
Felipe Muñoz-Guzmán, Valeria Caballero, Luis F Larrondo   +2 more
doaj   +1 more source