Results 71 to 80 of about 85,043 (305)

Human casein kinase Iδ phosphorylation of human circadian clock proteins period 1 and 2

FEBS Letters, 2001
Casein kinase Iϵ (CKIϵ), a central component of the circadian clock, interacts with and phosphorylates human period protein 1 (hPER1) [Keesler, G.A. et al. (2000) NeuroReport 5, 951–955]. A mutation in CKIϵ causes a shortened circadian period in Syrian Golden hamster. We have now extended our previous studies to show that human casein kinase Iδ (hCKIδ),
Camacho, F., Cilio, M., Guo, Y., Virshup, D.M., Patel, K., Khorkova, O., Styren, S., Morse, B., Yao, Z., Keesler, G.A.   +9 more
openaire   +2 more sources

Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless. [PDF]

The EMBO Journal, 1995
The timeless mutation (tim) leads to loss of circadian behavioral rhythms in Drosophila melanogaster. The effects of tim on rhythmicity involve interactions with period (per), a second essential clock gene, as the tim mutation suppresses circadian oscillations of per transcription and blocks nuclear localization of a PER reporter protein.
J L, Price, M E, Dembinska, M W, Young, M, Rosbash   +3 more
openaire   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Temperature compensation of the Arabidopsis circadian clock

npj Biological Timing and Sleep
The circadian clock is an endogenous, self-sustaining oscillator with a period of approximately 24 h. This timekeeping system helps organisms align their physiologies and behaviors with the day-night cycle.
Akari E. Maeda, Norihito Nakamichi
doaj   +1 more source

Conservation of Arabidopsis thaliana photoperiodic flowering time genes in onion (Allium cepa L.) [PDF]

, 2010
The genetics underlying onion development is poorly understood. Here the characterisation of onion homologues of Arabidopsis photoperiodic flowering pathway genes is reported with the end goal of accelerating onion breeding programmes by understanding ...
Massiah, Andrea J., Taylor, Andrew, Thomas, Brian   +2 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

GRK2 Fine-Tunes Circadian Clock Speed and Entrainment via Transcriptional and Post-translational Control of PERIOD Proteins

Cell Reports, 2015
The pacemaker properties of the suprachiasmatic nucleus (SCN) circadian clock are shaped by mechanisms that influence the expression and behavior of clock proteins.
Neel Mehta, Arthur H. Cheng, Cheng-Kang Chiang, Lucia Mendoza-Viveros, Harrod H. Ling, Abhilasha Patel, Bo Xu, Daniel Figeys, Hai-Ying M. Cheng   +8 more
doaj   +1 more source

PER-TIM interactions with the photoreceptor cryptochrome mediate circadian temperature responses in Drosophila. [PDF]

PLoS Biology, 2007
Drosophila cryptochrome (CRY) is a key circadian photoreceptor that interacts with the period and timeless proteins (PER and TIM) in a light-dependent manner.
Rachna Kaushik, Pipat Nawathean, Ania Busza, Alejandro Murad, Patrick Emery, Michael Rosbash   +5 more
doaj   +1 more source

Circadian Rhythm Abnormalities in Parkinson's Disease from Humans to Flies and Back [PDF]

, 2018
Clinical and research studies have suggested a link between Parkinson\u2019s disease (PD) and alterations in the circadian clock. Drosophila melanogaster may represent a useful model to study the relationship between the circadian clock and PD.
Bisaglia, Marco, De Lazzari, Federica, Sandrelli, Federica, Zordan, Mauro Agostino   +3 more
core   +1 more source