Nature Communications, 2018 The circadian clock proteins KaiA, KaiB, and KaiC reconstitute a remarkable circa-24 h oscillation of KaiC phosphorylation that persists for many days in vitro.
Tetsuya Mori +5 more
semanticscholar +1 more source
Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock
Journal of the American Chemical Society, 2021 CRY1 and CRY2 proteins are highly conserved components of the circadian clock that controls daily physiological rhythms. Disruption of CRY functions are related to many diseases, including circadian sleep phase disorder.
D. Kolarski +14 more
semanticscholar +1 more source
Generation of Human CRY1 and CRY2 Knockout Cells Using Duplex CRISPR/Cas9 Technology
Frontiers in Physiology, 2019 Circadian clocks are endogenous oscillators essential for orchestrating daily rhythms in physiology, metabolism and behavior. While mouse models have been instrumental to elucidate the molecular mechanism of circadian rhythm generation, our knowledge ...
Teresa Börding +10 more
doaj +1 more source
CK1α Collaborates with DOUBLETIME to Regulate PERIOD Function in the Drosophila Circadian Clock
Journal of Neuroscience, 2018 The animal circadian timing system interprets environmental time cues and internal metabolic status to orchestrate circadian rhythms of physiology, allowing animals to perform necessary tasks in a time-of-day-dependent manner.
Vu H Lam +6 more
semanticscholar +1 more source
Circadian Clock Neurons in the Silkmoth Antheraea pernyi: Novel Mechanisms of Period Protein Regulation [PDF]
Neuron, 1996 We examined Period (PER) protein regulation in the brain of the silkmoth Antheraea pernyi. PER expression is restricted to the cytoplasm and axons of eight neurons, with no evidence of temporal movement into the nucleus. These neurons appear to be circadian clock cells, because PER and per mRNA are colocalized and their levels oscillate in these cells,
Ivo Sauman, Steven M. Reppert
openaire +3 more sources
The E3 Ligases Spsb1 and Spsb4 Regulate RevErbα Degradation and Circadian Period
Journal of Biological Rhythms, 2019 The time-dependent degradation of core circadian clock proteins is essential for the proper functioning of circadian timekeeping mechanisms that drive daily rhythms in gene expression and, ultimately, an organism’s physiology.
Tsedey Mekbib +3 more
semanticscholar +1 more source
Transcriptional Feedback Loops in the Caprine Circadian Clock System
Frontiers in Veterinary Science, 2022 The circadian clock system is based on interlocked positive and negative transcriptional and translational feedback loops of core clock genes and their encoded proteins.
Dengke Gao +23 more
doaj +1 more source
Splice variants of DOMINO control Drosophila circadian behavior and pacemaker neuron maintenance.
PLoS Genetics, 2019 Circadian clocks control daily rhythms in behavior and physiology. In Drosophila, the small ventral lateral neurons (sLNvs) expressing PIGMENT DISPERSING FACTOR (PDF) are the master pacemaker neurons generating locomotor rhythms.
Zhenxing Liu +8 more
doaj +1 more source
Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock
eLife, 2019 Circadian oscillations emerge from transcriptional and post-translational feedback loops. An important step in generating rhythmicity is the translocation of clock components into the nucleus, which is regulated in many cases by kinases.
Andrea Brenna +9 more
doaj +1 more source
A mechanism for the generation of robust circadian oscillations through ultransensitivity and differential binding affinity [PDF]
arXiv, 2021 Biochemical circadian rhythm oscillations play an important role in many signalling mechanisms. In this work, we explore some of the biophysical mechanisms responsible for sustaining robust oscillations by constructing a minimal but analytically tractable model of the circadian oscillations in the KaiABC protein system found in the cyanobacteria $S ...
arxiv