Results 81 to 90 of about 356,744 (339)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2019 Hiroki Ueda
openalex +3 more sources
Journal of Circadian Rhythms, 2011 Background The Magel2 gene is most highly expressed in the suprachiasmatic nucleus of the hypothalamus, where its expression cycles in a circadian pattern comparable to that of clock-controlled genes.
Devos Julia +2 more
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Molecular mechanisms that regulate the coupled period of the mammalian circadian clock [PDF]
Biophyjical Journal 106 (2014), 2014 In mammals, most cells in the brain and peripheral tissues generate circadian (~24hr) rhythms autonomously. These self-sustained rhythms are coordinated and entrained by a master circadian clock in the suprachiasmatic nucleus (SCN). Within the SCN, the individual rhythms of each neuron are synchronized through intercellular signaling.
arxiv +1 more source
FRQ-CK1 Interaction Underlies Temperature Compensation of the Neurospora Circadian Clock
mBio, 2021 Temperature compensation allows clocks to adapt to all seasons by having a relatively constant period length at different physiological temperatures, but the mechanism of temperature compensation is unclear.
Yue Hu +6 more
semanticscholar +1 more source
Temperature compensation via cooperative stability in protein degradation [PDF]
, 2015 Temperature compensation is a notable property of circadian oscillators that indicates the insensitivity of the oscillator system's period to temperature changes; the underlying mechanism, however, is still unclear. We investigated the influence of protein dimerization and cooperative stability in protein degradation on the temperature compensation ...
arxiv +1 more source
Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex
eLife, 2014 The mammalian circadian clock is driven by a transcriptional–translational feedback loop, which produces robust 24-hr rhythms. Proper oscillation of the clock depends on the complex formation and periodic turnover of the Period and Cryptochrome proteins,
S. Nangle +6 more
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Molecular Oncology, EarlyView.This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain +3 more
wiley +1 more source
PER-TIM interactions with the photoreceptor cryptochrome mediate circadian temperature responses in Drosophila. [PDF]
PLoS Biology, 2007 Drosophila cryptochrome (CRY) is a key circadian photoreceptor that interacts with the period and timeless proteins (PER and TIM) in a light-dependent manner.
Rachna Kaushik +5 more
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Advanced Healthcare Materials, EarlyView.This study introduces a controllable degradation system for Mg‐based biomaterials using sputtering technology, marking a significant advancement in nerve regeneration research. The Mg‐sputtered nerve conduits demonstrate enhanced biocompatibility, biofunctionality, mechanical compatibility, and precise magnesium release, resulting in improved axonal ...
Hyewon Kim +12 more
wiley +1 more source
Discrete gene replication events drive coupling between the cell cycle and circadian clocks [PDF]
, 2015 Many organisms possess both a cell cycle to control DNA replication and a circadian clock to anticipate changes between day and night. In some cases, these two rhythmic systems are known to be coupled by specific, cross-regulatory interactions. Here, we use mathematical modeling to show that, additionally, the cell cycle generically influences ...
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