Results 91 to 100 of about 42,983 (297)
, 2016 Recurrent fever is common in children and specific infections account for the fever in most cases. PFAPA is not an uncommon cause of periodic fever during childhood. On the other hand, in patients with vesicoureteral reflux (VUR), urinary tract infection
Seyedzadeh, Abolhassan +2 more
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Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis
Advanced Science, EarlyView.This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun +15 more
wiley +1 more source
Defective apoptosis of peripheral-blood lymphocytes in hyper-IgD and periodic fever syndrome.
, 2007 Hereditary periodic fever syndromes are characterized by incapacitating attacks of fever and generalized inflammation. While the mutated genes for the major syndromes in this group are known, the pathogenesis remains unclear. The aim of this study was to
Heerde, W.L. van +5 more
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Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
, 2001 Item does not contain fulltextBACKGROUND: The hyperimmunoglobulinaemia D and periodic fever syndrome is a hereditary periodic fever, caused by deficiency of the enzyme mevalonate kinase.
Willemsen, MAAP +14 more
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Periodic fever syndromes: a patient diagnosed with recurrent Kawasaki disease
, 2020 Kawasaki disease, known as mucocutaneous lymph node syndrome, is a multi-system disease of unknown aetiology that occurs in young children under 5 years of age. the recurrence rate of Kawasaki disease is as rare as 1-3%. Especially in cases with coronary
Dogan, Eser +4 more
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Mutations in NALP12 cause hereditary periodic fever syndromes [PDF]
, 2008 NALP proteins, also known as NLRPs, belong to the CATERPILLER protein family involved, like Toll-like receptors, in the recognition of microbial molecules and the subsequent activation of inflammatory and immune responses.
유제욱
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Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
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Treatment with anakinra in the hyperimmunoglobulinemia D/periodic fever syndrome
, 2006 Hyperimmunoglobulinemia D/periodic fever syndrome is caused by recessively inherited mutations in the mevalonate kinase gene and is characterized by persistently high polyclonal serum IgD titre and recurrent febrile attacks.
Rigante D.
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