Results 51 to 60 of about 231,424 (276)

Nonchaotic Nonlinear Motion Visualized in Complex Nanostructures by Stereographic 4D Electron Microscopy [PDF]

, 2010
Direct electron imaging with sufficient time resolution is a powerful tool for visualizing the three-dimensional (3D) mechanical motion and resolving the four-dimensional (4D) trajectories of many different components of a nanomachine, e.g., a NEMS ...
Baskin, J. Spencer, Kwon, Oh-Hoon, Park, Hyun Soon, Zewail, Ahmed H.   +3 more
core  

Resistance of Primary Photosynthesis to Photoinhibition in Antarctic Lichen Xanthoria elegans: Photoprotective Mechanisms Activated during a Short Period of High Light Stress

Plants, 2023
The Antarctic lichen, Xanthoria elegans, in its hydrated state has several physiological mechanisms to cope with high light effects on the photosynthetic processes of its photobionts. We aim to investigate the changes in primary photochemical processes of photosystem II in response to a short-term photoinhibitory treatment.
Miloš Barták, Josef Hájek, Mehmet Gökhan Halıcı, Michaela Bednaříková, Angelica Casanova-Katny, Peter Váczi, Anton Puhovkin, Kumud Bandhu Mishra, Davide Giordano   +8 more
openaire   +5 more sources

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Experimental and constitutive model study on the mechanical properties of a structural plane of a rock mass under dynamic disturbance

Scientific Reports, 2022
An accurate description of the mechanical properties and deformation characteristics of a structural plane of a rock mass with a large chamber or slope under the ultimate stress with periodic stress disturbances is of great significance to ensure the ...
Yongjiang Yu, Yuntao Yang, Jingjing Liu, Pengbo Wang, Shipeng Zhang, Zhenmeng Wang, Shangqing Zhao   +6 more
doaj   +1 more source

Conformational changes in twitchin kinase in vivo revealed by FRET imaging of freely moving C. elegans

eLife, 2021
The force-induced unfolding and refolding of proteins is speculated to be a key mechanism in the sensing and transduction of mechanical signals in the living cell. Yet, little evidence has been gathered for its existence in vivo.
Daniel Porto, Yohei Matsunaga, Barbara Franke, Rhys M Williams, Hiroshi Qadota, Olga Mayans, Guy M Benian, Hang Lu   +7 more
doaj   +1 more source

Analytical and numerical analyses of the micromechanics of soft fibrous connective tissues

, 2012
State of the art research and treatment of biological tissues require accurate and efficient methods for describing their mechanical properties. Indeed, micromechanics motivated approaches provide a systematic method for elevating relevant data from the ...
A Menzel, AD Freed, AN Gent, D Ambrosi, D Balzani, DE Kiousis, G deBotton, G deBotton, G deBotton, G deBotton, G deBotton, G Shmuel, GA Holzapfel, GA Holzapfel, GA Holzapfel, GA Holzapfel, GA Holzapfel, GA Holzapfel, Gal deBotton, H Chen, I Hariton, I Hariton, J Humphrey, J Stålhand, JD Humphrey, JD Humphrey, JD Humphrey, JD Humphrey, JF Eberth, L Figueiredo Borges de, LA Taber, M Agoras, M Brun, N Gundiah, N Triantafyllidis, NC Avery, O Lopez-Pamies, P Mortier, P Ponte Castañeda, R Hill, RM Nerem, RW Ogden, S Rudykh, Tal Oren, V Alastrué, Y Lanir, YC Fung   +46 more
core   +1 more source

Strip yield modelling of fatigue crack under variable amplitude loading [PDF]

, 2011
The results from 'strip yield' approach of the FASTRAN type models of plasticity induced crack closure effects of fatigue cracks subjected to variable amplitude loadings are presented. The strip yield results are compared with authors' finite element (FE)
Sinclair, Ian, Singh, Konjengbam Darunkumar, Xu, Yigeng   +2 more
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source